DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment btl and KIT

DIOPT Version :10

Sequence 1:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_001372213.1 Gene:KIT / 3815 HGNCID:6342 Length:977 Species:Homo sapiens


Alignment Length:1113 Identity:293/1113 - (26%)
Similarity:438/1113 - (39%) Gaps:338/1113 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 ENSPRQRHL-LSDM------DITLQCVRP-MAKWFYE---DKFQLRATLLRLERAQSGNSGNYGC 90
            |.||...|. .||:      :|.|.|..| ..||.:|   :..:.:......|:|::.|:|.|.|
Human    33 EPSPPSIHPGKSDLIVRVGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTC 97

  Fly    91 LDSQNRWYNISLVVGHKEPVGNDIASFVK------LEDAPALPESD---LFFQPLNE----SRSL 142
            .              :|..:.|.|..||:      |.|.....:.|   |...||.:    :.||
Human    98 T--------------NKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSL 148

  Fly   143 KLLQ--PLPKTVQRTAGGLFQLNCSPMDPDAK-GVNISWLHNDTQILGGRGRIKLKRWSLTVGQL 204
            |..|  ||||.::             ..||.| |:.|.               .:||        
Human   149 KGCQGKPLPKDLR-------------FIPDPKAGIMIK---------------SVKR-------- 177

  Fly   205 QPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIAL---------GDNVSI 260
                  :|| .||:.....:...:   |:|.|. :..::|.:.....:::         |:..::
Human   178 ------AYH-RLCLHCSVDQEGKS---VLSEKF-ILKVRPAFKAVPVVSVSKASYLLREGEEFTV 231

  Fly   261 ECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITR----------MDEPQVLR 315
            .|.::|.:.....||               .||.||    .|:|..:          .:....|.
Human   232 TCTIKDVSSSVYSTW---------------KRENSQ----QTKLQEKYNSWHHGDFNYERQATLT 277

  Fly   316 LGNVLMEDGGWYICIAENQVG--------RTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTAST 372
            :.:..:.|.|.::|.|.|..|        ..|...::::: |...|||             ..:.
Human   278 ISSARVNDSGVFMCYANNTFGSANVTTTLEVVDKGFINIF-PMINTTV-------------FVND 328

  Fly   373 GEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPVYGKANIT--WTKDKKPLNR 435
            ||:.|..||..|           |.|.    :|...         :|.....|  |....|..|.
Human   329 GENVDLIVEYEA-----------FPKP----EHQQW---------IYMNRTFTDKWEDYPKSENE 369

  Fly   436 ELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVK-- 498
            ....||.:   |........:.|.|...|.|:.......|:|.:|.:         |:..|..  
Human   370 SNIRYVSE---LHLTRLKGTEGGTYTFLVSNSDVNAAIAFNVYVNTK---------PEILTYDRL 422

  Fly   499 VNGSLVMKCTVYSDLHPTVSW-------KRVVLKNASLDGLKSVEIQNLNFT-------VTNDSV 549
            |||  :::|.......||:.|       :|.   :||   :..|::|.||.:       |...|:
Human   423 VNG--MLQCVAAGFPEPTIDWYFCPGTEQRC---SAS---VLPVDVQTLNSSGPPFGKLVVQSSI 479

  Fly   550 VLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYAL-------LHAHPLGFT--L 605
                .:..|...|...|.|.:.:|:  :|.|..          :|.       :|.|.| ||  |
Human   480 ----DSSAFKHNGTVECKAYNDVGK--TSAYFN----------FAFKGNNKEQIHPHTL-FTPLL 527

  Fly   606 AAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPV 670
            ....|||    |...|..|:  |..:.|.|...|.  ||  ||:      ||.:|.:       .
Human   528 IGFVIVA----GMMCIIVMI--LTYKYLQKPMYEV--QW--KVV------EEINGNN-------Y 569

  Fly   671 IRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLP 735
            :.|               ||.|      .|.|..||.||.:||.|..||.||||:||.|.|.||.
Human   570 VYI---------------DPTQ------LPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLI 613

  Fly   736 RSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPH 800
            :|.  |...|||||:|.....|:..:|:.|::|:..:|.|:||:||||.|:.|||..||.||..:
Human   614 KSD--AAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTIGGPTLVITEYCCY 676

