DRSC/TRiP Functional Genomics Resources

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Protein Alignment Sox21a and Sox12

DIOPT Version :9

Sequence 1:NP_001261827.1 Gene:Sox21a / 39567 FlyBaseID:FBgn0036411 Length:407 Species:Drosophila melanogaster
Sequence 2:NP_035568.1 Gene:Sox12 / 20667 MGIID:98360 Length:314 Species:Mus musculus


Alignment Length:233 Identity:82/233 - (35%)
Similarity:99/233 - (42%) Gaps:85/233 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 PPAAPTPVAPKMHQHTHHHGNSHHNAPTSHSNSNTGSHHNSHDHIKRPMNAFMVWSRGQRRKMAQ 141
            ||..|.|.|....:                    .|.......|||||||||||||:.:|||:..
Mouse    16 PPPGPGPAAEGARE--------------------PGWCKTPSGHIKRPMNAFMVWSQHERRKIMD 60

  Fly   142 DNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRK----PKTLNKS 202
            ..|.|||:|||||||..|:||.:.:|.||:.||:|||..||.::||||||||:|    |......
Mouse    61 QWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPR 125

  Fly   203 PVPGGGGGG------------GGGGANGGVNAGGAG----------------------------- 226
            | |||||||            ||..|:||...|||.                             
Mouse   126 P-PGGGGGGSRLKPGPQLPGRGGRRASGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRM 189

  Fly   227 -------------NSGPSGPG---SVGSP---KDMQPQ 245
                         ..||||.|   |..||   :|.:|:
Mouse   190 VPAGRAARGPAERAQGPSGEGAAASAASPTLSEDEEPE 227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sox21aNP_001261827.1 SOX-TCF_HMG-box 120..191 CDD:238684 44/70 (63%)
Sox12NP_035568.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 6/43 (14%)
SOX-TCF_HMG-box 39..110 CDD:238684 44/70 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..287 37/128 (29%)
Required for transcriptional activation activity and synergistic coactivation of transcriptional activity with POU3F2. /evidence=ECO:0000269|PubMed:18403418 282..314
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167838597
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0527
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S1275
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000028
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR10270
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R685
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.820

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