DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and RKF1

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_174268.7	Gene:	RKF1 / 839853	AraportID:	AT1G29750	Length:	1021	Species:	Arabidopsis thaliana

Alignment Length:	1058	Identity:	196/1058 - (18%)
Similarity:	336/1058 - (31%)	Gaps:	381/1058 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 VEQDCQRSNPTQLEVIS---RKHTVP-----MLKPGYPRNTSIA---LGDNVSIECLLEDSALEP 271
            :|.:|..:|.|...|:.   :.|.:|     ::|..|.|...:|   :...:..|
plant    88 IECECSPTNDTDCHVVKFAFKDHNLPGTLPQIVKLPYLREIDLAYNYINGTLPRE---------- 142

  Fly   272 KITWLHKGNADNIDDLLQRLREQSQLPVDV-TRLITRMDEPQVLRLGNVLMEDGGWY----ICIA 331
               |. ..|...|..|:.||  ..::|.:. ...:|.:|.......|.:..|.|...    :.::
plant   143 ---WA-SSNLTFISLLVNRL--SGEIPKEFGNSSLTYLDLESNAFSGTIPQELGNLVHLKKLLLS 201

  Fly   332 ENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVAS--------------------PIPTASTGEDN 376
            .|::..|:.||...|.:.:|........:.|:.|                    |||:..:...|
plant   202 SNKLTGTLPASLARLQNMTDFRINDLQLSGTIPSYIQNWKQLERLEMIASGLTGPIPSVISVLSN 266

  Fly   377 -----DDDVENPA-------------------AEASGGVGPPVFRKELKRLQH-SLSGNTVNLAC 416
                 ..|:..|.                   ...||.:  |.:...||.|:. .||.|.:....
plant   267 LVNLRISDIRGPVQPFPSLKNVTGLTKIILKNCNISGQI--PTYLSHLKELETLDLSFNKLVGGI 329

  Fly   417 PVYGKA---------------------------------NITWTKDKKPLNRELGVYVQKNWTLR 448
            |.:.:|                                 |:.|   :.|.:|.....:..|..|.
plant   330 PSFAQAENLRFIILAGNMLEGDAPDELLRDGITVDLSYNNLKW---QSPESRACRPNMNLNLNLF 391

  Fly   449 FVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKV---NGSLVMKCTVY 510
            ...:|.:.|....|  ...:.|.::...:.:|   .....:.|.:.:|.::   :|::......|
plant   392 QSTSTKKSSKFLPC--IKDFKCPRYSSCLHVN---CGGSDMYVKEKKTKELYEGDGNVEGGAAKY 451

  Fly   511 SDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFTV----TNDS-VVLTLRNVTFDQEGWYTCLASS 570
            . |.|..:|.    .:::.|.:.....||..||:    :|.| :..:.|........::.||.:.
plant   452 F-LKPDANWG----FSSTGDFMDDNNFQNTRFTMFVPASNQSDLYKSARIAPVSLTYFHACLENG 511

  Fly   571 G--------------------LGRSNSSVYLR----------------VVSP-LPPLEIYALLHA 598
            .                    |||....:|::                ..:| :.||..|...|.
plant   512 NYTINLDFAEIRFTNDENYNRLGRRLFDIYIQEKLVAKDFNIMDEAKGAQTPIIKPLTAYVTNHF 576

  Fly   599 HPL------------------GFTLAAITIVA----------------------------LFLLG 617
            ..:                  |..::||:||:                            :|:||
plant   577 LTIRLSWAGKGTTRIPTRGVYGPIISAISIVSDSKPCERPKTGMSPGAYIAIGIGAPCLIIFILG 641

  Fly   618 SAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVST 682
            ..:|...|.|..|::                  ..|..||   ..||...:..|:.
plant   642 FLWICGCLPRCGRQR------------------KDPYEEE---LPSGTFTLRQIKF--------- 676

  Fly   683 TGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRV---VMAEAEGLPRSPQLAETI 744
                .||.....|:                     :|||.||.|   |:|:..           :
plant   677 ----ATDDFNPTNK---------------------IGEGGFGAVFKGVLADGR-----------V 705

  Fly   745 VAVKMVKEEHTDTDMASLVREMEVMKMIG-----KHINIINLLGCCSQGGPLWVIVEYAPHGNLK 804
            ||||.:..:       |.....|.:..||     :|.|::.|.|.|.:...|.:..||..:.:|
plant   706 VAVKQLSSK-------SRQGNREFLNEIGAISCLQHPNLVKLHGFCVERAQLLLAYEYMENNSL- 762

  Fly   805 DFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKEL-----TKFAF--QIARGMEYL---ASRR 859
                                  ...|.|.:|   |::     |:|..  .||:|:.:|   :..:
plant   763 ----------------------SSALFSPKH---KQIPMDWPTRFKICCGIAKGLAFLHEESPLK 802

  Fly   860 CIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDV 924
            .:|||:.|.|:|:......||:|||||| :.:.|....:|.....|.:||||.........::||
plant   803 FVHRDIKATNILLDKDLTPKISDFGLAR-LDEEEKTHISTKVAGTIGYMAPEYALWGYLTFKADV 866

  Fly   925 WSYGVLLWEI---------MTYGDQPYPHILSAEELYSYLITGQRME------------KPAKCS 968
            :|:|||:.||         |..||.    :...|.....:.:|..|:            |.|:..
plant   867 YSFGVLVLEIVAGITNSNFMGAGDS----VCLLEFANECVESGHLMQVVDERLRPEVDRKEAEAV 927

  Fly   969 LNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPN----------DAYLDLSMPM----- 1018
            :.:.:|   |.......||..:|:|...:|:.....|.|.          .|:.||...|
plant   928 IKVALV---CSSASPTDRPLMSEVVAMLEGLYPVPESTPGVSRNAGDIRFKAFKDLRRGMENNSK 989

  Fly  1019 ----LETPPSSGDEDDGS 1032
                :::.|||.....|:
plant   990 TQCSVKSYPSSSSTSSGA 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	4/13 (31%)
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	16/96 (17%)
		Ig	258..340	CDD:143165	15/86 (17%)
		I-set	394..479	CDD:254352	19/118 (16%)
		IGc2	408..469	CDD:197706	13/93 (14%)
		IG_like	492..583	CDD:214653	20/134 (15%)
		Ig	507..583	CDD:299845	18/116 (16%)
		PKc_like	700..1000	CDD:304357	79/338 (23%)
		TyrKc	712..996	CDD:197581	78/322 (24%)
RKF1	NP_174268.7	LRR	112..395	CDD:227223	49/303 (16%)
		leucine-rich repeat	125..147	CDD:275380	4/35 (11%)
		leucine-rich repeat	148..170	CDD:275380	5/23 (22%)
		leucine-rich repeat	171..194	CDD:275380	5/22 (23%)
		leucine-rich repeat	195..218	CDD:275380	5/22 (23%)
		leucine-rich repeat	219..242	CDD:275380	3/22 (14%)
		leucine-rich repeat	243..266	CDD:275380	3/22 (14%)
		leucine-rich repeat	267..287	CDD:275380	2/19 (11%)
		leucine-rich repeat	291..314	CDD:275380	4/24 (17%)
		leucine-rich repeat	315..337	CDD:275380	6/21 (29%)
		leucine-rich repeat	338..356	CDD:275380	0/17 (0%)
		Malectin	417..604	CDD:288557	28/194 (14%)
		STYKc	686..952	CDD:214568	78/338 (23%)
		STKc_IRAK	687..955	CDD:270968	78/319 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I2197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050