DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Styk1

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_038964794.1	Gene:	Styk1 / 500340	RGDID:	1564211	Length:	436	Species:	Rattus norvegicus

Alignment Length:	498	Identity:	123/498 - (24%)
Similarity:	204/498 - (40%)	Gaps:	105/498 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   572 LGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKL 636
            |||.|...:|..:     ...|.::........:....:|..||:..|.|.::..|.:|.:.
  Rat    11 LGRGNCVRFLLFL-----FMAYTVVQEKQYEVIIVPALLVGSFLILLAIILWLFIRGQRSQR--- 67

  Fly   637 RIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPL 701
                          ..||       ..|...:|..|             |.:..|.|..|..|
  Rat    68 --------------QHPG-------PRGTTSVPASR-------------GRSQEAVGHGEKVF-- 96

  Fly   702 DSNWEIPRQQLSLGSILGEGAFGRVV---MAEAEGLPRSPQLAE-----------TIVAVKMVKE 752
                 :|.::.|:.|.|      |.|   :|:.: :||. ||.|           |:...||...
  Rat    97 -----VPLKETSVESFL------RAVTPSLAKLQ-VPRE-QLLEVLEQIHSGSCGTLYHAKMTTM 148

  Fly   753 EHTD---------------TDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGN 802
            ||.:               .::...:..::..:.:|||.|::.|.|||::..||::::|....|:
  Rat   149 EHPNPKSVVLKALEGSVGLQEVQDFIGRIQFYQYLGKHKNLVQLEGCCTERLPLYMMLEDVVPGD 213

  Fly   803 LKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAA 867
            |.:||...|...    ...||.|.|        |.||::.....|:...:|:|..:...|.|:||
  Rat   214 LLNFLWTCRRDV----MTMDGLLYD--------LTEKQIYHIGKQVLLALEFLQEKHLFHGDVAA 266

  Fly   868 RNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLW 932
            ||:|:......|:...|||.::..........:..:|:||:|||.|..:....:.||||:|:||:
  Rat   267 RNILIQSDLTPKLCHLGLAYEVHTHGAISSARSSTIPLKWLAPERLLLRPASIRGDVWSFGILLY 331

  Fly   933 EIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFD 997
            |::|.|..|||.: ....:..||...:.|::|:.|:..:|.:|:.||.:...:||...||...
  Rat   332 EMVTLGAPPYPEV-PPTSILQYLQRKKIMKRPSSCTHAMYNIMKYCWRWSEDSRPLPGELRLR-- 393

  Fly   998 GILQQASSNPNDAYLDLSMPMLETPPSSGDEDDGSDTETFRET 1040
              |:.||...||..: |.:|.|..|....|. .|..||:..::
  Rat   394 --LEAASRTANDKAV-LQVPELVVPDLYADV-AGISTESLSDS 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653	5/10 (50%)
		Ig	507..583	CDD:299845	5/10 (50%)
		PKc_like	700..1000	CDD:304357	87/328 (27%)
		TyrKc	712..996	CDD:197581	86/312 (28%)
Styk1	XP_038964794.1	PKc_like	130..395	CDD:419665	75/281 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810