DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and Sox8

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_035577.1	Gene:	Sox8 / 20681	MGIID:	98370	Length:	464	Species:	Mus musculus

Alignment Length:	408	Identity:	117/408 - (28%)
Similarity:	158/408 - (38%)	Gaps:	110/408 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TSSGSSNHSHSSSLSPQLPGINLGLGMVGGLGMGMSVGVGSGSGNTTPPPMPPADLAVPPA---- 79
            |:|..|:...|.|.:|..|..:.|||..|          |.|.|:|.    ..||...|..
Mouse    18 TASSMSHVEDSDSDAPPSPAGSEGLGRAG----------GGGRGDTA----EAADERFPACIRDA 68

  Fly    80 ------------APTPVAPKMHQHTHHHGNSHHNAPTSHSNSNTGSHHNSHDHIKRPMNAFMVWS 132
                        .|.||                       ....|....:..|:||||||||||:
Mouse    69 VSQVLKGYDWSLVPMPV-----------------------RGGGGGTLKAKPHVKRPMNAFMVWA 110

  Fly   133 RGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKP- 196
            :..|||:|...|.:||:|:||.||..|:||:|.:||||::||:|||..|.|:||||||:|||:.
Mouse   111 QAARRKLADQYPHLHNAELSKTLGKLWRLLSESEKRPFVEEAERLRVQHKKDHPDYKYQPRRRKS 175

  Fly   197 -KTLNKSPVPGGGGGGGGGGANGGVNAGGAGNSGPSGPGSVGSPKDMQPQLSPLGQSLPHLHGHP 260
             ||             |...::.|...|    ..|.||        |....:.||::  |.|...
Mouse   176 VKT-------------GRSDSDSGTELG----HHPGGP--------MYKADAVLGEA--HHHSDH 213

  Fly   261 HQSPYQSH-----PHHPHPHPHHVQLAAATLSAKYGFGSPLELSLPRLPNAFPGLAHYPLDPTLA 320
            |..  |:|     |..|....|         .|..|....|.|...||.::  |..:........
Mouse   214 HTG--QTHGPPTPPTTPKTDLH---------QASNGSKQELRLEGRRLVDS--GRQNIDFSNVDI 265

  Fly   321 LDLQAR-LQAMYAGSIYHPWRYLPLISPETPPSPPSSSGTGISSYGCVKSEKSSPNAVVAS---- 380
            .:|.:. :..|....::...:||||......|:.||.: |...|||......|....:.||
Mouse   266 SELSSEVISNMDTFDVHEFDQYLPLNGHSALPTEPSQA-TASGSYGGASYSHSGATGIGASPVWA 329

  Fly   381 -AASPPNIIXPT---PLR 394
             ..:|.... ||   |||
Mouse   330 HKGAPSASASPTEAGPLR 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	43/70 (61%)
Sox8	NP_035577.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		15/50 (30%)
		Sox_N	18..86	CDD:315171	21/104 (20%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P57073	55..97		7/64 (11%)
		SOX-TCF_HMG-box	98..168	CDD:238684	42/69 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	154..244		35/127 (28%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P57073	221..299		17/88 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	292..315		7/23 (30%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P57073	347..464		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..374
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..464
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838589
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.700