DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment btl and Ret

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_036775.2	Gene:	Ret / 24716	RGDID:	3556	Length:	1115	Species:	Rattus norvegicus

Alignment Length:	378	Identity:	160/378 - (42%)
Similarity:	223/378 - (58%)	Gaps:	49/378 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   690 PAQGF-----------------------NEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEA 731
            |||||                       :.::.|.|..||.||:.|.||..||||.||:||.|.|
  Rat   680 PAQGFPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPKWEFPRKNLVLGKTLGEGEFGKVVKATA 744

  Fly   732 EGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVE 796
            ..|  ..:...|.|||||:||..:.:::..|:.|..::|.: .|.::|.|.|.|||.|||.:|||
  Rat   745 FRL--KGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQV-NHPHVIKLYGACSQDGPLLLIVE 806

  Fly   797 YAPHGNLKDFLKQNRPGAP-------QRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEY 854
            ||.:|:|:.||:.:|...|       .|.|.|..:.|::.|.    :|  :|..||:||:|||:|
  Rat   807 YAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHPDERVLT----MG--DLISFAWQISRGMQY 865

  Fly   855 LASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYD 919
            ||..:.:||||||||:||::|..|||:||||:||:.:.:.|.|.:.||:|:||||.|||.:..|.
  Rat   866 LAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKWMAIESLFDHIYT 930

  Fly   920 SQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESC 984
            :||||||:|||||||:|.|..|||.| ..|.|::.|.||.|||:|..||..:|.:|.|||..|..
  Rat   931 TQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD 994

  Fly   985 ARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDEDDG-SDTET 1036
            .||.||::.:..:.::.::..     ||||:   ..||..|...||| |:.||
  Rat   995 KRPVFADISKDLEKMMVKSRD-----YLDLA---ASTPSDSLLYDDGLSEEET 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653
		Ig	507..583	CDD:299845
		PKc_like	700..1000	CDD:304357	142/306 (46%)
		TyrKc	712..996	CDD:197581	136/290 (47%)
Ret	NP_036775.2	Cadherin	173..248	CDD:278457
		PTKc_RET	724..1013	CDD:173631	136/298 (46%)
		Pkinase_Tyr	725..1006	CDD:285015	136/290 (47%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810