Protein Alignment Sox21a and Sox18

DIOPT Version :9

• Sequence 1: NP_001261827.1
• Gene: Sox21a / 39567
• FlyBaseID: FBgn0036411
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_033262.2
• Gene: Sox18 / 20672
• MGIID: 103559
• Length: 377
• Species: Mus musculus
• Alignment Length: 350
• Identity: 97/350 - (27%)
• Similarity: 145/350 - (41%)
• Gaps: 94/350 - (26%)

  Fly    56 GVGS-----GSGNTTPPPMPPADLAVPPAAPTPVAPKMHQHTHHHGNSHHNAPTSHSNSNTGSHH 115
            |:|:     |...|...|..||..:..|.:| |.:|:..::                ....|...
Mouse    25 GIGAAAEARGLPVTNVSPTSPASPSSLPRSP-PRSPESGRY----------------GFGRGERQ 72

  Fly   116 NSHD-HIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRA 179
            .:.: .|:|||||||||::.:|:::||.||.:||:.:||.||..||.|...:||||::||:|||.
Mouse    73 TADELRIRRPMNAFMVWAKDERKRLAQQNPDLHNAVLSKMLGKAWKELNTAEKRPFVEEAERLRV 137

  Fly   180 LHMKEHPDYKYRPRRK---------------PKTLNKSPVPGGGGGGGGGGAN-GGVNAGGAGNS 228
            .|:::||:||||||||               |..:..|..|.......|...: ..:...||...
Mouse   138 QHLRDHPNYKYRPRRKKQARKVRRLEPGLLLPGLVQPSAPPEAFAAASGSARSFRELPTLGAEFD 202

  Fly   229 GPSGPGSVGSPKDMQPQLSPLGQSLPHLHGHPHQSPYQSHPHHPHP-------HPHHVQLAAATL 286
            |      :|.|   .|:.|||...      .|.::.:...|..|..       .|:..:||.
Mouse   203 G------LGLP---TPERSPLDGL------EPGEASFFPPPLAPEDCALRAFRAPYAPELAR--- 249

  Fly   287 SAKYGFGSPLELSLPRLPNAFPGLAHYPLDPTLALDLQARLQAMYAGSIYHPWRYLPLISPETPP 351
            ...:.:|:||..:|...|.|.|                  |..:|.|::..|..:...:||  ||
Mouse   250 DPSFCYGAPLAEALRTAPPAAP------------------LAGLYYGTLGTPGPFPNPLSP--PP 294

  Fly   352 SPPSSSGTGISSYGCVKSEKSSPNA 376
            ..||..||          |:..|.|
Mouse   295 ESPSLEGT----------EQLEPTA 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	38/70 (54%)
Sox18	NP_033262.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		12/67 (18%)
		SOX-TCF_HMG-box	78..149	CDD:238684	38/70 (54%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:26939885	81..94		9/12 (75%)
		Interaction with DNA. /evidence=ECO:0000269|PubMed:26939885	105..117		6/11 (55%)
		Important for transcriptional activation. /evidence=ECO:0000269|PubMed:10742113, ECO:0000269|PubMed:7651823	160..225		14/79 (18%)
		Sox_C_TAD	187..375	CDD:288887	36/170 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838565
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870