DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and PDGFRB

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_002600.1	Gene:	PDGFRB / 5159	HGNCID:	8804	Length:	1106	Species:	Homo sapiens

Alignment Length:	1022	Identity:	265/1022 - (25%)
Similarity:	390/1022 - (38%)	Gaps:	327/1022 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 SYHCELCV---EQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPK 272
            ||.|:..:   |.|.......:|:|.|...:|..::      |.:..|:|:::.|::..:.: ..
Human   187 SYICKTTIGDREVDSDAYYVYRLQVSSINVSVNAVQ------TVVRQGENITLMCIVIGNEV-VN 244

  Fly   273 ITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEP----QVLRLGNVLMEDGGWYICIAEN 333
            ..|.:.            .:|..:|...||..:  :|.|    .:|.:.:..:||.|.|.|....
Human   245 FEWTYP------------RKESGRLVEPVTDFL--LDMPYHIRSILHIPSAELEDSGTYTCNVTE 295

  Fly   334 QVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRK 398
            .|.           ...|...:..|.                    ||:......|.||...| .
Human   296 SVN-----------DHQDEKAINITV--------------------VESGYVRLLGEVGTLQF-A 328

  Fly   399 ELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELG-----------------VYVQKNWT 446
            ||.|      ..|:.:....|....:.|.||    ||.||                 .||.:
Human   329 ELHR------SRTLQVVFEAYPPPTVLWFKD----NRTLGDSSAGEIALSTRNVSETRYVSE--- 380

  Fly   447 LRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYS 511
            |..|.....::|.|..:..:....:|..|.:|||     .|:.|:..:::...:|...::|....
Human   381 LTLVRVKVAEAGHYTMRAFHEDAEVQLSFQLQIN-----VPVRVLELSESHPDSGEQTVRCRGRG 440

  Fly   512 DLHPTVSWKRV-VLKNA------SLDGLKSVEIQNLNFTVT------NDSVVLTLRNVTFDQEGW 563
            ...|.:.|... .||..      :|.|..|.|...|...||      ...||.|||....|:...
Human   441 MPQPNIIWSACRDLKRCPRELPPTLLGNSSEEESQLETNVTYWEEEQEFEVVSTLRLQHVDRPLS 505

  Fly   564 YTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAIT-IVALFLLG--SAFITFML 625
            ..|...:.:|:....|   :|.|            |.|.|.:..|: |:||.:|.  |..|..||
Human   506 VRCTLRNAVGQDTQEV---IVVP------------HSLPFKVVVISAILALVVLTIISLIILIML 555

  Fly   626 RRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGG--- 687
                              |.||.                       |.|.:...:.:..:.|
Human   556 ------------------WQKKP-----------------------RYEIRWKVIESVSSDGHEY 579

  Fly   688 --TDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMV 750
              .||.|      .|.||.||:||.||.||..||.||||:||.|.|.||..|.  |...|||||:
Human   580 IYVDPMQ------LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSHSQ--ATMKVAVKML 636

  Fly   751 KEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAP 815
            |.....::..:|:.|:::|..:|.|:|::||||.|::|||:::|.||..:|:|.|:|.:|:....
Human   637 KSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYGDLVDYLHRNKHTFL 701

  Fly   816 QRRSD-----------------------------SD-GYLD------------------------ 826
            |..||                             || ||:|
Human   702 QHHSDKRRPPSAELYSNALPVGLPLPSHVSLTGESDGGYMDMSKDESVDYVPMLDMKGDVKYADI 766

  Fly   827 ---------------------------DKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRD 864
                                       :.|::|..     :|..|::|:|.|||:|||:.|:|||
Human   767 ESSNYMAPYDNYVPSAPERTCRATLINESPVLSYM-----DLVGFSYQVANGMEFLASKNCVHRD 826

  Fly   865 LAARNVLVSDGYVMKIADFGLARDI-QDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYG 928
            |||||||:.:|.::||.|||||||| :|:.|..|.:. .||:|||||||:....|.:.|||||:|
Human   827 LAARNVLICEGKLVKICDFGLARDIMRDSNYISKGST-FLPLKWMAPESIFNSLYTTLSDVWSFG 890

  Fly   929 VLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELV 993
            :|||||.|.|..|||.:...|:.|:.:..|.||.:||..|..||.:|::||..:...||.|::||
Human   891 ILLWEIFTLGGTPYPELPMNEQFYNAIKRGYRMAQPAHASDEIYEIMQKCWEEKFEIRPPFSQLV 955

  Fly   994 --------ESFDGILQQASS-------------------------------------NPNDAYLD 1013
                    |.:....||...                                     .||:...|
Human   956 LLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGFHGLRSPLDTSSVLYTAVQPNEGDND 1020

  Fly  1014 LSMPMLETPPSSGDED--DGSD---TETFRET---------SPLRYQ 1046
            ..:|:.:..|...||.  :||.   :.|..|.         |||..|
Human  1021 YIIPLPDPKPEVADEGPLEGSPSLASSTLNEVNTSSTISCDSPLEPQ 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	6/23 (26%)
		IGc2	157..215	CDD:197706	2/3 (67%)
		IG	247..336	CDD:214652	17/92 (18%)
		Ig	258..340	CDD:143165	15/85 (18%)
		I-set	394..479	CDD:254352	21/101 (21%)
		IGc2	408..469	CDD:197706	15/77 (19%)
		IG_like	492..583	CDD:214653	22/103 (21%)
		Ig	507..583	CDD:299845	21/88 (24%)
		PKc_like	700..1000	CDD:304357	143/389 (37%)
		TyrKc	712..996	CDD:197581	135/373 (36%)
PDGFRB	NP_002600.1	ig	37..114	CDD:278476
		IG	40..110	CDD:214652
		IG_like	222..310	CDD:214653	19/119 (16%)
		Ig1_PDGFR-alphabeta	228..312	CDD:143269	19/129 (15%)
		Ig4_PDGFR-alpha	314..415	CDD:143267	27/119 (23%)
		Ig	425..523	CDD:299845	22/100 (22%)
		PTKc_PDGFR_beta	562..953	CDD:133238	145/404 (36%)
		Pkinase_Tyr	600..953	CDD:285015	132/360 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1106		13/49 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810