DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and ANX2

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001318669.1	Gene:	ANX2 / 832975	AraportID:	AT5G28680	Length:	858	Species:	Arabidopsis thaliana

Alignment Length:	964	Identity:	193/964 - (20%)
Similarity:	327/964 - (33%)	Gaps:	336/964 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 GDNVSIECLLEDSAL-------EPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLIT------ 306
            |.::|:.|...:.|:       ||...:|...|..:.....|.....|.:|...:|:.|
plant    27 GQDISLSCGASEPAVDQDKKKWEPDTKFLKTPNTVHAPATYQDPSLLSTVPYMTSRIFTAPATYE 91

  Fly   307 ---RMDEPQVLRLG---------NVLMEDGGWYICIAENQVGRTVAASY--------------VD 345
               :.|:..:|||.         |:|..    |..:|.|.:  |:.:::              |.
plant    92 IPVKGDKRHMLRLHFYPSTYTGLNILDS----YFSVAANDL--TLLSNFSAAITCQALTQAYLVR 150

  Fly   346 LYS--PSDTTTVRTTTTTTVASP-----------IP------TAS----TGEDNDDDVEN----- 382
            .||  ||:...:....|.:...|           ||      |||    :.:.:|....|
plant   151 EYSLAPSEKDVLSIIFTPSDKHPKAFAFINGIEVIPMPELFDTASLVGFSDQTSDTKTANLQTMF 215

  Fly   383 ---------PAAEASGGV-------GPPV--------------FRKELKRLQHSLSGNTVNLACP 417
                     |.::.|||:       .|.:              ||.:.:::..|.:...|.....
plant   216 RLNVGGQDIPGSQDSGGLTRTWYNDAPYIFSAGLGVTLQASNNFRIDYQKMPVSTAPADVYKTAR 280

  Fly   418 VYG-------KANITWTKDKKPLNRELGVYVQKNWT----LRFVEATSEDSGLYNCKVCNAWGCI 471
            ..|       |:|:||.           ..|..|:|    |.|.|.   .....|.||
plant   281 SQGPNGDINMKSNLTWM-----------FQVDTNFTYIMRLHFCEF---QLAKINQKV------- 324

  Fly   472 QFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCT------VYSDLHPTVSWKRVVLKNASLD 530
               |::.||:||        .|..|   |.:.::..|      .|.|.        .:..:|:..
plant   325 ---FNIFINNRT--------AQGDT---NPADILGWTGGKGIPTYKDY--------AIYVDANTG 367

  Fly   531 GLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYA- 594
            |             ..:.:.|.:...||.|..:|.                   |.|..|||:.
plant   368 G-------------GGEEISLQMTPSTFGQPEYYD-------------------SQLNGLEIFKI 400

  Fly   595 -----LLHAHPLGFTLAAITIV----------ALFLLGSA-------FITFMLRRLRREKLLKLR 637
                 |...:|....:.|...|          ..|::|||       |........:|::.....
plant   401 DTMKNLAGPNPKPSPMQANEDVKKDFQGDKRITAFVIGSAGGVAAVLFCALCFTMYQRKRKFSGS 465

  Fly   638 IETVHQW-----------TKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPA 691
            ......|           ||..|    .|:..:|....:|...:.|    |.::|....|    .
plant   466 DSHTSSWLPIYGNSHTSATKSTI----SGKSNNGSHLSNLAAGLCR----RFSLSEIKHG----T 518

  Fly   692 QGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTD 756
            ..|:|                  .:::|.|.||:|.....:|        .|.||:|. ...:::
plant   519 HNFDE------------------SNVIGVGGFGKVYKGVIDG--------GTKVAIKK-SNPNSE 556

  Fly   757 TDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDS 821
            ..:.....|:|::..: :|.::::|:|.|.:||.:.:|.:|...|.|::.|
plant   557 QGLNEFETEIELLSRL-RHKHLVSLIGYCDEGGEMCLIYDYMSLGTLREHL-------------- 606

  Fly   822 DGYLDDKPLISTQHLGEKELTKFAFQIARGMEYL---ASRRCIHRDLAARNVLVSDGYVMKIADF 883
              |...:|     .|..|...:.|...|||:.||   |....||||:...|:|:.:.:|.|::||
plant   607 --YNTKRP-----QLTWKRRLEIAIGAARGLHYLHTGAKYTIIHRDVKTTNILLDENWVAKVSDF 664

  Fly   884 GLARDIQDTEYYRKNTNG-------RLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQP 941
            ||::.       ..|.||       :....::.||..:.::...:|||:|:||:|:|::......
plant   665 GLSKT-------GPNMNGGHVTTVVKGSFGYLDPEYFRRQQLTEKSDVYSFGVVLFEVLCARPAL 722

  Fly   942 YPHILSAEE--LYSYLITGQR-------MEKPAKCSLNIYVVMRQCWHFESCA------RPT--- 988
            .|. ||.|:  |..:.:..:|       ::...|..:|...:.:.....|.|.      |||
plant   723 NPS-LSKEQVSLGDWAMNCKRKGTLEDIIDPNLKGKINPECLKKFADTAEKCLSDSGLDRPTMGD 786

  Fly   989 ------FA-ELVESFDGILQQASSNPNDAYLDL--SMPMLETPPSSGDEDDGSD 1033
                  || :|.|:.||...:..||...: :||  ....:....|:|:.|.|.|
plant   787 VLWNLEFALQLQETADGSRHRTPSNGGGS-VDLGGGGGGVTVNISAGESDLGDD 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	22/105 (21%)
		Ig	258..340	CDD:143165	22/106 (21%)
		I-set	394..479	CDD:254352	19/109 (17%)
		IGc2	408..469	CDD:197706	15/71 (21%)
		IG_like	492..583	CDD:214653	13/96 (14%)
		Ig	507..583	CDD:299845	10/81 (12%)
		PKc_like	700..1000	CDD:304357	78/334 (23%)
		TyrKc	712..996	CDD:197581	76/318 (24%)
ANX2	NP_001318669.1	Malectin_like	32..399	CDD:289580	81/447 (18%)
		Malectin	213..367	CDD:288557	35/196 (18%)
		STYKc	526..788	CDD:214568	72/300 (24%)
		STKc_IRAK	527..792	CDD:270968	72/303 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	98	1.000	Inparanoid score	I2197
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050