  Fly   801 GNLKDFLKQNRPG-------------------APQRRSDSDG---YLDDKPLIS----------- 832
            |:|.:||::.|..                   ..:..|.||.   |:|.||.:|           
Human   677 GDLLNFLRRKRDSFICSKQEDHAEAALYKNLLHSKESSCSDSTNEYMDMKPGVSYVVPTKADKRR 741

  Fly   833 TQHLGE--------------------KELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYV 877
            :..:|.                    ::|..|::|:|:||.:|||:.||||||||||:|::.|.:
Human   742 SVRIGSYIERDVTPAIMEDDELALDLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRI 806

  Fly   878 MKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPY 942
            .||.||||||||::...|....|.|||:|||||||:....|..:|||||||:.|||:.:.|..||
Human   807 TKICDFGLARDIKNDSNYVVKGNARLPVKWMAPESIFNCVYTFESDVWSYGIFLWELFSLGSSPY 871

  Fly   943 PHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNP 1007
            |.:....:.|..:..|.||..|......:|.:|:.||..:...||||.::|:..:   :|.|.:.
Human   872 PGMPVDSKFYKMIKEGFRMLSPEHAPAEMYDIMKTCWDADPLKRPTFKQIVQLIE---KQISEST 933

  Fly  1008 NDAYLDLS 1015
            |..|.:|:
Human   934 NHIYSNLA 941

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btlNP_729956.1 Ig 143..215 CDD:472250 15/74 (20%)
Ig strand B 160..164 CDD:409570 0/3 (0%)
Ig strand C 175..179 CDD:409570 1/3 (33%)
Ig strand E 197..201 CDD:409570 0/3 (0%)
Ig strand F 211..215 CDD:409570 2/3 (67%)
Ig_3 247..333 CDD:464046 16/104 (15%)
Ig 398..479 CDD:472250 16/82 (20%)
Ig strand B 412..416 CDD:409393 0/3 (0%)
Ig strand C 423..427 CDD:409393 1/5 (20%)
Ig strand E 445..449 CDD:409393 1/3 (33%)
Ig strand F 459..464 CDD:409393 1/4 (25%)
Ig strand G 472..475 CDD:409393 0/2 (0%)
IG_like 492..583 CDD:214653 25/106 (24%)
Ig strand B 503..507 CDD:409444 0/3 (0%)
Ig strand C 516..520 CDD:409444 2/10 (20%)
Ig strand E 549..553 CDD:409444 0/3 (0%)
Ig strand F 563..568 CDD:409444 1/4 (25%)
Ig strand G 576..579 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 135/352 (38%)
KITNP_001372213.1 ig 216..306 CDD:395002 18/108 (17%)
Ig strand B 229..233 CDD:409353 0/3 (0%)
Ig strand E 267..278 CDD:409353 1/10 (10%)
Ig strand F 288..293 CDD:409353 1/4 (25%)
Ig strand G 301..304 CDD:409353 0/2 (0%)
IgI_4_SCFR 312..412 CDD:409446 27/140 (19%)
Ig strand A 312..318 CDD:409446 0/6 (0%)
Ig strand A' 322..327 CDD:409446 3/17 (18%)
Ig strand B 330..340 CDD:409446 4/9 (44%)
Ig strand C 344..351 CDD:409446 1/19 (5%)
Ig strand C' 353..356 CDD:409446 0/2 (0%)
Ig strand D 359..364 CDD:409446 1/4 (25%)
Ig strand E 373..382 CDD:409446 3/11 (27%)
Ig strand F 389..397 CDD:409446 3/7 (43%)
Ig strand G 400..411 CDD:409446 2/10 (20%)
Ig 427..503 CDD:409353 18/87 (21%)
Ig strand C 438..442 CDD:409353 1/3 (33%)
Ig strand E 471..479 CDD:409353 1/7 (14%)
Ig strand F 489..494 CDD:409353 1/4 (25%)
PTKc_Kit 554..929 CDD:270682 147/417 (35%)
Important for interaction with phosphotyrosine-binding proteins 569..571 0/1 (0%)

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