DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Tie

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_523928.1	Gene:	Tie / 38559	FlyBaseID:	FBgn0014073	Length:	1233	Species:	Drosophila melanogaster

Alignment Length:	877	Identity:	217/877 - (24%)
Similarity:	329/877 - (37%)	Gaps:	264/877 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 GNADNIDDLLQRLREQSQLPVDVTRLITRM----DEPQVLRLGNVLMEDGGWYICIAENQVGRTV 339
            |.:|:|.||.|...|.:: || |.|::.::    ..|.::   .||..:       .|..||:|.
  Fly   457 GLSDSIQDLKQTESEVAK-PV-VRRVVQKVSPSSSTPLII---TVLSAE-------EETTVGQTE 509

  Fly   340 AASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEAS-----GGVGPPVFRKE 399
            |.       |:|.:|..|:||||...|..|.||.......|.:.:...:     .....|.....
  Fly   510 AL-------PTDESTTTTSTTTTTEKPSTTTSTSTTTTTPVPSTSKRTTTNAPLSTTNTPTTTTS 567

  Fly   400 LKRLQHSLSGNTVNLACPVYGKANITWTKDKK-------PLNRELGVYVQKNWTLRFVEATSEDS 457
            ......:.:.:|.....|...|||....|||:       .|.||:.:....| .:.|...||:
  Fly   568 STTPSTTTTSSTSTTVIPTTTKANSIIEKDKELIRALGPALTREINIDDANN-LIVFCNNTSD-- 629

  Fly   458 GLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRV 522
                   |.                       |.|:.||              ...|.|.|..:
  Fly   630 -------CG-----------------------VTPRTQT--------------QPSHTTDSSPK- 649

  Fly   523 VLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVV--- 584
            :|:...|..::|........|.|..|...|               |...:...::.||:.:|
  Fly   650 ILRTTVLTSIRSTVHPRPTSTSTTTSTTTT---------------APPAVTAPSNEVYIGIVESS 699

  Fly   585 SPLPPLEIYALLHAH--PLGFTLAAITIVALFLLG------SAFITFMLRRL---RREKLLKL-- 636
            |...|.:|.:.:.|:  .|...:..:.:|.|.|:.      :|.|.:::|..   ||.|..::
  Fly   700 SSASPADISSTVIANERDLNMEMRRMNLVTLVLVAVGVIPLAAIILYLVRNFVIRRRAKQSEVFD 764

  Fly   637 -------RIETVHQWTKKVIIYRPGGEEGSGCSSGDLQ----------------------MPVIR 672
                   .|..|.:...|   |:...:|    ...|.|                      ||:.:
  Fly   765 VCITDQQPISPVKKVDSK---YQVDDDE----DEVDHQHHQHMQHHQNHQNHQNHQHHQAMPMSQ 822

  Fly   673 IEKQRTTVSTTGTGG--TDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLP 735
            ..::....:..|...  |..|..|:::|          |..:.|.|:||||.||:|..|||:.|
  Fly   823 ASQRDANHNRYGNNDDKTSLASEFHDFE----------RSNIRLKSLLGEGNFGQVWKAEADDL- 876

  Fly   736 RSPQLAET-IVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAP 799
             |.....| |||||.::   ..:...||..|..:|:.:|.|.|::.|||.|.:..|..:|:|||.
  Fly   877 -SGHFGATRIVAVKTIR---ACSAQVSLKDEANIMRKLGSHQNVVTLLGACVESEPHMLIMEYAM 937

  Fly   800 HGNLKDFLKQNR----------PGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEY 854
            .|.|...|:..|          ||..                |...|..:.|..||..||.||||
  Fly   938 RGRLLSLLRAARSATNILPASVPGGR----------------SLAPLSPRTLAGFALDIACGMEY 986

  Fly   855 LASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRK---------------------- 897
            :|.||.:||||||||||:....:.||.|||::.|: |.|..||
  Fly   987 IAGRRIVHRDLAARNVLLDHNGMCKICDFGMSIDL-DAERMRKEQEKNAANDLMRHNAHKFKFDF 1050

  Fly   898 -------------------------------------NTNGR---LPIKWMAPESLQEKKYDSQS 922
                                                 :|.|:   |||:||||||||...:.:::
  Fly  1051 GSRYILQHWQHTFGQGQGQGHCSKDQPHGEKKSHHGHDTIGKRHALPIRWMAPESLQYHMFTTET 1115

  Fly   923 DVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARP 987
            |:|::|::||||.|.|..||.. |:..|:...:..|.|.:.|.:.....|.:|.:|||.|...||
  Fly  1116 DIWAFGIVLWEIATLGSTPYSQ-LTGREVIRRVPQGLRPDLPKESRHEFYNLMSRCWHKEPHMRP 1179

  Fly   988 TFA----ELVESFDGILQQASSNPNDAYLDLS 1015
            :||    |:..|....:...|:..:  |:|:|
  Fly  1180 SFAQSRLEITRSLHKWVDDDSAASD--YMDVS 1209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	15/60 (25%)
		Ig	258..340	CDD:143165	18/64 (28%)
		I-set	394..479	CDD:254352	17/91 (19%)
		IGc2	408..469	CDD:197706	16/67 (24%)
		IG_like	492..583	CDD:214653	16/90 (18%)
		Ig	507..583	CDD:299845	13/75 (17%)
		PKc_like	700..1000	CDD:304357	118/376 (31%)
		TyrKc	712..996	CDD:197581	116/360 (32%)
Tie	NP_523928.1	TyrKc	854..1183	CDD:197581	114/351 (32%)
Tie	NP_523928.1	PTKc	860..1187	CDD:270623	113/349 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45455232
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840