DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Fgfr2

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_036844.1	Gene:	Fgfr2 / 25022	RGDID:	2611	Length:	841	Species:	Rattus norvegicus

Alignment Length:	889	Identity:	316/889 - (35%)
Similarity:	452/889 - (50%)	Gaps:	130/889 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 ISWLHNDTQILGGRGRIKLKRWSLTVGQ---LQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKH 237
            :||......:|.....:.|.|.|.::.:   |:||:.                 ||:.::
  Rat    21 VSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEEP-----------------PTKYQI----- 63

  Fly   238 TVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITW----LHKGNADNIDDLLQRLREQSQLP 298
                   ..|....:|.|:::.:.|:|:|:|:   |:|    :|.|                  |
  Rat    64 -------SQPEACVVAPGESLELRCMLKDAAV---ISWTKDGVHLG------------------P 100

  Fly   299 VDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTV 363
            .:.|.||     .:.|::......|.|.|.|.|    .|||         .|:|.......|..:
  Rat   101 NNRTVLI-----GEYLQIKGATPRDSGLYACAA----ARTV---------DSETLYFMVNVTDAI 147

  Fly   364 ASPIPTASTGEDNDDDVENPAAEASGGVGPPVF---RKELKRLQHSLSGNTVNLACPVYGKANIT 425
            :|     ...||:.|..|:..:|.......|.:   .|..|||....:.|||...||..|....|
  Rat   148 SS-----GDDEDDTDSSEDFVSENRSNQRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPTPT 207

  Fly   426 --WTKDKKPLNRE--LGVYVQKN--WTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTR 484
              |.|:.|...:|  :|.|..:|  |:|........|.|.|.|.|.|.:|.|...:.:.:.:|:.
  Rat   208 MRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSP 272

  Fly   485 SAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASL---DGLKSVEIQNLNFTV 544
            ..||:.  :|.|.:..|.|.:...|.||||..|.:.|.:.|.||.|.   |||..:::...:...
  Rat   273 HRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKHSGIN 337

  Fly   545 TNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVV----SPLPPLEIYALLHAHPLGFTL 605
            ::::.||.|.|||....|.|.|..|:.:|::|.|.:|.|:    :|:...||    .|.| .:..
  Rat   338 SSNAEVLALFNVTEMDAGEYICKVSNYIGQANQSAWLTVLPKQQAPVREKEI----TASP-DYLE 397

  Fly   606 AAITIVALFLLGSAFITFMLRRLR--REKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQM 668
            .||..:.:||:....:|.:..|::  .:|........||:.||::.:.|.........||.:...
  Rat   398 IAIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNT 462

  Fly   669 PVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEG 733
            |::||     |...:.|..|....|.:|||.|.|..||.||.:|:||..||||.||:||||||.|
  Rat   463 PLVRI-----TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVG 522

  Fly   734 LPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYA 798
            :.:........|||||:|::.|:.|::.||.|||:|||||||.|||||||.|:|.|||:||||||
  Rat   523 IDKDRPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYA 587

  Fly   799 PHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHR 863
            ..|||:::|:..||...:       |..|...:..:.:..|:|....:|:|||||||||::||||
  Rat   588 SKGNLREYLRARRPPGME-------YSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHR 645

  Fly   864 DLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYG 928
            |||||||||::..|||||||||||||.:.:||:|.||||||:||||||:|.::.|..||||||:|
  Rat   646 DLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFG 710

  Fly   929 VLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELV 993
            ||:|||.|.|..|||.| ..|||:..|..|.||:||..|:..:|::||.|||.....||||.:||
  Rat   711 VLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLV 774

  Fly   994 ESFDGILQQASSNPNDAYLDLSMPMLETPP---------SSGDE 1028
            |..|.||   :...|:.||||:.|:.:..|         ||||:
  Rat   775 EDLDRIL---TLTTNEEYLDLTQPLEQYSPSYPDTRSSCSSGDD 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	11/58 (19%)
		IGc2	157..215	CDD:197706	9/41 (22%)
		IG	247..336	CDD:214652	21/92 (23%)
		Ig	258..340	CDD:143165	20/85 (24%)
		I-set	394..479	CDD:254352	29/93 (31%)
		IGc2	408..469	CDD:197706	22/66 (33%)
		IG_like	492..583	CDD:214653	32/93 (34%)
		Ig	507..583	CDD:299845	28/78 (36%)
		PKc_like	700..1000	CDD:304357	165/299 (55%)
		TyrKc	712..996	CDD:197581	158/283 (56%)
Fgfr2	NP_036844.1	Ig	50..143	CDD:416386	31/160 (19%)
		Ig strand A	50..53	CDD:409353	0/2 (0%)
		Ig strand A'	66..72	CDD:409353	1/5 (20%)
		Ig strand B	75..85	CDD:409353	2/9 (22%)
		Ig strand C	88..93	CDD:409353	2/7 (29%)
		Ig strand C'	96..98	CDD:409353	0/1 (0%)
		Ig strand D	103..107	CDD:409353	1/3 (33%)
		Ig strand E	110..115	CDD:409353	1/4 (25%)
		Ig strand F	121..130	CDD:409353	4/12 (33%)
		Ig strand G	133..143	CDD:409353	2/9 (22%)
		IgI_2_FGFR	173..267	CDD:409443	29/93 (31%)
		Ig strand B	194..198	CDD:409443	1/3 (33%)
		Ig strand C	207..211	CDD:409443	1/3 (33%)
		Ig strand E	233..237	CDD:409443	2/3 (67%)
		Ig strand F	247..252	CDD:409443	2/4 (50%)
		Ig strand G	260..263	CDD:409443	0/2 (0%)
		Ig	275..377	CDD:416386	34/101 (34%)
		Ig strand A	275..278	CDD:409353	2/2 (100%)
		Ig strand A'	282..286	CDD:409353	2/3 (67%)
		Ig strand B	294..301	CDD:409353	2/6 (33%)
		Ig strand C	305..312	CDD:409353	2/6 (33%)
		Ig strand D	327..332	CDD:409353	0/4 (0%)
		Ig strand E	342..347	CDD:409353	2/4 (50%)
		Ig strand F	355..363	CDD:409353	3/7 (43%)
		Ig strand G	366..374	CDD:409353	3/7 (43%)
		FGFR3_TM	391..421	CDD:407957	8/30 (27%)
		PTKc_FGFR2	476..788	CDD:270679	173/322 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1150
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22566
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1477
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm9075
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.730