DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and fgfr1a

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_009302578.1	Gene:	fgfr1a / 30705	ZFINID:	ZDB-GENE-980526-255	Length:	811	Species:	Danio rerio

Alignment Length:	834	Identity:	289/834 - (34%)
Similarity:	427/834 - (51%)	Gaps:	121/834 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 PGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRM 308
            |..|.:.::..|:.:.:.|..::..  .|:||. |.....:|....||| ..|:.::..
Zfish    35 PAEPTSYTLDSGEKLELSCKAKEDT--QKVTWT-KDLVPLVDGEHTRLR-NDQMEIEKV------ 89

  Fly   309 DEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTG 373
             ||          .|.|.|.|.|:.     :.:::.:.::.|.|
Zfish    90 -EP----------TDSGLYACFAQG-----LNSNHTEYFNISVT--------------------- 117

  Fly   374 EDNDDDVENPAAEA--SGGVGPPVF------RKELKRLQHSLSGNTVNLACPVYGKANIT--WTK 428
             |.:|:|::.:.||  |.....|:.      .|..|:|....:..||...|...|....|  |.|
Zfish   118 -DEEDEVDSSSEEAKLSNDQNLPMAPVWAQPDKMEKKLHAVPASKTVKFRCQANGNPTPTLKWLK 181

  Fly   429 DKKPLNREL---GVYVQKN-WTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPII 489
            :.|...|:.   |..|::: ||:........|.|.|.|.|.|..|.|...:.:.:.:|:...||:
Zfish   182 NGKEFKRDQRIGGFKVREHMWTIIMESVVPSDRGNYTCLVENRHGSINHTYQLDVVERSPHRPIL 246

  Fly   490 V--VPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASL---DGLKSVEIQNLNFTVTNDSV 549
            .  :|.|:|..|...:..:|.|:||..|.:.|.:.:..|.|.   |||..|.....:...::|:.
Zfish   247 QAGLPANRTAVVGSDVEFECKVFSDPQPHIQWLKHIEVNGSRYGPDGLPYVRALKNSGVNSSDTQ 311

  Fly   550 VLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPL---PPLEI----YALLHAHPLGFTLAA 607
            ||||.|||.:|.|.|.|..|:.:|::|.|.:|.||..|   ||.::    |..:..:.:||.|..
Zfish   312 VLTLYNVTEEQSGEYICKVSNYIGQANQSAWLTVVKHLQAVPPTQLPNQTYLEVLIYCVGFFLIC 376

  Fly   608 ITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRP---GGEEGSGCSSGDLQMP 669
            :      ::|:|.:..|....::.......  .||:..|.:.:.|.   ..:..|...||.:.:.
Zfish   377 V------MVGTAVLAKMHSSAKKSDFNSQL--AVHKLAKSIPLRRQVTVSVDSSSSMHSGGMLVR 433

  Fly   670 VIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGL 734
            ..|:          .:.|:....|.:|||.|.|..||:.|.:|.||..||||.||:|:||||.|:
Zfish   434 PSRL----------SSSGSPMLSGVSEYELPQDPRWEVQRDRLVLGKPLGEGCFGQVMMAEAMGM 488

  Fly   735 PRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAP 799
            .:......|.|||||:|.:.|:.|::.|:.|||:||:||||.|||||||.|:|.|||:||||:|.
Zfish   489 DKEKPNRITKVAVKMLKSDATEKDLSDLISEMEMMKIIGKHKNIINLLGACTQDGPLYVIVEFAA 553

  Fly   800 HGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRD 864
            .|||:::|:..||...:       |..:...:..:::..|:|...|:|:|||||||||::|||||
Zfish   554 KGNLREYLRVRRPPGME-------YCYNPDQVPVENMSIKDLVSCAYQVARGMEYLASKKCIHRD 611

  Fly   865 LAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGV 929
            ||||||||::..|||||||||||||...:||:|.||||||:||||||:|.::.|..||||||:||
Zfish   612 LAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGV 676

  Fly   930 LLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVE 994
            |||||.|.|..|||.: ..|||:..|..|.||::|:.|:..:|::||.|||.....||||.:|||
Zfish   677 LLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDRPSTCTHELYMMMRDCWHAVPSQRPTFKQLVE 740

  Fly   995 SFDGILQQASSNPNDAYLDLSMPMLETPP----------SSGDE-----DDGSD 1033
            ..|..|...|   |..|||||:.:.:..|          |||::     |.|:|
Zfish   741 DLDRTLSMTS---NQEYLDLSVSLDQFSPNFPDTRSSTCSSGEDSVFSHDAGAD 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	19/88 (22%)
		Ig	258..340	CDD:143165	17/81 (21%)
		I-set	394..479	CDD:254352	25/96 (26%)
		IGc2	408..469	CDD:197706	19/66 (29%)
		IG_like	492..583	CDD:214653	33/93 (35%)
		Ig	507..583	CDD:299845	29/78 (37%)
		PKc_like	700..1000	CDD:304357	160/299 (54%)
		TyrKc	712..996	CDD:197581	154/283 (54%)
fgfr1a	XP_009302578.1	Ig	28..116	CDD:416386	20/106 (19%)
		Ig strand A	28..31	CDD:409353
		Ig strand A'	38..44	CDD:409353	1/5 (20%)
		Ig strand B	47..57	CDD:409353	1/9 (11%)
		Ig strand C	61..66	CDD:409353	3/5 (60%)
		Ig strand C'	69..71	CDD:409353	0/1 (0%)
		Ig strand D	76..80	CDD:409353	1/3 (33%)
		Ig strand E	83..88	CDD:409353	1/4 (25%)
		Ig strand F	94..103	CDD:409353	4/8 (50%)
		Ig strand G	106..116	CDD:409353	0/9 (0%)
		Ig	142..236	CDD:416386	24/93 (26%)
		Ig strand A	142..145	CDD:409353	0/2 (0%)
		Ig strand A'	153..158	CDD:409353	1/4 (25%)
		Ig strand B	162..170	CDD:409353	3/7 (43%)
		Ig strand C	176..181	CDD:409353	2/4 (50%)
		Ig strand C'	184..186	CDD:409353	1/1 (100%)
		Ig strand D	195..198	CDD:409353	0/2 (0%)
		Ig strand E	202..207	CDD:409353	2/4 (50%)
		Ig strand F	216..223	CDD:409353	3/6 (50%)
		Ig strand G	226..236	CDD:409353	2/9 (22%)
		Ig	244..345	CDD:416386	35/100 (35%)
		Ig strand A	244..247	CDD:409353	2/2 (100%)
		Ig strand A'	251..255	CDD:409353	2/3 (67%)
		Ig strand B	263..270	CDD:409353	2/6 (33%)
		Ig strand C	274..281	CDD:409353	2/6 (33%)
		Ig strand D	296..301	CDD:409353	1/4 (25%)
		Ig strand E	311..316	CDD:409353	3/4 (75%)
		Ig strand F	324..332	CDD:409353	3/7 (43%)
		Ig strand G	335..343	CDD:409353	3/7 (43%)
		FGFR3_TM	358..387	CDD:407957	6/34 (18%)
		PTKc_FGFR1	452..753	CDD:270678	164/311 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1538
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm6455
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.900