DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Kdr

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_037194.2	Gene:	Kdr / 25589	RGDID:	2965	Length:	1343	Species:	Rattus norvegicus

Alignment Length:	1269	Identity:	317/1269 - (24%)
Similarity:	477/1269 - (37%)	Gaps:	413/1269 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LGCDYGHHRCY---IDVT---------------------------VENSPRQ-----RHLLSDMD 50
            :|.|.|.::|:   .||:                           .||..:.     |..:|:::
  Rat    94 VGNDTGAYKCFYRDTDVSSIVYVYVQDHRSPFIASVSDEHGIVYITENKNKTVVIPCRGSISNLN 158

  Fly    51 ITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNISLVVGHKEPVGNDIA 115
            ::| |.|...|.|..|                   ||....||:..:...|.::.:...|..:
  Rat   159 VSL-CARYPEKRFVPD-------------------GNRISWDSEKGFTIPSYMISYAGMVFCE-- 201

  Fly   116 SFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNISW-- 178
              .|:.|...  :|.::...:...|...::...|..::.:||....|||:.......|::.||
  Rat   202 --AKINDETY--QSIMYIVLVVGYRIYDVVLSPPHEIELSAGEKLVLNCTARTELNVGLDFSWQF 262

  Fly   179 ----------LHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVI 233
                      ::.|.:.|.|. ..|:...:||:..:...|.|.|.| ........:.|.|.:.|
  Rat   263 PSSKHQHKKIVNRDVKSLPGT-VAKMFLSTLTIDSVTKSDQGEYTC-TAYSGLMTKKNKTFVRV- 324

  Fly   234 SRKHTVPMLKPGYPRNTSI--ALGDNVSIEC-LLEDSALEPKITWLHKGNADNIDDLLQRLREQS 295
               ||.|.:..|....:.:  .:|..|.|.. .|...|  |.|.|...|.
  Rat   325 ---HTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYPA--PDIKWYRNGR--------------- 369

  Fly   296 QLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVD-------------LY 347
              |::....:...||   |.:..|...|.|.|..|..|.:.....:..|.             |.
  Rat   370 --PIESNYTMIVGDE---LTIMEVSERDAGNYTVILTNPISMEKQSHMVSLVVNVPPQIGEKALI 429

  Fly   348 SPSDT---TTVRTTTTTTVASP----------IPTASTGEDNDDDVENPAAEASGGVGPPVFRKE 399
            ||.|:   .|::|.|.|..|:|          :..|.:...:..:              |...||
  Rat   430 SPMDSYQYGTMQTLTCTVYANPPLHHIQWYWQLEEACSYRPSQTN--------------PYTCKE 480

  Fly   400 LKRLQHSLSGNTVNLA-----------------------------CPVYGKA------------- 422
            .:.::....||.:.:.                             |....||
  Rat   481 WRHVKDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEAINKAGRGERVISFHVIR 545

  Fly   423 ------------------------------NITWTK------------DKKPLNRELGVYVQKNW 445
                                          |:||.|            ...|:.:.|....:.|.
  Rat   546 GPEITVQPATQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTPVCKNLDALWKLNG 610

  Fly   446 T-----------LRFVEATSEDSGLYNCKVCNAWG-------CIQFDFSVQINDRTRSAPIIVVP 492
            |           :.|..|:.:|.|.|   ||:|..       |:    ..|:....|.||:|...
  Rat   611 TVFSNSTNDILIVAFQNASLQDQGNY---VCSAQDKKTKKRHCL----VKQLVILERMAPMITGN 668

  Fly   493 -QNQTVKVNGSLVMKCTVYSDLHPTVSWKR----------VVLKNASLDGLKSVEIQNLNFTVTN 546
             :|||..:..::.:.|....:..|.::|.:          :|||    ||       |.|
  Rat   669 LENQTTTIGETIEVVCPTSGNPTPLITWFKDNETLVEDSGIVLK----DG-------NRN----- 717

  Fly   547 DSVVLTLRNVTFDQEGWYTCLASSGLG--RSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAIT 609
                ||:|.|..:..|.|||.|.:.||  |:.:...:........||:
  Rat   718 ----LTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEV----------------- 761

  Fly   610 IVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIE 674
               :.|:|:|.|....                  |...||:.|    .....:.|:|:...:.|.
  Rat   762 ---IILVGTAVIAMFF------------------WLLLVIVLR----TVKRANEGELKTGYLSIV 801

