DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Fgfrl1

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_954545.1	Gene:	Fgfrl1 / 360903	RGDID:	735156	Length:	529	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	150/571 - (26%)
Similarity:	212/571 - (37%)	Gaps:	166/571 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   247 PRNTSIALGDNVSIECLLEDSALEPKIT-WLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDE 310
            ||..: .||..|.::|.:|..  .|.:| |...|.  .|.....|.|..
  Rat    33 PRQVA-RLGRTVRLQCPVEGD--PPPLTMWTKDGR--TIHSGWSRFRVL---------------- 76

  Fly   311 PQVLRLGNVLMEDGGWYICIAENQVGRTVAASY----VDLYSPSDTTTVRTTTTTTVASPIPTAS 371
            ||.|::..|..||.|.|:|.|.|..| :::.:|    :|..||..            .:|.|..|
  Rat    77 PQGLKVKEVEAEDAGVYVCKATNGFG-SLSVNYTLIIMDDISPGK------------ENPGPGGS 128

  Fly   372 TGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLS---GNTVNLACPVYG--KANITWTKDKK 431
            :| ..:|.|....|.       |.|.:..|..:..::   |::|.|.|...|  :.:|.|.||.:
  Rat   129 SG-GQEDPVSQQWAR-------PRFTQPSKMRRRVIARPVGSSVRLKCVASGHPRPDIMWMKDDQ 185

  Fly   432 PLNR-ELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPII--VVPQ 493
            .|.| |...:.:|.|||.......||||.|.|:|.|..|.|...:.|.:..||||.|::  ..|.
  Rat   186 TLTRLEASEHRKKKWTLSLKNLKPEDSGKYTCRVSNRAGAINATYKVDVIQRTRSKPVLTGTHPV 250

  Fly   494 NQTVKVNGSLVMKCTVYSDLHPTVSW-KRVVL-----KNASLD--GLKSVEIQNLNFTVTNDSVV 550
            |.||...|:...:|.|.||:.|.:.| |||..     .|:::|  |.|.|.:...:.....|...
  Rat   251 NTTVDFGGTTSFQCKVRSDVKPVIQWLKRVEYGSEGRHNSTIDVGGQKFVVLPTGDVWSRPDGSY 315

  Fly   551 LT---LRNVTFDQEGWYTCLASSGLGRSNSSVYLRVV----SPLPPLEIYALLHAHPLGFTLAAI 608
            |.   :.....|..|.|.||.::.:|.|..|.:|.|:    .|.||:       ||....|....
  Rat   316 LNKLLISRARQDDAGMYICLGANTMGYSFRSAFLTVLPDPKPPGPPV-------AHSSSTTSLPW 373

  Fly   609 TIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQW---TKK----------VIIYRPGGEEGSG 660
            .:|.....|:.||                :.||..|   |||          |..:||.|.  |.
  Rat   374 PVVIGIPAGAVFI----------------LGTVLLWLCQTKKKPCAPASTLPVPGHRPPGT--SR 420

  Fly   661 CSSGDLQMPVIRI---EKQRTTV---------STTG-------------------------TGGT 688
            ..|||..:|.:.:   |:..:|:         ||.|                         .||
  Rat   421 ERSGDKDLPSLAVGICEEHGSTMAPQHILAPGSTAGPKLYPKLYTDVHTHTHTHTCTHTLSCGG- 484

  Fly   689 DPAQGFNEYEFPLD----SNWEI---------PRQQLSLGSILGEGAFGRV 726
               ||.:....||.    :|.:.         ||||  :|.|...|  |||
  Rat   485 ---QGSSAPACPLSVLNTANLQALCPEVGVWGPRQQ--VGRIENNG--GRV 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	25/89 (28%)
		Ig	258..340	CDD:143165	22/82 (27%)
		I-set	394..479	CDD:254352	30/90 (33%)
		IGc2	408..469	CDD:197706	24/66 (36%)
		IG_like	492..583	CDD:214653	30/101 (30%)
		Ig	507..583	CDD:299845	25/86 (29%)
		PKc_like	700..1000	CDD:304357	13/40 (33%)
		TyrKc	712..996	CDD:197581	6/15 (40%)
Fgfrl1	NP_954545.1	I-set	29..112	CDD:400151	27/100 (27%)
		Ig strand A'	35..38	CDD:409353	0/3 (0%)
		Ig strand B	41..50	CDD:409353	2/8 (25%)
		Ig strand C	56..61	CDD:409353	2/4 (50%)
		Ig strand C'	64..67	CDD:409353	0/4 (0%)
		Ig strand D	72..77	CDD:409353	2/20 (10%)
		Ig strand E	78..84	CDD:409353	2/5 (40%)
		Ig strand F	91..99	CDD:409353	4/7 (57%)
		Ig strand G	102..112	CDD:409353	2/10 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..152		12/54 (22%)
		IgI_2_FGFRL1-like	143..234	CDD:409442	30/90 (33%)
		Ig strand B	164..168	CDD:409442	2/3 (67%)
		Ig strand C	177..181	CDD:409442	1/3 (33%)
		Ig strand E	200..204	CDD:409442	3/3 (100%)
		Ig strand F	214..219	CDD:409442	2/4 (50%)
		Ig strand G	227..230	CDD:409442	0/2 (0%)
		Ig	242..350	CDD:416386	30/107 (28%)
		Ig strand A	242..245	CDD:409353	1/2 (50%)
		Ig strand A'	249..253	CDD:409353	2/3 (67%)
		Ig strand B	261..268	CDD:409353	2/6 (33%)
		Ig strand C	272..279	CDD:409353	2/6 (33%)
		Ig strand D	304..309	CDD:409353	0/4 (0%)
		Ig strand E	317..322	CDD:409353	0/4 (0%)
		Ig strand F	330..338	CDD:409353	4/7 (57%)
		Ig strand G	341..349	CDD:409353	3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..427		8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810