Protein Alignment Sox21a and Sox17

DIOPT Version :9

• Sequence 1: NP_001261827.1
• Gene: Sox21a / 39567
• FlyBaseID: FBgn0036411
• Length: 407
• Species: Drosophila melanogaster
• Sequence 2: NP_001276393.1
• Gene: Sox17 / 20671
• MGIID: 107543
• Length: 419
• Species: Mus musculus
• Alignment Length: 416
• Identity: 117/416 - (28%)
• Similarity: 165/416 - (39%)
• Gaps: 95/416 - (22%)

  Fly    21 SGSSNHSHSSSLSPQLPGINLGLGMVGGLGMGMSVGVGSGSGNTTPPPMPPADLAVPPAAPTPVA 85
            :|.::...|...|.| |.:..|||                       |.|.|: ::.|.....|.
Mouse     6 AGYASDDQSQPRSAQ-PAVMAGLG-----------------------PCPWAE-SLSPLGDVKVK 45

  Fly    86 PKMHQHTHHHGNSHHNAPTSHSNSNTGSHHNSHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSE 150
            .::             ..:|.:.:.|.....:...|:|||||||||::.:|:::||.||.:||:|
Mouse    46 GEV-------------VASSGAPAGTSGRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAE 97

  Fly   151 ISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLNKSPVPGG-------G 208
            :||.||..||.||..:||||::||:|||..||::||:|||||||:.:......|.||       .
Mouse    98 LSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALVEP 162

  Fly   209 GGGGGGGANGGVNAGGAGNSGPSGPGSVGSPKDMQPQLSP-----LGQSLPHLHGHPHQSP---- 264
            ..|..|...|.|...|.|...|. ||....|..|.|.:.|     .|...|.|.|:|..:|
Mouse   163 QAGALGPEGGRVAMDGLGLPFPE-PGYPAGPPLMSPHMGPHYRDCQGLGAPALDGYPLPTPDTSP 226

  Fly   265 ----YQSHPHHPHPHPHHVQLAAATLS----AKYGF-----GSPLELSLPRLPNAFPGLAHYPLD 316
                .|.......|.|.... ||.|.:    :.|..     ..|:.:.......|.||:    |.
Mouse   227 LDGVEQDPAFFAAPLPGDCP-AAGTYTYAPVSDYAVSVEPPAGPMRVGPDPSGPAMPGI----LA 286

  Fly   317 PTLALDLQARLQ---AMYAGSIYHPWRYLPLISPETPPSPPSSSGTGISSYGCVKSEKSSPNAVV 378
            |..||.|.....   |..||..:|.....|| .|:.||.||               ::..|....
Mouse   287 PPSALHLYYGAMGSPAASAGRGFHAQPQQPL-QPQAPPPPP---------------QQQHPAHGP 335

  Fly   379 ASAASPPNIIXPTPLRFGAGTSSSAE 404
            ...:.||..:   |.|.|..::...|
Mouse   336 GQPSPPPEAL---PCRDGTESNQPTE 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	41/70 (59%)
Sox17	NP_001276393.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27		5/21 (24%)
		SOX-TCF_HMG-box	67..138	CDD:238684	41/70 (59%)
		Sox17_18_mid	203..253	CDD:403331	12/50 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..356		16/71 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838603
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.870