DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and flt4

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_571020.2	Gene:	flt4 / 30121	ZFINID:	ZDB-GENE-980526-326	Length:	1368	Species:	Danio rerio

Alignment Length:	1152	Identity:	302/1152 - (26%)
Similarity:	464/1152 - (40%)	Gaps:	324/1152 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 ENSPRQRHLLSDMDITLQCVRPM-------AKWFYEDKFQLR-----------------ATLLRL 77
            |:||.:  |:....:.|.|...:       .:|.|..|.:.|                 :::|.:
Zfish   256 EDSPVE--LMQGESLVLNCTALVDFNTGVDFQWDYPGKKENRLASLQPLRNVLDEATEISSILSI 318

  Fly    78 ERAQSGNSGNYGCLDSQNRWYN--------ISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQ 134
            ......:||.|.|      |.|        .::|:.|::|       |:.|
Zfish   319 RNIHLDDSGYYTC------WANTLEMKRELTTVVIVHEKP-------FISL-------------- 356

  Fly   135 PLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNISWLHNDTQILG-GRGRIKLKRWS 198
               :.|:..:::  .|..|::.....:::..| .|:     |.|..|...|.. ...|.|:::.|
Zfish   357 ---DYRNGSVIE--AKEGQKSVRLSVKVSAYP-SPE-----IQWYKNGKLISSKNSSRFKVQQHS 410

  Fly   199 LTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLE-------------VISRKHTVPMLKPGYPRNT 250
            |.:..:..:|||.|...|       :::|..||             .|..|...|      |.|.
Zfish   411 LQIRDVCKQDAGEYMLVL-------KNSPAALEKRLNFTLIVNVPPQIHEKEAAP------PTNL 462

  Fly   251 SIALGDNVSIECLLEDSALEPKITWLHKG----NADNIDDLLQRL--REQSQL------------ 297
             ...|....:.| ..|.:....|:|..:.    :.:.....|:|.  |:||..
Zfish   463 -YGKGTRQILTC-TADGSPPASISWQWRPWSPCDLERTRRALRRRGGRDQSPFCHNWMDLDPEHA 525

  Fly   298 --PVDVTRLITRMDEPQVLRLGNVLMEDG---GWYICIAENQVGRTVAASYVDLYSPSDTTTVRT 357
              |::....:|:|.:.:...:|.|::::.   ..|.|:|||:||:.....|  .|
Zfish   526 VNPIESIDTLTQMVDGKEKTVGRVVIQNASVPAMYKCLAENKVGKDERLIY--FY---------- 578

  Fly   358 TTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPV--YG 420
              .||:                             |..|..|::..:..|..:.|.|.|..  :.
Zfish   579 --VTTI-----------------------------PEGFDIEMEPSEDPLEQDLVQLKCNADNFT 612

  Fly   421 KANITWTK----------DKKPLNRELGVYVQ---------KNWTLR--FVEATSEDSGLYNCKV 464
            ..|:.|.:          |.|.|: :...:::         .||.|:  ......:|.|.|.|:|
Zfish   613 YENLRWYRLDPQTVPPELDCKSLH-QYATFLEGQLSFQTTSNNWVLQLNITNIQLQDEGNYVCEV 676

  Fly   465 CNAWGCIQFDFSVQINDRTRSAP-IIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNAS 528
            .|....::......|..:...|| ....|.|.||.|:.||.|.|.|.....|.:||.:   .|..
Zfish   677 QNRRTGVKHCHRKYIPVKAMEAPRYRHNPTNHTVNVSESLQMNCDVEGTPFPQLSWFK---DNQP 738

  Fly   529 LDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIY 593
            |..:..:.:|:.|.|       |:::.|..:..|.|||.|.:..|...||..:.|:.......:.
Zfish   739 LHQISGILLQDSNRT-------LSIQRVREEDAGLYTCSACNQKGCVQSSATVSVIGSDDKTNVE 796

