DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and TIE1

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_005415.1	Gene:	TIE1 / 7075	HGNCID:	11809	Length:	1138	Species:	Homo sapiens

Alignment Length:	970	Identity:	241/970 - (24%)
Similarity:	367/970 - (37%)	Gaps:	274/970 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 ESDLFFQPLNESRSLKL-LQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNISWLHNDTQILGGRGR 191
            :||...|.||.:..|:. |:.:|:.....||..|.:                          ||.
Human   346 KSDRIPQILNMASELEFNLETMPRINCAAAGNPFPV--------------------------RGS 384

  Fly   192 IKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGD 256
            |:|::         |:.......:..||.:   ....:.||              ||   :.|.|
Human   385 IELRK---------PDGTVLLSTKAIVEPE---KTTAEFEV--------------PR---LVLAD 420

  Fly   257 NVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLR---EQSQLPVDVTRLITRMDEPQVLRLGN 318
            :...||.:..|           |..|:     :|.:   :...:|:...||:|:.....|:....
Human   421 SGFWECRVSTS-----------GGQDS-----RRFKVNVKVPPVPLAAPRLLTKQSRQLVVSPLV 469

  Fly   319 VLMEDGGWYICIAENQVGRTVAASYVDL-YSPSDTTTVRTTTTTTVASPIPTAS-------TGED 375
            ....||               ..|.|.| |.|.|:|   ...:|.|..|....:       ||..
Human   470 SFSGDG---------------PISTVRLHYRPQDST---MDWSTIVVDPSENVTLMNLRPKTGYS 516

  Fly   376 NDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACP------------VYG--KANITW 426
            ....:..|.....|..|||..               :...||            |.|  :..::|
Human   517 VRVQLSRPGEGGEGAWGPPTL---------------MTTDCPEPLLQPWLEGWHVEGTDRLRVSW 566

  Fly   427 TKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCI--------QFDFSVQINDRT 483
            :....|     |..|...:.||..:.|.......|.....|...:        .:...||:...|
Human   567 SLPLVP-----GPLVGDGFLLRLWDGTRGQERRENVSSPQARTALLTGLTPGTHYQLDVQLYHCT 626

  Fly   484 RSAP------IIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWK--------------RVVLKNAS 528
            ...|      :::.|.......:    :.....||....::||              .|.:...:
Human   627 LLGPASPPAHVLLPPSGPPAPRH----LHAQALSDSEIQLTWKHPEALPGPISKYVVEVQVAGGA 687

  Fly   529 LDGL---------KSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVV 584
            .|.|         .|..|:.||   .:...:..:|........|...:..|.||..     |:..
Human   688 GDPLWIDVDRPEETSTIIRGLN---ASTRYLFRMRASIQGLGDWSNTVEESTLGNG-----LQAE 744

  Fly   585 SPLPPLEI------YALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQ 643
            .|:.....      ..|:.|.....:...:||:|..|                .|:.:|...:|:
Human   745 GPVQESRAAEEGLDQQLILAVVGSVSATCLTILAALL----------------TLVCIRRSCLHR 793

  Fly   644 WTKKVIIYRPG-GEEG-SGCSSGDLQM---PVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDS 703
              ::...|:.| |||. ...|||.|.:   |.::.|                     ...:|: .
Human   794 --RRTFTYQSGSGEETILQFSSGTLTLTRRPKLQPE---------------------PLSYPV-L 834

  Fly   704 NWEIPRQQLSLGSILGEGAFGRVV--MAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREM 766
            .||    .::...::|||.||:|:  |.:.:||..:       .|:||:||..::.|......|:
Human   835 EWE----DITFEDLIGEGNFGQVIRAMIKKDGLKMN-------AAIKMLKEYASENDHRDFAGEL 888

  Fly   767 EVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLI 831
            ||:..:|.|.|||||||.|...|.|::.:||||:|||.|||:::|            .|:..|..
Human   889 EVLCKLGHHPNIINLLGACKNRGYLYIAIEYAPYGNLLDFLRKSR------------VLETDPAF 941

  Fly   832 STQH-----LGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQD 891
            :.:|     |..::|.:||...|.||:||:.::.||||||||||||.:....|||||||:|   .
Human   942 AREHGTASTLSSRQLLRFASDAANGMQYLSEKQFIHRDLAARNVLVGENLASKIADFGLSR---G 1003

  Fly   892 TEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLI 956
            .|.|.|.|.||||::|||.|||....|.::|||||:|||||||::.|..||..:..| |||..|.
Human  1004 EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGGTPYCGMTCA-ELYEKLP 1067

  Fly   957 TGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSM 1016
            .|.|||:|..|...:|.:|||||......||.||::......:|:     ...||:::|:
Human  1068 QGYRMEQPRNCDDEVYELMRQCWRDRPYERPPFAQIALQLGRMLE-----ARKAYVNMSL 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	11/82 (13%)
		IGc2	157..215	CDD:197706	7/57 (12%)
		IG	247..336	CDD:214652	17/91 (19%)
		Ig	258..340	CDD:143165	13/84 (15%)
		I-set	394..479	CDD:254352	15/106 (14%)
		IGc2	408..469	CDD:197706	13/74 (18%)
		IG_like	492..583	CDD:214653	18/113 (16%)
		Ig	507..583	CDD:299845	17/98 (17%)
		PKc_like	700..1000	CDD:304357	127/306 (42%)
		TyrKc	712..996	CDD:197581	124/290 (43%)
TIE1	NP_005415.1	ig	129..210	CDD:278476
		EGF_CA	227..256	CDD:238011
		EGF_2	315..344	CDD:285248
		ig	356..441	CDD:278476	25/155 (16%)
		fn3	452..536	CDD:278470	22/101 (22%)
		fn3	548..632	CDD:278470	15/88 (17%)
		FN3	644..736	CDD:238020	13/98 (13%)
		PTKc_Tie1	836..1132	CDD:270671	130/319 (41%)
		TyrKc	839..1107	CDD:197581	124/290 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810