DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Pdgfra

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_036934.1	Gene:	Pdgfra / 25267	RGDID:	3284	Length:	1088	Species:	Rattus norvegicus

Alignment Length:	1062	Identity:	277/1062 - (26%)
Similarity:	425/1062 - (40%)	Gaps:	308/1062 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPES 129
            |:...|..|:|.:..|.:.::|.|.|      :|| .......|..|..|..:|        |:.
  Rat    74 ENNSSLFVTVLEVVNASAAHTGWYTC------YYN-HTQTEESEIEGRHIYIYV--------PDP 123

  Fly   130 DLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNISWLHNDTQILGGRGRIKL 194
            |:.|.||..:.||.:::.....:         :.|...|||.:..    |||:       ||:..
  Rat   124 DMAFVPLGMTDSLVIVEEDDSAI---------IPCRTTDPDTEVT----LHNN-------GRLVP 168

  Fly   195 KRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVS 259
            ..:....|.......|.|.||..|..  :....::..|.:.|.|..:......|.|....|:.:.
  Rat   169 ASYDSRQGFNGTFSVGPYICEATVRG--RTFKTSEFNVYALKATSELNLEMDTRQTVYKAGETIV 231

  Fly   260 IECLLEDSALEPKITWLHKGNADN--IDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLME 322
            :.|.:.::.: ..:.|.:.|...|  |..|     |:.:||  ..:|:..:..|:      ..::
  Rat   232 VTCAVFNNEV-VDLQWTYPGEVRNKGITML-----EEIKLP--SIKLVYTLTVPK------ATVK 282

  Fly   323 DGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEA 387
            |.|.|.|.|...                 |..|:...|.|::
  Rat   283 DSGDYECAARQA-----------------TKEVKEMKTVTIS----------------------- 307

  Fly   388 SGGVGPPVFRKELKRLQHSLSG-NTVNL--------ACPVYGKANITWTKDKKPLNR---ELGVY 440
                   |..|...:::.:... .||||        ....|....|:|.||...|..   |:...
  Rat   308 -------VHEKGFVQIRPTFGHLETVNLHQVREFVVEVQAYPTPRISWLKDNLTLIENLTEITTD 365

  Fly   441 VQKNWTLRF------VEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKV 499
            ||::...|:      :.|..||||.|...|.|......:.|.:.          .:||.:....|
  Rat   366 VQRSQETRYQSKLKLIRAKEEDSGHYTIIVQNDDDMKSYTFELS----------TLVPASILELV 420

  Fly   500 N------GSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFTV--TNDSVVLTLRNV 556
            :      |...::||......|.:.|  ::.|:     :|... .:.::||  :|.|.::|
  Rat   421 DDHHGSGGGQTVRCTAEGTPLPNIEW--MICKD-----IKKCN-NDTSWTVLASNVSNIIT---- 473

  Fly   557 TFDQEGWYT-----------------CLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFT 604
            .|.|.|..|                 |||.:.||..|..  |::|:|....|:           |
  Rat   474 EFHQRGRSTVEGRVSFAKVEETIAVRCLAKNDLGIGNRE--LKLVAPTLRSEL-----------T 525

  Fly   605 LAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMP 669
            :||..:|.|.::..:.|..                        |:|::              |.|
  Rat   526 VAAAVLVLLVIVIVSLIVL------------------------VVIWK--------------QKP 552

  Fly   670 VIRIEKQRTTVSTTGTGG-----TDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMA 729
              |.|.:...:.:....|     .||.|      .|.||.||.||..|.||.|||.||||:||..
  Rat   553 --RYEIRWRVIESISPDGHEYIYVDPMQ------LPYDSRWEFPRDGLVLGRILGSGAFGKVVEG 609

  Fly   730 EAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVI 794
            .|.||.||..:.:  |||||:|.....::..:|:.|:::|..:|.|:||:||||.|::.||:::|
  Rat   610 TAYGLSRSQPVMK--VAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTKSGPIYII 672

  Fly   795 VEYAPHGNLKDFLKQNR-------PGAPQRRSDSDG---------------------YLDDKPLI 831
            .||..:|:|.::|.:||       |..|::..|..|                     |:|.|...
  Rat   673 TEYCFYGDLVNYLHKNRDSFMSRHPEKPKKDLDIFGLNPADESTRSYVILSFENNGDYVDMKQAD 737

  Fly   832 STQH---LGEKELTK--------------------------------------------FAFQIA 849
            :||:   |..||::|                                            |.:|:|
  Rat   738 TTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEAKNLLSDDDSEGLTLLDLLSFTYQVA 802

  Fly   850 RGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDI-QDTEYYRKNTNGRLPIKWMAPESL 913
            ||||:|||:.|:||||||||||::.|.::||.|||||||| .|:.|..|.:. .||:|||||||:
  Rat   803 RGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSKGST-FLPVKWMAPESI 866

  Fly   914 QEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQC 978
            .:..|.:.|||||||||||||.:.|..|||.::.....|:.:.:|.||.||...:..:|.:|.||
  Rat   867 FDNLYTTLSDVWSYGVLLWEIFSLGGTPYPGMMVDSTFYNKIKSGYRMAKPDHATSEVYEIMVQC 931

  Fly   979 WHFESCARPTFAELVESFDGIL 1000
            |:.|...||:|..|.|..:.:|
  Rat   932 WNSEPEKRPSFYHLSEIVENLL 953

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	15/82 (18%)
		IGc2	157..215	CDD:197706	12/57 (21%)
		IG	247..336	CDD:214652	19/90 (21%)
		Ig	258..340	CDD:143165	16/83 (19%)
		I-set	394..479	CDD:254352	25/102 (25%)
		IGc2	408..469	CDD:197706	22/78 (28%)
		IG_like	492..583	CDD:214653	25/115 (22%)
		Ig	507..583	CDD:299845	22/94 (23%)
		PKc_like	700..1000	CDD:304357	144/375 (38%)
		TyrKc	712..996	CDD:197581	137/359 (38%)
Pdgfra	NP_036934.1	Ig_3	27..99	CDD:404760	7/24 (29%)
		Ig	211..309	CDD:416386	23/158 (15%)
		Ig strand A	211..215	CDD:409353	0/3 (0%)
		Ig strand A'	222..226	CDD:409353	1/3 (33%)
		Ig strand B	228..237	CDD:409353	1/8 (13%)
		Ig strand C	242..247	CDD:409353	0/4 (0%)
		Ig strand C'	250..252	CDD:409353	1/1 (100%)
		Ig strand D	256..264	CDD:409353	3/12 (25%)
		Ig strand E	268..276	CDD:409353	1/7 (14%)
		Ig strand F	286..292	CDD:409353	2/5 (40%)
		Ig strand G	297..303	CDD:409353	1/5 (20%)
		Ig4_PDGFR	312..412	CDD:409445	23/109 (21%)
		Ig strand B	332..336	CDD:409445	0/3 (0%)
		Ig strand C	345..349	CDD:409445	1/3 (33%)
		Ig strand E	376..380	CDD:409445	0/3 (0%)
		Ig strand F	390..395	CDD:409445	1/4 (25%)
		Ig strand G	403..406	CDD:409445	0/2 (0%)
		PTKc_PDGFR_alpha	554..955	CDD:173653	150/409 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1088
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810