DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and flt3

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_001921760.3	Gene:	flt3 / 566708	ZFINID:	ZDB-GENE-050114-4	Length:	956	Species:	Danio rerio

Alignment Length:	974	Identity:	248/974 - (25%)
Similarity:	386/974 - (39%)	Gaps:	313/974 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 SYHCELCVEQ--------DCQRSNPTQLEVISRKHTVPMLK-----------------PGYPR-- 248
            |.|...|:|:        .|.....|.:....|:.:||:||                 .|||:
Zfish    87 SIHLLQCIEKLGNEKYSVICGNKTVTAVRATQRRPSVPVLKAILKAGSTNLAQLVCTSEGYPKPT 151

  Fly   249 -----NTSIALGDNVSIECLLEDSALEPKITWLHK--------GNADNID-------DLLQRLRE 293
                 |:..|.....|..|..| |.|....::|.|        .||...:       ||.::.::
Zfish   152 LRWYGNSDDAAEGMTSSACKTE-STLISYYSYLSKNPNQKCCASNALGEECTEVYHYDLNEKNKQ 215

  Fly   294 QSQLPV----------------------------DVTRLITRM---DEPQVLRLGNVLMEDGGWY 327
            :||..:                            .|.:.||.:   |..:.|.:.:|.|...|.|
Zfish   216 KSQNIIYLKSGQSLLLRAARKHFKNPGIKWHFNNTVIKGITSLQFYDWTEHLFIESVNMAHSGLY 280

  Fly   328 ICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDV----ENPAAEAS 388
            :|                   .|||.|.|..:|        .....|.:..|:    ||.:..|.
Zfish   281 LC-------------------TSDTETPRNCST--------HVKVFEHDQIDILHLNENNSILAK 318

  Fly   389 GGVG----PPVFRKELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELGVYVQKNWTLRF 449
            ...|    ..||.....|. :.::.|...:.|....::|.|.|  .|..|.|.|.|..|
Zfish   319 NKTGFCFQSQVFSYPKARC-YWITPNQTQIQCDETSQSNFTST--FKLCNTEPGQYQMK------ 374

  Fly   450 VEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLH 514
            :| |.|.|.:.|..:|             |:|         :|: .|::.|.|.. .|...|.|.
Zfish   375 LE-TQEYSVMRNVSLC-------------ISD---------IPK-ITIRKNSSFT-TCETESPLP 414

  Fly   515 PTVSWKRV-VLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYT-------CLAS-S 570
            .|||||.. .|.....:..|.:......||   ||.....:.:.|.:....:       |:.: :
Zfish   415 VTVSWKTCPSLAKCDPEDWKEIAADQPEFT---DSDQFCQKKIGFSRRHLKSEDHLIKCCITNVA 476

  Fly   571 GLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLK 635
            |.|.| ..:.|:..|           |.:   :.:..:.||.||::..|.|.|:  |:::.|
Zfish   477 GTGCS-EKILLQTKS-----------HTY---YVICFLLIVILFMIIIALIIFI--RVKKPK--- 521

  Fly   636 LRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEY--- 697
                           |:.             |:.:|::           .|..|     |:|
Zfish   522 ---------------YQS-------------QIQMIQM-----------IGPND-----NDYIYI 542

  Fly   698 ---EFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDM 759
               ||..|..||.||:.|.||:.||.||||.||.|.|.|:.:.....:  |||||:||:|...:.
Zfish   543 DFREFKYDLKWEFPRENLELGNELGSGAFGMVVQATAYGISKPGVSVQ--VAVKMLKEKHQAVEK 605

  Fly   760 ASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNR------------- 811
            .:|:.|::::..||.|.||:||||.|:..||:::|.::..:|:|.::||.||
Zfish   606 EALMSELKMLTHIGHHENIVNLLGACTGSGPIYLIFQFCCNGDLLNYLKSNRECFHKYLTDAFNK 670

  Fly   812 -------------------------------PGAPQRRSDSDGYLDDKPLIST------------ 833
                                           |.:.::.:::|..|...  ||:
Zfish   671 DRFRGLYHNFQQNRNSSEYVLSDNSQCLNVTPASKEQENENDALLSSS--ISSGSPAEEMLECED 733

  Fly   834 QHLGEK-------ELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQD 891
            :|..|:       :|..|:||:|:||::|:::.|||||||||||||:.|..:|||||||||||:.
Zfish   734 EHQEEELHSLTYDDLLSFSFQVAKGMQFLSAKNCIHRDLAARNVLVTHGRQVKIADFGLARDIEH 798

  Fly   892 TEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLI 956
            ...|....|.|||:|||||||:.:..|..:||:|:||:|||||.:.|..|||.:......|..:.
Zfish   799 DSNYVVRGNVRLPVKWMAPESIFKGIYTMESDIWAYGILLWEIFSLGVTPYPGVTVNNTFYRMIE 863

  Fly   957 TGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLE 1020
            :|..:|:|...:.::|.||.:||......||.|:::|                |:::..:..||
Zfish   864 SGYHLEQPYYAAESVYKVMCRCWALNPVDRPCFSKIV----------------AFMEKELAALE 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	6/28 (21%)
		IGc2	157..215	CDD:197706	2/3 (67%)
		IG	247..336	CDD:214652	26/141 (18%)
		Ig	258..340	CDD:143165	23/127 (18%)
		I-set	394..479	CDD:254352	20/84 (24%)
		IGc2	408..469	CDD:197706	17/60 (28%)
		IG_like	492..583	CDD:214653	24/99 (24%)
		Ig	507..583	CDD:299845	20/84 (24%)
		PKc_like	700..1000	CDD:304357	128/362 (35%)
		TyrKc	712..996	CDD:197581	123/346 (36%)
flt3	XP_001921760.3	IGc2	225..283	CDD:197706	10/76 (13%)
flt3	XP_001921760.3	PKc_like	522..907	CDD:328722	138/433 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810