DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and SOX30

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_848511.1	Gene:	SOX30 / 11063	HGNCID:	30635	Length:	753	Species:	Homo sapiens

Alignment Length:	396	Identity:	102/396 - (25%)
Similarity:	149/396 - (37%)	Gaps:	99/396 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 NTTPP-------PMPPADLAVPPAAP-TPVAPKMHQHTHHHGNSHHN------APTSHSNSNTGS 113
            :|.||       ..||::|......| |||..||.............      .|:.....:|..
Human   265 HTVPPGARIQFQGAPPSELIRLTKVPLTPVPTKMQSLLEPSVKIETKDVPLTVLPSDAGIPDTPF 329

  Fly   114 HHNSHDHIKRPMNAFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLR 178
            ..:.:.|:||||||||||:|..|..:|:.||..:|:|||.:||.||..|:|.||:|:.|||::::
Human   330 SKDRNGHVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIK 394

  Fly   179 ALHMKEHPDYKYRPRRKPKTLNKSPVPGGGGGGGGGGANGGVNAGGAGNSGPSGPG--------- 234
            ..|.:|.|.:.|:||  |....:.|:           :...|.:|...|...:.|.
Human   395 EKHREEFPGWVYQPR--PGKRKRFPL-----------SVSNVFSGTTQNIISTNPTTVYPYRSPT 446

  Fly   235 -SVGSPKDMQPQLSPLGQSLPHLHGHPHQSPYQSHPHHPHPHPHHVQLAAATLSAKYGFGSPLEL 298
             ||..|....|...|:|::.|.:     |.|   .|....|.|..:...:.:.:|:.....|...
Human   447 YSVVIPSLQNPITHPVGETSPAI-----QLP---TPAVQSPSPVTLFQPSVSSAAQVAVQDPSLP 503

  Fly   299 SLPRL-PNAFPG------------LAHYPLDPT-LALDLQARL-------QAMYAGSIYHPWRYL 342
            ..|.| |..|.|            ..|....|| ::|:...|:       .|.:|.|...|.|..
Human   504 VYPALPPQRFTGPSQTDTHQLHSEATHTVKQPTPVSLESANRISSSASTAHARFATSTIQPPREY 568

  Fly   343 PLISPETPPSPPSSSGTGISSYGCVKSEKSSPNAVVASAASP---PNIIXPTPL-----RFGAGT 399
            ..:||                  |       |.:.....|||   |::..|.||     .||...
Human   569 SSVSP------------------C-------PRSAPIPQASPIPHPHVYQPPPLGHPATLFGTPP 608

  Fly   400 SSSAEH 405
            ..|..|
Human   609 RFSFHH 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	35/70 (50%)
SOX30	NP_848511.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..45
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	137..161
		SOX-TCF_HMG-box	336..406	CDD:238684	35/69 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..575		14/85 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..753
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0527
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740