DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbp1 and Lsp2

DIOPT Version :9

Sequence 1:	NP_524065.1	Gene:	Fbp1 / 39566	FlyBaseID:	FBgn0000639	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001287042.1	Gene:	Lsp2 / 45326	FlyBaseID:	FBgn0002565	Length:	701	Species:	Drosophila melanogaster

Alignment Length:	1093	Identity:	191/1093 - (17%)
Similarity:	348/1093 - (31%)	Gaps:	472/1093 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AFAAGVVAAGRITTNQDRVQGID-RMSLED-LQLQKFILDIVQNIRQPLQQSELINLDV------ 65
            :|....:||..:.....:.:.:| :::.:| |..|||:..|:|:|.|.         ||
  Fly     3 SFTVIALAAVALLATLGQAKHLDSKVADKDFLMKQKFMYQILQHIYQD---------DVFTTPFG 58

  Fly    66 GLIADSQRYRGGID----KVMHNVIDLDRQRRLLDEHQVYSVGRLEHVQQLRGIYRLLARAQDFD 126
            |...:.:.:....|    :::.:..:|.:.:...|: .|:||...:|.:.:.|:.||...|::::
  Fly    59 GSYVEYKPWEHVADYVHPEMLEHFFELWQHQPFTDD-MVWSVMYDKHEEYVVGLVRLFYFAKNWE 122

  Fly   127 TLRRNVVYLRRNINPVLLVNALALAIRDREDTQALIVPAVQELLPELYLDEEVIQQVRSVLREQT 191
            |.:..|.:.|:::|..|.|.|:.:|...|:|.|.:::||..|:.|..|.|.:.::
  Fly   123 TFQHVVYWARQHVNKQLFVYAVTIASLFRDDMQGVVLPAHYEIHPWSYFDSQALE---------- 177

  Fly   192 QRPSLMDIVGMRQRAMNPVMSILMPWREIHMQM----ALRKQQNIQNVLGQKRVVVRAENQGQVE 252
                                     |.| |.:|    .:::..||.|      ||:|. |...|.
  Fly   178 -------------------------WAE-HYKMHGFHHVKQMDNIYN------VVIRT-NYSNVH 209

  Fly   253 GTSLLTDDIELQNFVQNLIQELALLEDV----------------TQLEQSQLINNDQREEQWVGR 301
            |:  |..|.:|..:          ||||                |:..:..::|.|:|.|.::
  Fly   210 GS--LNYDHDLAYY----------LEDVGFNAFYYYFNLDYPFWTKGGEEHVLNKDRRGELYL-- 260

  Fly   302 QRVQYQDNNQERDLGQDVDTGRLLRVSRRRLLEQQDEYQGQNIYGNQKDRFQRLLRRDDDNDDND 366
             .|.:|               .|.|....||.....|....|:|
  Fly   261 -YVHWQ---------------LLARWYLERLSHDLGEVPAFNMY--------------------- 288

  Fly   367 DDDDQDIRMGRVQLQRGISQGGLRIGGAHNLPTVSVNSDRLLHVSRRRLNAIQQDQQQDQLNGRQ 431
                                          :||.|..:..|                       :
  Fly   289 ------------------------------VPTESGYASNL-----------------------R 300

  Fly   432 RFMGLVRGDRLSEGRRVGQLDDVRQERQNNWQKQDYILTQGRTFGVQQERQNYADQLESVSRDDE 496
            .:.|:.:                       |.::::     .:|   ....||           |
  Fly   301 TYYGVPQ-----------------------WHRENH-----HSF---YHEHNY-----------E 323

  Fly   497 RLVHINRRRLNQDNQDIQQQQMHFPRRINSIGEGRRVMGERPIQDEDILKLIRGENRLKLMTDDE 561
            .:.|:
  Fly   324 HIEHV------------------------------------------------------------ 328

  Fly   562 ILEMLQRNRQQRLQKHQNDDDDDVNDDDVNVVHRQGLRSRRSLPNLRQQNNRLSEIVLHNLRQLV 626
              ||..:.....:.|::..|.:.:|
  Fly   329 --EMYTQRVMDWIHKNEKFDVETIN---------------------------------------- 351

  Fly   627 ARLNQESIAQGQLIEEQQQLINNPRLTQSERYALRLNQIRINSQRSRQVLAQIGQIEQRIQEVIG 691
                                                                          |:|
  Fly   352 --------------------------------------------------------------VLG 354

  Fly   692 QVLNQVNVNSLRGQVIDQRQVESLIADVLLGRLGQVGIMTIIRQVVQD-NNIEQIDRTGLGI--- 752
            .:: |.|.:|     :|::         ..|.|.:     :.|.:|.: ::....|.:..|:
  Fly   355 NII-QGNADS-----VDKK---------FYGSLDK-----LYRFIVNEGHHYGHGDESFPGLFMH 399

  Fly   753 ---RLSDPVVQYTLRRIV----RIVDEQREQILGGYRQEQLQMRGVSINDVRV-DKLRTRIEEHE 809
               .:.||:.....:.||    .:::...|     |.::.....||.|:.|.: :.|.|..|..:
  Fly   400 YDTSMRDPIFYEVYKTIVSHYWHLMETYPE-----YHKKDYAFEGVHIDAVHMPESLTTYFEHFD 459

  Fly   810 LDLSNL--VEQQVQGIQQE----------------IVGRQRRLNNKAFTIDMDITSDQDQDAIIR 856
            .|:||.  ||..|:|....                |..||:|||:|.|...:|:|||:.|||:::
  Fly   460 SDISNAVNVEPAVEGSADPLYTFGRNSHYKGSSYVIKARQQRLNHKPFEFTLDVTSDKAQDAVVK 524

  Fly   857 IFLGPAEDQQGRQGASLDERRRDFVLLDAIQVQLENGRNRIHRRSIDIPWTTSDVTPLVEIYRQV 921
            :|:||..|:.|.: ..|:...::|..|:..:|.||.|.|.|.|.|.|..:..:|.|..:|:|:::
  Fly   525 VFIGPKYDEHGHE-IPLEHNYQNFFELEHFKVHLEAGVNHIKRASGDFSFWVNDRTTYLELYQKL 588

  Fly   922 M------LQLKGQQAQQVVGIQQLVGENGRFPQHLLLPRGRPEGLPMQLLVVVSPLVELQVQDVV 980
            |      .:.|..|::...|:          |..::||||:..|...|...:|.|..:.:|....
  Fly   589 MDATNSDYKFKLDQSEAHCGV----------PNRMMLPRGKKGGQVFQFFYMVYPYHQPEVAQFT 643

  Fly   981 ---PAITIGIGSAS-LRDARPLGYPLDRPIHNEQELLQLTNVLLQDVVIIQEN 1029
               |.::.|:|..| ..||.|.|:|.:||:.::. ...:.|....||.|...:
  Fly   644 GYDPVVSCGVGHGSRYVDALPFGFPFNRPVKHDY-YFDVHNFKFVDVKIFHRD 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbp1	NP_524065.1	Hemocyanin_N	38..159	CDD:281684	32/130 (25%)
Fbp1	NP_524065.1	Hemocyanin_C	781..1025	CDD:281685	79/272 (29%)
Lsp2	NP_001287042.1	Hemocyanin_N	33..156	CDD:281684	32/132 (24%)
		Hemocyanin_M	163..420	CDD:278784	70/629 (11%)
		Hemocyanin_C	430..693	CDD:281685	80/274 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28IXN
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0012681
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11511
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840