DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and sox18

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001123409.1	Gene:	sox18 / 100170185	XenbaseID:	XB-GENE-483233	Length:	362	Species:	Xenopus tropicalis

Alignment Length:	311	Identity:	98/311 - (31%)
Similarity:	139/311 - (44%)	Gaps:	76/311 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 MPPADLAVPPAAPTPVAPKMHQHTHHHGNSHHNAPTSHSNSNTGSHHNS-------HDHIKRPMN 126
            :|||| .||..:|||.:|.              ||.|.:.|....:..|       ...|:||||
Frog    24 VPPAD-TVPETSPTPSSPP--------------APDSPTPSPQPGYGYSPCEEKPGDPRIRRPMN 73

  Fly   127 AFMVWSRGQRRKMAQDNPKMHNSEISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYR 191
            |||||::.:|:::||.||.:||:.:||.||..||.|:..:||||::||:|||..|:::||:||||
Frog    74 AFMVWAKDERKRLAQQNPDLHNAVLSKMLGQSWKNLSSAEKRPFVEEAERLRVQHLQDHPNYKYR 138

  Fly   192 PRRKP-----KTLNKSPVPGGGGGGGGGGANGG-----VNAGGAGNSGPSG-PGSVGSPKDM--- 242
            ||||.     |.::.||:....|..|...||..     ...||:|:....| |....||.|:
Frog   139 PRRKKQAKKLKRVDPSPLLRNEGYRGQAMANLSHFRDLHPLGGSGDLESYGLPTPEMSPLDVVEP 203

  Fly   243 -QPQLSPLGQSLPHLHGHPHQSPYQSHPHHPHPHPHHVQLAAATLSAKYGFGSPL-ELSLP--RL 303
             :|...|     ||:.......|::::.|                ...:|....| |:|||  ..
Frog   204 SEPAFFP-----PHMREEADPGPFRTYQH----------------GVDFGQEKTLREISLPYSSS 247

  Fly   304 PNAFPGLAHYPLDPTLALDLQARLQAMYAGSIYHPWRYLPLISPETPPSPP 354
            |:...|....|           ...|.|    |:|....|..:|....|||
Frog   248 PSHMGGFLRTP-----------TASAFY----YNPHGGSPACTPLGQLSPP 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	38/70 (54%)
sox18	NP_001123409.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		15/58 (26%)
		SOX-TCF_HMG-box	67..138	CDD:238684	38/70 (54%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	70..83		9/12 (75%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P43680	94..106		6/11 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..159		13/29 (45%)
		Important for transcriptional activation. /evidence=ECO:0000250\|UniProtKB:P43680	149..209		16/59 (27%)
		Sox17_18_mid	173..222	CDD:371880	12/53 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10270
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R685
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.040