DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and Sox10

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_035567.1	Gene:	Sox10 / 20665	MGIID:	98358	Length:	466	Species:	Mus musculus

Alignment Length:	374	Identity:	107/374 - (28%)
Similarity:	137/374 - (36%)	Gaps:	151/374 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 SHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALH 181
            |..|:||||||||||::..|||:|...|.:||:|:||.||..|:||.|..|||||:||:|||..|
Mouse   100 SKPHVKRPMNAFMVWAQAARRKLADQYPHLHNAELSKTLGKLWRLLNESDKRPFIEEAERLRMQH 164

  Fly   182 MKEHPDYKYRPRRKPK---TLNKSPVPGGGGGGGGGGA-NGGVNAGGAGNSGP--SGPGSVGSPK 240
            .|:||||||:|||:..   ...::..|||....||..| .....:....:..|  ..|.|.|:|:
Mouse   165 KKDHPDYKYQPRRRKNGKAAQGEAECPGGEAEQGGAAAIQAHYKSAHLDHRHPEEGSPMSDGNPE 229

  Fly   241 DMQPQLSPLGQSLPHLHGHP-----HQSPYQS----------------HPH------------H- 271
                  .|.|||    ||.|     .::..||                .||            |
Mouse   230 ------HPSGQS----HGPPTPPTTPKTELQSGKADPKRDGRSLGEGGKPHIDFGNVDIGEISHE 284

  Fly   272 ------------------PHPHPHHVQLAAATLSAKYGFGSPL---------------------- 296
                              |:.||.||...:|   |.||.||.|
Mouse   285 VMSNMETFDVTELDQYLPPNGHPGHVGSYSA---AGYGLGSALAVASGHSAWISKPPGVALPTVS 346

  Fly   297 -----------------------------------ELSLPRLPNAFPGLA--------HYPLDPT 318
                                               .||||...:|||.::        |.|..|.
Mouse   347 PPGVDAKAQVKTETTGPQGPPHYTDQPSTSQIAYTSLSLPHYGSAFPSISRPQFDYSDHQPSGPY 411

  Fly   319 LALDLQARLQAMYAGSIYHPWRYL-----PL---ISPETPPSPPSSSGT 359
            ..       .|..|..:|..:.|:     ||   ||..:|..|.|.|.|
Mouse   412 YG-------HAGQASGLYSAFSYMGPSQRPLYTAISDPSPSGPQSHSPT 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	44/70 (63%)
Sox10	NP_035567.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		Sox_N	12..93	CDD:403592
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P56693	62..102		1/1 (100%)
		SOX-TCF_HMG-box	103..173	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..200		17/39 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..275		16/71 (23%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P56693	228..310		16/91 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..375		0/30 (0%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P56693	353..466		23/108 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..466		9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838595
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740