DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Fgfr4

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_006253668.1	Gene:	Fgfr4 / 25114	RGDID:	2612	Length:	801	Species:	Rattus norvegicus

Alignment Length:	774	Identity:	282/774 - (36%)
Similarity:	400/774 - (51%)	Gaps:	112/774 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 LRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDD 378
            |.:.:.|.||.|.|:|:|...:                  ||....|..:...:|:.     |::
  Rat    83 LEIASFLPEDAGRYLCLARGSM------------------TVVHNLTLIMDDSLPSI-----NNE 124

  Fly   379 DVENPAAEASG---------GVGPPVFRKELKRLQHSL-SGNTVNLACPVYGK--ANITWTKDKK 431
            |.:..::.:||         ...|....|:|    |:: :||||...||..|.  ..|.|.|:.:
  Rat   125 DPKTLSSSSSGHSYLQQAPYWTHPQRMEKKL----HAVPAGNTVKFRCPAAGNPMPTIHWLKNGQ 185

  Fly   432 PL---NRELGVYVQ-KNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIV-- 490
            ..   ||..|:.:: ::|:|........|.|.|.|.|.|:.|.|::.:.:.:.:|:...||:.
  Rat   186 AFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAG 250

  Fly   491 VPQNQTVKVNGSLVMKCTVYSDLHPTVSW-KRVVLKNASL--DGLKSVEIQNLNFTVTNDSVVLT 552
            :|.|.|..|..::.:.|.||||..|.:.| |.:|:..:|.  ||...|::.......:::..||.
  Rat   251 LPANTTAVVGSNVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTTDINSSEVEVLY 315

  Fly   553 LRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAA----ITIVAL 613
            ||||:.:..|.|||||.:.:|.|..|.:|.|   ||..|      ...|.:|.|.    .|.:.|
  Rat   316 LRNVSAEDAGEYTCLAGNSIGLSYQSAWLTV---LPEAE------EEDLAWTTATSEARYTDIIL 371

  Fly   614 FLLGSAFITFMLRRLRREKLLK--LRIETVH----------QWTKKVIIYRPGGEEGSGCSSGDL 666
            ::.||..:..:|       ||.  ...:.:|          |...:..:.|....|..  |||..
  Rat   372 YVSGSLALVLLL-------LLAGVYHRQAIHGHHSRQPVTVQKLSRFPLARQFSLESR--SSGKS 427

  Fly   667 QMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEA 731
            .:.::|..:       ..:.|.....|....:.|||..||.||.:|.||..||||.||:||.|||
  Rat   428 SLSLVRGVR-------LSSSGPPLLTGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEA 485

  Fly   732 EGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVE 796
            .|:..|.....:.|||||:|:..:|.|:|.|:.|||:||:||:|.|||||||.|:|.|||:||||
  Rat   486 LGMDSSRPDQTSTVAVKMLKDNASDKDLADLISEMEMMKLIGRHKNIINLLGVCTQEGPLYVIVE 550

  Fly   797 YAPHGNLKDFLKQNRPGAPQRRSD----SDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLAS 857
            ||..|||::||:..||..|....|    |:|.|....|:|.           |:|:||||:||.|
  Rat   551 YAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSC-----------AYQVARGMQYLES 604

  Fly   858 RRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQS 922
            |:|||||||||||||::..|||||||||||.:...:||:|.:|||||:||||||:|.::.|..||
  Rat   605 RKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQS 669

  Fly   923 DVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARP 987
            ||||:|:|||||.|.|..|||.| ..|||:|.|..|.|||:|..|...:|.:||:|||.....||
  Rat   670 DVWSFGILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRP 733

  Fly   988 TFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDED---DGSDTETFRETSPL 1043
            ||.:|||:.|.:|...|    :.||||.:......|::||..   ..||:....:..||
  Rat   734 TFKQLVEALDKVLLAVS----EEYLDLRLTFGPYSPNNGDASSTCSSSDSVFSHDPLPL 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	8/21 (38%)
		Ig	258..340	CDD:143165	8/25 (32%)
		I-set	394..479	CDD:254352	26/91 (29%)
		IGc2	408..469	CDD:197706	21/66 (32%)
		IG_like	492..583	CDD:214653	33/93 (35%)
		Ig	507..583	CDD:299845	29/78 (37%)
		PKc_like	700..1000	CDD:304357	166/303 (55%)
		TyrKc	712..996	CDD:197581	158/287 (55%)
Fgfr4	XP_006253668.1	IG	40..108	CDD:214652	10/42 (24%)
		IGc2	47..104	CDD:197706	8/20 (40%)
		Ig	153..237	CDD:299845	26/87 (30%)
		IG_like	158..237	CDD:214653	23/78 (29%)
		IG_like	252..346	CDD:214653	33/93 (35%)
		Ig3_FGFR-2	260..347	CDD:143266	30/89 (34%)
		PKc_like	453..766	CDD:304357	172/328 (52%)
		Pkinase_Tyr	466..742	CDD:285015	158/287 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1150
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1477
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm9075
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.730