DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sox21a and sox10

DIOPT Version :9

Sequence 1:	NP_001261827.1	Gene:	Sox21a / 39567	FlyBaseID:	FBgn0036411	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_001093691.1	Gene:	sox10 / 100101700	XenbaseID:	XB-GENE-480304	Length:	436	Species:	Xenopus tropicalis

Alignment Length:	375	Identity:	107/375 - (28%)
Similarity:	141/375 - (37%)	Gaps:	114/375 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 VGSGSGNTTPPPMPPADLAVPPAAPTPVAPKMHQHTHHHGNSHHNAPTSHSNSNTGSHHNSHD-- 119
            |||...:.||.|:||                       |.   |::|.....:......:|.|
Frog    15 VGSEDPSLTPDPLPP-----------------------HA---HSSPDDDEETKVKKEQDSEDER 53

  Fly   120 -----------------------------------HIKRPMNAFMVWSRGQRRKMAQDNPKMHNS 149
                                               |:||||||||||::..|||:|...|.:||:
Frog    54 FPVCIREAVSQVLSGYDWTLVPMPVRVNGGSKSKPHVKRPMNAFMVWAQAARRKLADQYPHLHNA 118

  Fly   150 EISKRLGAEWKLLTEGQKRPFIDEAKRLRALHMKEHPDYKYRPRRKPKTLNKSPVPGGGGGGGGG 214
            |:||.||..|:||.|..|||||:||:|||..|.|:||||||:|||:     |:..|..|.|.|..
Frog   119 ELSKTLGKLWRLLNENDKRPFIEEAERLRMQHKKDHPDYKYQPRRR-----KNGKPNPGEGDGSS 178

  Fly   215 GANGGVNAGGAGNSGPSGPGSVGSPKDMQPQLSPLGQSLPHLHGHP------HQSPYQSH-PHHP 272
            .|.||.             .|:        |.......|.|.||.|      ..|..||| |..|
Frog   179 EAEGGA-------------ASI--------QAHYKNSHLDHRHGSPMSDGNSEHSAGQSHGPPTP 222

  Fly   273 HPHPHHVQLAAATLSAKYGFGSPLELSLPRLP--NAFPG-LAHYPLDPTLALDLQARLQAMYAGS 334
            ...|.....|..:...:.|..|..|...|.:.  |...| ::|         |:.|.::......
Frog   223 PTTPKTELQAGKSDGKRDGSRSLGEGGKPHIDFGNVDIGEISH---------DVMANMETFDVNE 278

  Fly   335 IYHPWRYLPLISPETPPSPPSSSGTGISSYGCVKSEKSSPNAVVASAASP 384
            ..   :|||   |......||..|...||||...:..:.|:|...:...|
Frog   279 FD---QYLP---PNGHAGHPSHIGGYTSSYGLSGALAAGPSAWALAKQHP 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sox21a	NP_001261827.1	SOX-TCF_HMG-box	120..191	CDD:238684	44/70 (63%)
sox10	NP_001093691.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		13/65 (20%)
		Sox_N	12..79	CDD:372113	13/89 (15%)
		Dimerization (DIM). /evidence=ECO:0000250\|UniProtKB:P56693	48..88		2/39 (5%)
		SOX-TCF_HMG-box	89..159	CDD:238684	43/69 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	145..183		20/42 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	195..257		17/61 (28%)
		Transactivation domain (TAM). /evidence=ECO:0000250\|UniProtKB:P56693	209..295		23/100 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..346		1/1 (100%)
		Transactivation domain (TAC). /evidence=ECO:0000250\|UniProtKB:P56693	327..436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	413..436
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000028
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910