  Fly   675 KQRTTVSTTGTGGTDPAQGFNEYEFPLD----------SNWEIPRQQLSLGSILGEGAFGRVVMA 729
                         .||.      |.|||          |.||.||.:|.||..||.||||:|:.|
  Rat   802 -------------MDPD------ELPLDERCERLPYDASKWEFPRDRLKLGKPLGRGAFGQVIEA 847

  Fly   730 EAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQ-GGPLWV 793
            :|.|:.::...  ..|||||:||..|.::..:|:.|::::..||.|:|::||||.|:: ||||.|
  Rat   848 DAFGIDKTATC--KTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTKPGGPLMV 910

  Fly   794 IVEYAPHGNLKDFLKQNR--------PGAP---------------QRRSD---------SDGYLD 826
            |||:...|||..:|:..|        .||.               :||.|         |.|:::
  Rat   911 IVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRSGKDYVGELSVDLKRRLDSITSSQSSASSGFVE 975

  Fly   827 DKPLIST-QHLGEKELTK----------FAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKI 880
            :|.|... :....:||.|          ::||:|:|||:||||:||||||||||:|:|:..|:||
  Rat   976 EKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARNILLSEKNVVKI 1040

  Fly   881 ADFGLARDI-QDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPH 944
            .|||||||| :|.:|.||. :.|||:||||||::.::.|..||||||:|||||||.:.|..|||.
  Rat  1041 CDFGLARDIYKDPDYVRKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWEIFSLGASPYPG 1104

  Fly   945 ILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPND 1009
            :...||....|..|.||..|...:..:|..|..|||.:...||.|:||||....:||..:.....
  Rat  1105 VKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPAFSELVEHLGNLLQANAQQDGK 1169

  Fly  1010 AYLDLSMPMLETPPSSGDEDDGSDTETFRETSPL 1043
            .|:.|  ||.||  .|.:||.|...    .|||:
  Rat  1170 DYIVL--PMSET--LSMEEDSGLSL----PTSPV 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	21/94 (22%)
		IGc2	157..215	CDD:197706	16/69 (23%)
		IG	247..336	CDD:214652	19/91 (21%)
		Ig	258..340	CDD:143165	18/82 (22%)
		I-set	394..479	CDD:254352	25/186 (13%)
		IGc2	408..469	CDD:197706	21/155 (14%)
		IG_like	492..583	CDD:214653	25/103 (24%)
		Ig	507..583	CDD:299845	22/87 (25%)
		PKc_like	700..1000	CDD:304357	148/354 (42%)
		TyrKc	712..996	CDD:197581	140/328 (43%)
Kdr	NP_037194.2	Ig	224..325	CDD:416386	22/106 (21%)
		Ig strand A	224..228	CDD:409353	0/3 (0%)
		Ig strand A'	234..238	CDD:409353	0/3 (0%)
		Ig strand B	240..249	CDD:409353	3/8 (38%)
		Ig strand C	256..261	CDD:409353	1/4 (25%)
		Ig strand C'	264..266	CDD:409353	0/1 (0%)
		Ig strand D	270..278	CDD:409353	1/7 (14%)
		Ig strand E	286..294	CDD:409353	2/7 (29%)
		Ig strand F	304..310	CDD:409353	2/6 (33%)
		Ig strand G	315..321	CDD:409353	1/5 (20%)
		Ig	329..417	CDD:416386	21/109 (19%)
		Ig strand A	329..332	CDD:409353	0/2 (0%)
		Ig strand A'	339..343	CDD:409353	0/3 (0%)
		Ig strand B	345..356	CDD:409353	3/10 (30%)
		Ig strand C	360..366	CDD:409353	3/5 (60%)
		Ig strand C'	368..371	CDD:409353	1/19 (5%)
		Ig strand D	376..379	CDD:409353	0/2 (0%)
		Ig strand E	381..386	CDD:409353	3/7 (43%)
		Ig strand F	394..402	CDD:409353	3/7 (43%)
		Ig strand G	408..417	CDD:409353	1/8 (13%)
		Ig_3	547..641	CDD:404760	15/96 (16%)
		IGc2	676..740	CDD:197706	19/83 (23%)
		Ig strand B	680..684	CDD:409353	0/3 (0%)
		Ig strand C	693..697	CDD:409353	0/3 (0%)
		Ig strand E	716..720	CDD:409353	2/12 (17%)
		Ig strand F	730..735	CDD:409353	3/4 (75%)
		VEGFR-2_TMD	755..789	CDD:375470	10/75 (13%)
		PTKc_VEGFR2	822..1163	CDD:270681	146/343 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1267..1314
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	51	1.000	Domainoid score	I11262
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810