DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Pdgfrb

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_113713.1	Gene:	Pdgfrb / 24629	RGDID:	3285	Length:	1097	Species:	Rattus norvegicus

Alignment Length:	1166	Identity:	297/1166 - (25%)
Similarity:	455/1166 - (39%)	Gaps:	371/1166 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 ATLLRLERAQSGNSGNYGCLDSQNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQPL 136
            :::|.|.....|::|.|.|:      ||.||  |.:......|..||        |:..:.|.|:
  Rat    81 SSVLTLTNVTGGDTGEYFCV------YNNSL--GPELSERKRIYIFV--------PDPTMGFLPM 129

  Fly   137 NESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPD------AKGVNISWLH--NDTQILGGRGRIK 193
            :.......:..:.:|.         :.|...||.      .|.|:|. ||  .|.|    ||
  Rat   130 DSEDLFIFVTDVTETT---------IPCRVTDPQLEVTLHEKKVDIP-LHVPYDHQ----RG--- 177

  Fly   194 LKRWSLTVGQLQPEDAGSYHCELCV---EQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALG 255
                  .:|..:.:   :|.|:..:   |.|........|:|.|...:|..::      |.:..|
  Rat   178 ------FIGTFEDK---TYICKTTIGDREVDSDTYYVYSLQVSSINVSVNAVQ------TVVRQG 227

  Fly   256 DNVSIECLLEDSALEPKITWLHKGN-ADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNV 319
            ::::|.|::             .|| ..|......|:: ..:|...||..:..:..    |:|::
  Rat   228 ESITIRCIV-------------MGNDVVNFQWTYPRMK-SGRLVEPVTDYLFGVPS----RIGSI 274

  Fly   320 L------MEDGGWYIC---IAENQVG-------RTVAASYVDLYSPSDTTTV----RTTTTTTVA 364
            |      :.|.|.|.|   ::.|..|       ..:...||.|....:...:    |:.|...|.
  Rat   275 LHIPTAELSDSGTYTCNVSVSVNDHGDEKAINVTVIENGYVRLLETLEDVQIAELHRSRTLQVVF 339

  Fly   365 SPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPVYGKANITWTKD 429
            ...||.|.                      ::.|:.:.|..|.:|..      |....|::.|:
  Rat   340 EAYPTPSV----------------------LWFKDNRTLGDSSAGEL------VLSTRNVSETR- 375

  Fly   430 KKPLNRELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQN 494
                      ||.:   |..|.....::|.|..:..:|...:|..|.:|:|     .|:.|:..:
  Rat   376 ----------YVSE---LTLVRVKVSEAGYYTMRAFHADDQVQLSFKLQVN-----VPVRVLELS 422

  Fly   495 QTVKVNGSLVMKCTVYSDLHPTVSW------KRVVLKNASLD-GLKSVEIQNLNFTVT------N 546
            ::...||..:::|.......|.|:|      ||...|.:... |..|.|...|...||      .
  Rat   423 ESHPANGEQILRCRGRGMPQPNVTWSTCRDLKRCPRKLSPTPLGNSSKEESQLETNVTFWEEDQE 487

  Fly   547 DSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVS-PLPPLEIYALLHAHPLGFTLAAITI 610
            ..||.|||....||.....|:..:.:||.:..|.:...| |...:.|.|:|       .|..:|:
  Rat   488 YEVVSTLRLRHVDQPLSVRCMLQNSMGRDSQEVTVVPHSLPFKVVVISAIL-------ALVVLTV 545

  Fly   611 VALFLLGSAFITFMLRRLRREKLLKLRIETV----HQWTKKVIIYRPGGEEGSGCSSGDLQMPVI 671
            ::|.:|    |....|:.|.|...|: ||:|    |::     ||
  Rat   546 ISLIIL----IMLWQRKPRYEIRWKV-IESVSSDGHEY-----IY-------------------- 580

