DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Ret

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster

Alignment Length:	1080	Identity:	261/1080 - (24%)
Similarity:	412/1080 - (38%)	Gaps:	323/1080 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 NSGNYGCLDSQNRWYNISLVVGHKEPVGND---------IASFVKL------------------- 120
            |:|:...:..|||.|. ...:.|.|..|.:         |...|||
  Fly   192 NAGSSHFVLKQNRLYT-RQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDR 255

  Fly   121 -EDAPALPESDLFF-----QP---LNESRSLKLLQPLPKTVQRTA----------GGLFQLNCSP 166
             ::.|.|.||...|     ||   .:|....|::.....|::..|          .|||:.:|..
  Fly   256 NDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHA 320

  Fly   167 MDPDAKG-----------VNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGS------YHC 214
            .:.|..|           .:.:.:..:|...     :.|:...||:  :...||.|      ||.
  Fly   321 YEADHTGRPHTIVSCQLRFSRNGVFRETPYC-----VSLEARDLTI--VSRVDAMSATANVCYHI 378

  Fly   215 ELCVEQDCQRSNPTQLEVISRKHTV------------PMLKP---GYPRNTSIALGDNVSIECLL 264
            .|....:.::..|..|.:.:|:|.:            ..|.|   .|.::.|:......:...:.
  Fly   379 NLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQ 443

  Fly   265 EDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVL--------------- 314
            .||.|:  :..|.....|.::|.|      ....:..|..|..:..||||
  Fly   444 PDSFLD--LMRLRSIRFDIVEDKL------GAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWI 500

  Fly   315 --------RLGNVLMEDGGWYICIAENQV---GRTVA--------ASYVDLYSPSDTTTVRTTTT 360
                    |:.||.:..|.......|.:|   .:|.|        ..|..|.:...:...|.:.:
  Fly   501 DQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNS 565

  Fly   361 ----TTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPVYGK 421
                |...|.:|.:....|:   |.:|..|    :.|                    :|||
  Fly   566 AMFGTRYGSCVPESRYCPDH---VCDPLEE----LNP--------------------MACP---- 599

  Fly   422 ANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSA 486
                  :|..|..|.:|.:          .:.....|:|:.    :..||..|     |.:...|
  Fly   600 ------QDCTPAGRIVGPH----------SSNENKRGIYSA----SGTCICED-----NGKCSCA 639

  Fly   487 PIIVVP--------QNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFT 543
            |:...|        :|:|               :..|.:..:|....|..|
  Fly   640 PLDEEPKMKKPRKRKNET---------------EAEPLLGVRRGTPPNQPL-------------- 675

  Fly   544 VTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAI 608
              .|.::|.:.||             :|.....|.::..:..||    ::.||
  Fly   676 --QDPMLLGVLNV-------------AGFECDRSCMFFVITCPL----LFVLL------------ 709

  Fly   609 TIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRI 673
               .|.||           :.:.|:|:.|:                |::....||
  Fly   710 ---LLCLL-----------IAQRKMLQRRL----------------GKQSMTTSS---------- 734

  Fly   674 EKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVV---MAEAEGLP 735
             ||....|..|.....|.|....:|.. |:.||.||::|.|.::||||.||:|:   ..|..|||
  Fly   735 -KQALPESGGGDFALMPLQSGFRFESG-DAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLP 797

  Fly   736 RSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPH 800
                 ..|.|||||:|:.....:..:|:.|.::::.: .|.|:|.|||.|:......:|:|||.:
  Fly   798 -----GITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARY 856

  Fly   801 GNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDL 865
            |:|:.:|:.:|.........:||         .:.:..|.:..||:||.:||.||:..:.:||||
  Fly   857 GSLRSYLRLSRKIECAGVDFADG---------VEPVNVKMVLTFAWQICKGMAYLSELKLVHRDL 912

  Fly   866 AARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVL 930
            ||||||::||.:.||:||||.||:.:.:.|.|.:..|:|:||||||||.:..|.|:|||||:|||
  Fly   913 AARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVL 977

  Fly   931 LWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVES 995
            .||::|.|..|||.| :.:.|:|.|.||.||::|..||..:|.::|.||..|...||:|..|...
  Fly   978 CWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASE 1041

  Fly   996 FDGILQQASSNPNDAYLDLSMPMLETPPSSGDEDDGSDTE 1035
            |:.:|     ..|..|:||....:..|...||:.....||
  Fly  1042 FEKLL-----GNNAKYIDLETNAVSNPLYCGDDSALITTE 1076

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	20/109 (18%)
		IGc2	157..215	CDD:197706	15/74 (20%)
		IG	247..336	CDD:214652	20/114 (18%)
		Ig	258..340	CDD:143165	20/107 (19%)
		I-set	394..479	CDD:254352	12/84 (14%)
		IGc2	408..469	CDD:197706	9/60 (15%)
		IG_like	492..583	CDD:214653	13/98 (13%)
		Ig	507..583	CDD:299845	10/75 (13%)
		PKc_like	700..1000	CDD:304357	123/302 (41%)
		TyrKc	712..996	CDD:197581	117/286 (41%)
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	119/299 (40%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	117/286 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455228
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.940