DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Alk

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001261027.1	Gene:	Alk / 53425	FlyBaseID:	FBgn0040505	Length:	1701	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	137/434 - (31%)
Similarity:	216/434 - (49%)	Gaps:	61/434 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   604 TLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQM 668
            ::..|::..||:..:|.|..:..|.:|:|..|.|        .|:::.:            |||
  Fly  1107 SILMISLAVLFICIAALIFMLYNRYQRKKQSKKR--------HKMLVEQ------------DLQ- 1150

  Fly   669 PVIRIEKQRTTVSTTGTGGTDP---AQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAE 730
                :.:.|..:..:.....:|   ..|.......::|..::.|..|.|.:.||:||||.|.||.
  Fly  1151 ----LTRLRNNIDDSNLNNFNPNYGCDGILNGHIDVNSLPQVARDSLQLVNALGKGAFGEVYMAL 1211

  Fly   731 AEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIV 795
            ..  .|.....|..||||.::|:.........::|..:|... .|.|:::|:|.|....|.::::
  Fly  1212 YR--HRDGDAVEMGVAVKTLREDPKREKEEDFLKEAAIMAKF-NHPNMVHLIGVCFDRQPYYIVL 1273

  Fly   796 EYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRC 860
            |....|:|:.||::|| ..|:|           |.:.|.    |:|...|..:|:|..|:.|:|.
  Fly  1274 ELLAGGDLQKFLRENR-NTPER-----------PSLLTM----KDLLFCALDVAKGCRYMESKRF 1322

  Fly   861 IHRDLAARNVLVSD---GYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQS 922
            ||||:||||.|:|.   |.|:||||||::|||..::||||.....||||||.||:..:..:.|::
  Fly  1323 IHRDIAARNCLLSSKGPGRVVKIADFGMSRDIYRSDYYRKGGKAMLPIKWMPPEAFLDGIFTSKT 1387

  Fly   923 DVWSYGVLLWEIMTYGDQPYP--HILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCA 985
            ||||:|:||||:.:.|..|||  |.....||   ::.|.|:..|.:|.::||.||..||:.....
  Fly  1388 DVWSFGILLWEVFSLGRSPYPGQHNTQVMEL---VVRGGRLGSPTECPVSIYKVMADCWNPTPED 1449

  Fly   986 RPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDED 1029
            ||||..|:|......|.||      .::..:|.:..|.:|..:|
  Fly  1450 RPTFITLLEHLTACTQDAS------IMNAPLPNILGPTASERDD 1487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653
		Ig	507..583	CDD:299845
		PKc_like	700..1000	CDD:304357	113/304 (37%)
		TyrKc	712..996	CDD:197581	111/288 (39%)
Alk	NP_001261027.1	MAM	288..450	CDD:279023
		MAM	288..447	CDD:99706
		MAM	505..691	CDD:279023
		MAM	505..689	CDD:99706
		PTKc_ALK_LTK	1186..1462	CDD:270632	112/297 (38%)
		TyrKc	1193..1460	CDD:197581	111/288 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455248
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940