DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and RET

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_066124.1	Gene:	RET / 5979	HGNCID:	9967	Length:	1114	Species:	Homo sapiens

Alignment Length:	752	Identity:	227/752 - (30%)
Similarity:	323/752 - (42%)	Gaps:	181/752 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   376 NDDDVENPAAEASGGVGPPVFRKELKRLQHSLS-GNTVNLA------------------CPVYGK 421
            ||.|.:.|      |.|..:....:..|..||. .:|.:|:                  |..:..
Human   377 NDSDFQGP------GAGVLLLHFNVSVLPVSLHLPSTYSLSVSRRARRFAQIGKVCVENCQAFSG 435

  Fly   422 ANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLY---NCKVCNAWGCIQFDFSVQIND-- 481
            .|:.:.......|..         ||..|.:..:.||:.   :.|......|.:..:.|...|
Human   436 INVQYKLHSSGANCS---------TLGVVTSAEDTSGILFVNDTKALRRPKCAELHYMVVATDQQ 491

  Fly   482 --RTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDL----------HPT--VSWK----RVVLKNAS 528
              |...|.::|..:...|.......:.|.|....          .||  ..|:    :.:.:|.|
Human   492 TSRQAQAQLLVTVEGSYVAEEAGCPLSCAVSKRRLECEECGGLGSPTGRCEWRQGDGKGITRNFS 556

  Fly   529 L---------DG-LKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASS------------- 570
            .         || ...||.|::|....:                   ||..|
Human   557 TCSPSTKTCPDGHCDVVETQDINICPQD-------------------CLRGSIVGGHEPGEPRGI 602

  Fly   571 --GLGRSNSSVYLRVVSPLP--------PLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFML 625
              |.|..|.         .|        |.:|     ..||...|....|.|..|.  :||..:|
Human   603 KAGYGTCNC---------FPEEEKCFCEPEDI-----QDPLCDELCRTVIAAAVLF--SFIVSVL 651

  Fly   626 RRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDP 690
                   |....|...|::..|..|           ||.::   ..|...|...||.:.:|...|
Human   652 -------LSAFCIHCYHKFAHKPPI-----------SSAEM---TFRRPAQAFPVSYSSSGARRP 695

  Fly   691 AQGFNEYEFPLDS-------NWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVK 748
            :....|.:..:|:       .||.||:.|.||..||||.||:||.|.|..|  ..:...|.||||
Human   696 SLDSMENQVSVDAFKILEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHL--KGRAGYTTVAVK 758

  Fly   749 MVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPG 813
            |:||..:.:::..|:.|..|:|.: .|.::|.|.|.|||.|||.:|||||.:|:|:.||:::|..
Human   759 MLKENASPSELRDLLSEFNVLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKV 822

  Fly   814 APQRRSDSDGYL---DDKPLISTQHLGEKELT-----KFAFQIARGMEYLASRRCIHRDLAARNV 870
            .|       |||   ..:...|..|..|:.||     .||:||::||:|||..:.:||||||||:
Human   823 GP-------GYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNI 880

  Fly   871 LVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIM 935
            ||::|..|||:||||:||:.:.:.|.|.:.||:|:||||.|||.:..|.:||||||:|||||||:
Human   881 LVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIV 945

  Fly   936 TYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGIL 1000
            |.|..|||.| ..|.|::.|.||.|||:|..||..:|.:|.|||..|...||.||::.:..:.::
Human   946 TLGGNPYPGI-PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMM 1009

  Fly  1001 QQASSNPNDAYLDLSMPMLETPPSSGDEDDG-SDTET 1036
            .:...     ||||:   ..||..|...||| |:.||
Human  1010 VKRRD-----YLDLA---ASTPSDSLIYDDGLSEEET 1038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352	16/106 (15%)
		IGc2	408..469	CDD:197706	11/82 (13%)
		IG_like	492..583	CDD:214653	20/131 (15%)
		Ig	507..583	CDD:299845	19/116 (16%)
		PKc_like	700..1000	CDD:304357	142/314 (45%)
		TyrKc	712..996	CDD:197581	137/291 (47%)
RET	NP_066124.1	Cadherin	172..261	CDD:278457
		PTKc_RET	723..1012	CDD:173631	137/299 (46%)
		Pkinase_Tyr	724..1005	CDD:285015	137/291 (47%)
		Inhibitors binding	805..807		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810