  Fly   594 ALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEG 658
            .::        |....::|:|.                            |...::|:
Zfish   797 IVI--------LIGTGVIAIFF----------------------------WVLLLVIF------- 818

  Fly   659 SGCSSGDLQMPVIRIEKQRTTVSTTGTG--------GTDPAQGFNEYEFPLDSN-WEIPRQQLSL 714
              |:            .:|...:...||        |..|.:...|| .|.||: |||.|.:|.|
Zfish   819 --CN------------VKRVNPADIKTGYLSIIMDPGEVPLEEQCEY-LPYDSSQWEISRDRLRL 868

  Fly   715 GSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINII 779
            |.:||.||||:|:.|...|  ...:.:...|||||:||..|.::..:|:.|::::..||.|:|::
Zfish   869 GKVLGHGAFGKVIEASIFG--HDKKSSANTVAVKMLKEGATASEHKALMSELKILIHIGNHLNVV 931

  Fly   780 NLLGCCSQ-GGPLWVIVEYAPHGNLKDFLKQN-------RPGAPQRRSDSDGYLD---------- 826
            ||||.|:: .|||.|||||..:|||.:||:..       |..:|:.:|.....::
Zfish   932 NLLGACTKPNGPLMVIVEYCKYGNLSNFLRAKREFFLPYRDRSPKTQSQVRRMIEAGQASQSEHQ 996

  Fly   827 ------DKPLISTQHLGEKELT-----KFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKI 880
                  :.|.::...|.:..||     .::||:|||||:||||:||||||||||:|:|:..|:||
Zfish   997 PSTSSTNPPRVTVDDLWKTPLTIEDLICYSFQVARGMEFLASRKCIHRDLAARNILLSENNVVKI 1061

  Fly   881 ADFGLARDI-QDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPH 944
            .|||||||| :|.:|.||. |.|||:|||||||:.:|.|.|||||||:|||||||.:.|..|||.
Zfish  1062 CDFGLARDIYKDPDYVRKG-NARLPLKWMAPESIFDKVYTSQSDVWSFGVLLWEIFSLGASPYPG 1125

  Fly   945 ILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPND 1009
            |...|:....|..|.||..|...|..||.:|..||..|...||||..|||....:||:.
Zfish  1126 IQIDEDFCKRLKDGTRMRAPDNASPEIYGIMLACWQGEPRERPTFPALVEILGDLLQEN------ 1184

  Fly  1010 AYLDLSMPMLETPPSSGDEDDGSDTETFR-----------ETSPLRY 1045
                 |:|.:....|...||||....:.|           .|.|.||
Zfish  1185 -----SLPEIPFNVSQSSEDDGFSQASSRPPSQEEIRLACNTLPTRY 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	20/96 (21%)
		IGc2	157..215	CDD:197706	14/58 (24%)
		IG	247..336	CDD:214652	22/111 (20%)
		Ig	258..340	CDD:143165	21/104 (20%)
		I-set	394..479	CDD:254352	20/107 (19%)
		IGc2	408..469	CDD:197706	17/83 (20%)
		IG_like	492..583	CDD:214653	28/90 (31%)
		Ig	507..583	CDD:299845	20/75 (27%)
		PKc_like	700..1000	CDD:304357	148/330 (45%)
		TyrKc	712..996	CDD:197581	141/313 (45%)
flt4	NP_571020.2	IG_like	258..348	CDD:214653	17/97 (18%)
		Ig1_VEGFR	265..350	CDD:143270	14/90 (16%)
		IG_like	362..445	CDD:214653	20/97 (21%)
		Ig	373..445	CDD:299845	18/84 (21%)
		Ig	602..685	CDD:143165	17/83 (20%)
		IG	602..678	CDD:214652	16/76 (21%)
		I-set	705..786	CDD:254352	28/90 (31%)
		IGc2	714..776	CDD:197706	20/71 (28%)
		PKc_like	858..1184	CDD:304357	147/328 (45%)
		Pkinase_Tyr	866..1177	CDD:285015	141/313 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	978..1007		2/28 (7%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1190..1212		6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910