DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and HERK2

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_174345.1	Gene:	HERK2 / 839937	AraportID:	AT1G30570	Length:	849	Species:	Arabidopsis thaliana

Alignment Length:	710	Identity:	156/710 - (21%)
Similarity:	271/710 - (38%)	Gaps:	153/710 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 GG--VGPPVFRKELKRLQHSLSGNTV-NLACPVYGKANITWT-KDKKPLNRELGVYVQKNWTLRF 449
            ||  :||....|..:..:..||...: |....|...:|||:. .|..|: ..|.||.    |.|.
plant   234 GGPKLGPSKDLKLYRTWETDLSYMVIENAGVEVKNSSNITYALADDSPV-APLLVYE----TARM 293

  Fly   450 VEATSEDSGLYNCKVCNAWGC---IQFDFSVQIN------DRTRSAPIIVVPQNQTVKVNGSLVM 505
            :..|......:|.    :|..   ..||:.|:::      |:.......:...|||...|..:..
plant   294 MSNTEVLEKRFNI----SWKFEVDPNFDYLVRLHFCELLVDKQNQRIFRIYINNQTAAGNFDIFA 354

  Fly   506 KC-----TVYSDLHPTVSWKRVVL---------KNASLDGLKS-VEIQNLNFTVTNDSVVLTLRN 555
            ..     .:|.|....||.|..||         ..||.|.|.| :||..|:   .|.::...:|
plant   355 HAGGKNKGIYQDYLDPVSSKNDVLWIQLGPDSSVGASGDALLSGLEIFKLS---KNGNLAHLIR- 415

  Fly   556 VTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAF 620
              ||         |:|...|:|.:.:..:|               :|   |.|.|:..|:.....
plant   416 --FD---------STGHSVSDSKMRIIWIS---------------VG---AGIAIIIFFVFLGIL 451

  Fly   621 ITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGT 685
            :..:.:: ||.|..:.: .....| :.:.::.......:..:.|.|::..:       ..||.|.
plant   452 VVCLCKK-RRSKSDESK-NNPPGW-RPLFLHVNNSTANAKATGGSLRLNTL-------AASTMGR 506

  Fly   686 GGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMV 750
                        :|.| :......:....|..:|.|.||:|...|.|.        .|::|:|..
plant   507 ------------KFTL-AEIRAATKNFDDGLAIGVGGFGKVYRGELED--------GTLIAIKRA 550

  Fly   751 KEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFL-KQNRPGA 814
             ..|:...:|....|:.::..: :|.::::|:|.|.:...:.::.||..:|.|:..| ..|.|
plant   551 -TPHSQQGLAEFETEIVMLSRL-RHRHLVSLIGFCDEHNEMILVYEYMANGTLRSHLFGSNLP-- 611

  Fly   815 PQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYL---ASRRCIHRDLAARNVLVSDGY 876
                          ||...|.|      :.....|||:.||   :.|..||||:...|:|:.:.:
plant   612 --------------PLSWKQRL------EACIGSARGLHYLHTGSERGIIHRDVKTTNILLDENF 656

  Fly   877 VMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWE-----IMT 936
            |.|::||||::.....::...:|..:....::.||..:.::...:|||:|:||:|:|     .:.
plant   657 VAKMSDFGLSKAGPSMDHTHVSTAVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEAVCARAVI 721

  Fly   937 YGDQPYPHILSAEELYSY--------LITGQRMEKPAKCSLNIY-VVMRQCWHFESCARPTFAEL 992
            ....|...|..||...|:        :|........:..||..| .:..:|...|...||...|:
plant   722 NPTLPKDQINLAEWALSWQKQRNLESIIDSNLRGNYSPESLEKYGEIAEKCLADEGKNRPMMGEV 786

  Fly   993 VESFDGILQ-----QASSNPNDAYLDLSMPMLETPPS----SGDEDDGSDTETFRETSPL 1043
            :.|.:.:||     ....|..::: ..|..:.|.|.|    :....|.|:||..:..|.|
plant   787 LWSLEYVLQIHEAWLRKQNGENSF-SSSQAVEEAPESFTLPACSNQDSSETEQSQTGSAL 845

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352	21/89 (24%)
		IGc2	408..469	CDD:197706	15/62 (24%)
		IG_like	492..583	CDD:214653	27/105 (26%)
		Ig	507..583	CDD:299845	23/90 (26%)
		PKc_like	700..1000	CDD:304357	74/317 (23%)
		TyrKc	712..996	CDD:197581	72/301 (24%)
HERK2	NP_174345.1	Malectin_like	35..403	CDD:372329	44/177 (25%)
HERK2	NP_174345.1	STKc_IRAK	526..791	CDD:270968	72/296 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I2197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050