  Fly   672 RIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPR 736
                            .||.|      .|.||.||:||.||.||..||.||||:||.|.|.||..
  Rat   581 ----------------VDPVQ------LPYDSTWELPRDQLVLGRTLGSGAFGQVVEATAHGLSH 623

  Fly   737 SPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHG 801
            |.  |...|||||:|.....::..:|:.|:::|..:|.|:|::||||.|::|||:::|.||..:|
  Rat   624 SQ--ATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIYIITEYCRYG 686

  Fly   802 NLKDFLKQNRPGAPQRRS-----------------------------DSD-GYLD---------- 826
            :|.|:|.:|:....||.|                             :|| ||:|
  Rat   687 DLVDYLHRNKHTFLQRHSNKHCPPSTELYSNALPVGLSLPSHLNLTGESDGGYMDMSKDESVDYV 751

  Fly   827 -----------------------------------------DKPLISTQHLGEKELTKFAFQIAR 850
                                                     |.|::|     ..:|..|::|:|.
  Rat   752 PMLDMKGHIKYADIESSSYMAPYDNYVPSAPERTYRATLINDSPVLS-----YTDLVGFSYQVAN 811

  Fly   851 GMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDI-QDTEYYRKNTNGRLPIKWMAPESLQ 914
            |||:|||:.|:||||||||||:.:|.::||.|||||||| :|:.|..|.:. .||:|||||||:.
  Rat   812 GMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGST-FLPLKWMAPESIF 875

  Fly   915 EKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCW 979
            ...|.:.|||||:|:|||||.|.|..|||.:...::.|:.:..|.||.:||..|..||.:|::||
  Rat   876 NSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDEIYEIMQKCW 940

  Fly   980 HFESCARPTFAELV--------ESFDGILQQASS------------------------------- 1005
            ..:...||.|::||        |.:....||...
  Rat   941 EEKFETRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARLPGLHSLRSPLDTSS 1005

  Fly  1006 ------NPNDAYLDLSMPMLETPPSSGDED--DGSD---TETFRET---------SPLRYQ 1046
                  .||:...|..:|:.:..|.:.||.  :||.   :.|..|.         |||..|
  Rat  1006 VLYTAVQPNETDNDYIIPLPDPKPDAADEGLLEGSPSLASSTLNEVNTSSTISCDSPLELQ 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	19/93 (20%)
		IGc2	157..215	CDD:197706	14/65 (22%)
		IG	247..336	CDD:214652	19/98 (19%)
		Ig	258..340	CDD:143165	18/98 (18%)
		I-set	394..479	CDD:254352	16/84 (19%)
		IGc2	408..469	CDD:197706	11/60 (18%)
		IG_like	492..583	CDD:214653	26/103 (25%)
		Ig	507..583	CDD:299845	24/88 (27%)
		PKc_like	700..1000	CDD:304357	143/389 (37%)
		TyrKc	712..996	CDD:197581	135/373 (36%)
Pdgfrb	NP_113713.1	ig	36..113	CDD:395002	11/39 (28%)
		Ig strand B	49..53	CDD:409353
		Ig strand C	59..62	CDD:409353
		Ig strand E	82..86	CDD:409353	1/3 (33%)
		Ig strand F	96..101	CDD:409353	2/10 (20%)
		Ig	211..309	CDD:416386	22/121 (18%)
		Ig strand A	211..215	CDD:409353	1/3 (33%)
		Ig strand A'	222..226	CDD:409353	1/3 (33%)
		Ig strand B	228..237	CDD:409353	2/21 (10%)
		Ig strand C	242..247	CDD:409353	1/4 (25%)
		Ig strand C'	250..252	CDD:409353	1/1 (100%)
		Ig strand D	256..264	CDD:409353	3/7 (43%)
		Ig strand E	270..277	CDD:409353	3/6 (50%)
		Ig strand F	287..293	CDD:409353	2/5 (40%)
		Ig strand G	298..304	CDD:409353	1/5 (20%)
		Ig	313..414	CDD:416386	27/147 (18%)
		PKc_like	561..952	CDD:419665	151/446 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1016..1097		13/51 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910