DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and KDR

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_002244.1	Gene:	KDR / 3791	HGNCID:	6307	Length:	1356	Species:	Homo sapiens

Alignment Length:	1107	Identity:	301/1107 - (27%)
Similarity:	428/1107 - (38%)	Gaps:	356/1107 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 VQRTAGGLFQLNCSPMDPDAKGVNISW------------LHNDTQILGGRGRIKLKRW--SLTVG 202
            ::.:.|....|||:.......|::.:|            ::.|.:...|.   ::|::  :||:.
Human   234 IELSVGEKLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGS---EMKKFLSTLTID 295

  Fly   203 QLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDS 267
            .:...|.|.|.| ........:.|.|.:.|    |..|.          :|.|.  .:|.|:|.:
Human   296 GVTRSDQGLYTC-AASSGLMTKKNSTFVRV----HEKPF----------VAFGS--GMESLVEAT 343

  Fly   268 ALE-------------PKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNV 319
            ..|             |:|.|...|                 :|::....|   ....||.:..|
Human   344 VGERVRIPAKYLGYPPPEIKWYKNG-----------------IPLESNHTI---KAGHVLTIMEV 388

  Fly   320 LMEDGGWYICIAENQVGRTVAASYV-------------DLYSPSDT---TTVRTTTTTTVASPIP 368
            ...|.|.|..|..|.:.:...:..|             .|.||.|:   .|.:|.|.|..|.|.|
Human   389 SERDTGNYTVILTNPISKEKQSHVVSLVVYVPPQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPP 453

  Fly   369 -----------TASTGEDNDDDVENP--------------------------------------- 383
                       ..:........|.||
Human   454 HHIHWYWQLEEECANEPSQAVSVTNPYPCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLV 518

  Fly   384 --AAEASG----------GVGPPVFRKELKR-----LQHSL---SGNTVNLACPVYGKA--NITW 426
              ||..|.          |.|..|....:.|     ||..:   ...:|:|.|......  |:||
Human   519 IQAANVSALYKCEAVNKVGRGERVISFHVTRGPEITLQPDMQPTEQESVSLWCTADRSTFENLTW 583

  Fly   427 TK-DKKPLN---RELGVYVQKN----WTLR---FVEATS------------EDSGLYNC----KV 464
            .| ..:||.   .||...|.||    |.|.   |..:|:            :|.|.|.|    :.
Human   584 YKLGPQPLPIHVGELPTPVCKNLDTLWKLNATMFSNSTNDILIMELKNASLQDQGDYVCLAQDRK 648

  Fly   465 CNAWGCIQFDFSVQINDRTRSAPIIVVP-QNQTVKVNGSLVMKCTVYSDLHPTVSWKR------- 521
            .....|:....:|    ..|.||.|... :|||..:..|:.:.||...:..|.:.|.:
Human   649 TKKRHCVVRQLTV----LERVAPTITGNLENQTTSIGESIEVSCTASGNPPPQIMWFKDNETLVE 709

  Fly   522 ---VVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRV 583
               :|||    ||       |.|         ||:|.|..:.||.|||.|.|.||.:....:..:
Human   710 DSGIVLK----DG-------NRN---------LTIRRVRKEDEGLYTCQACSVLGCAKVEAFFII 754

  Fly   584 --VSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTK 646
              ......|||                    :.|:|:|.|....                  |..
Human   755 EGAQEKTNLEI--------------------IILVGTAVIAMFF------------------WLL 781

  Fly   647 KVIIYRP-----GGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLD---- 702
            .|||.|.     |||..:|      .:.::                .||.      |.|||
Human   782 LVIILRTVKRANGGELKTG------YLSIV----------------MDPD------ELPLDEHCE 818

  Fly   703 ------SNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMAS 761
                  |.||.||.:|.||..||.||||:|:.|:|.|:.::...  ..|||||:||..|.::..:
Human   819 RLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKTATC--RTVAVKMLKEGATHSEHRA 881

  Fly   762 LVREMEVMKMIGKHINIINLLGCCSQ-GGPLWVIVEYAPHGNLKDFLKQNR-------------- 811
            |:.|::::..||.|:|::||||.|:: ||||.||||:...|||..:|:..|
Human   882 LMSELKILIHIGHHLNVVNLLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFR 946

  Fly   812 ---------PGAPQRRSD---------SDGYLDDKPLISTQH-----------LGEKELTKFAFQ 847
                     |...:||.|         |.|::::|.|...:.           |..:.|..::||
Human   947 QGKDYVGAIPVDLKRRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQ 1011

  Fly   848 IARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDI-QDTEYYRKNTNGRLPIKWMAPE 911
            :|:|||:||||:||||||||||:|:|:..|:||.|||||||| :|.:|.||. :.|||:||||||
Human  1012 VAKGMEFLASRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKG-DARLPLKWMAPE 1075

  Fly   912 SLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMR 976
            ::.::.|..||||||:|||||||.:.|..|||.:...||....|..|.||..|...:..:|..|.
Human  1076 TIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML 1140

  Fly   977 QCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDEDDGSDTETFRETS 1041
            .|||.|...||||:||||....:||..:......|:.|  |:.||  .|.:||.|...    .||
Human  1141 DCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVL--PISET--LSMEEDSGLSL----PTS 1197

  Fly  1042 PL 1043
            |:
Human  1198 PV 1199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	17/93 (18%)
		IGc2	157..215	CDD:197706	14/71 (20%)
		IG	247..336	CDD:214652	20/101 (20%)
		Ig	258..340	CDD:143165	18/94 (19%)
		I-set	394..479	CDD:254352	28/121 (23%)
		IGc2	408..469	CDD:197706	22/89 (25%)
		IG_like	492..583	CDD:214653	28/101 (28%)
		Ig	507..583	CDD:299845	24/85 (28%)
		PKc_like	700..1000	CDD:304357	148/354 (42%)
		TyrKc	712..996	CDD:197581	140/328 (43%)
KDR	NP_002244.1	Ig	41..109	CDD:299845
		IG_like	231..324	CDD:214653	17/93 (18%)
		Ig1_VEGFR	239..326	CDD:143270	18/94 (19%)
		IG_like	340..417	CDD:214653	17/96 (18%)
		Ig2_VEGFR-2	348..417	CDD:143272	15/88 (17%)
		Ig_2	551..661	CDD:290606	25/109 (23%)
		IG	565..661	CDD:214652	23/95 (24%)
		I-set	667..754	CDD:254352	30/106 (28%)
		IGc2	680..744	CDD:197706	23/83 (28%)
		PTKc_VEGFR2	826..1167	CDD:270681	146/343 (43%)
		Pkinase_Tyr	834..1160	CDD:285015	140/328 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1274..1318
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810