DRSC/TRiP Functional Genomics Resources

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Protein Alignment btl and FGFR4

DIOPT Version :9

Sequence 1:NP_001014583.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_001341913.1 Gene:FGFR4 / 2264 HGNCID:3691 Length:802 Species:Homo sapiens


Alignment Length:857 Identity:308/857 - (35%)
Similarity:423/857 - (49%) Gaps:132/857 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 LEVISRKHTVPMLKPG---YPRNTSIALGDNVSIECLLEDSALEPKITWLHKGN----ADNIDDL 287
            ||........|.|.|.   ..:..::|||..|.:.|    ...|....|..:|:    |..:...
Human    22 LEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCC----GRAERGGHWYKEGSRLAPAGRVRGW 82

  Fly   288 LQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDT 352
            ..||...|.||                       ||.|.|:|:|...:                 
Human    83 RGRLEIASFLP-----------------------EDAGRYLCLARGSM----------------- 107

  Fly   353 TTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVF----RKELKRLQHSLSGNTVN 413
              :.....|.:.....|:|..:::.....:|:...|.....|.:    |.| |:|....:||||.
Human   108 --IVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRME-KKLHAVPAGNTVK 169

  Fly   414 LACPVYGK--ANITWTKDKKPL---NRELGVYVQ-KNWTLRFVEATSEDSGLYNCKVCNAWGCIQ 472
            ..||..|.  ..|.|.||.:..   ||..|:.:: ::|:|........|.|.|.|.|.||.|.|:
Human   170 FRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIR 234

  Fly   473 FDFSVQINDRTRSAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSW-KRVVLKNASL--DGL 532
            :::.:.:.:|:...||:.  :|.|.|..|...:.:.|.||||..|.:.| |.:|:..:|.  ||.
Human   235 YNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGF 299

  Fly   533 KSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLH 597
            ..|::.......:::..||.||||:.:..|.|||||.:.:|.|..|.:|.|:....|.       
Human   300 PYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPT------- 357

  Fly   598 AHPLGFTLAA----ITIVALFLLGS--AFITFMLRRLRREKLLKLR----IETVHQWTKKVIIYR 652
                 :|.||    .|.:.|:..||  ..:..:|..|.|.:.|..|    ..||.:.::..:..:
Human   358 -----WTAAAPEARYTDIILYASGSLALAVLLLLAGLYRGQALHGRHPRPPATVQKLSRFPLARQ 417

  Fly   653 PGGEEG-SGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPA--QGFNEYEFPLDSNWEIPRQQLSL 714
            ...|.| ||.||..|...|        .:|::|     ||  .|....:.|||..||.||.:|.|
Human   418 FSLESGSSGKSSSSLVRGV--------RLSSSG-----PALLAGLVSLDLPLDPLWEFPRDRLVL 469

  Fly   715 GSILGEGAFGRVVMAEAEGL-PRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINI 778
            |..||||.||:||.|||.|: |..|..|.| |||||:|:..:|.|:|.||.||||||:||:|.||
Human   470 GKPLGEGCFGQVVRAEAFGMDPARPDQAST-VAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNI 533

  Fly   779 INLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSD----SDGYLDDKPLISTQHLGEK 839
            |||||.|:|.|||:||||.|..|||::||:..||..|....|    |:|.|....|:|.      
Human   534 INLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC------ 592

  Fly   840 ELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLP 904
                 |:|:||||:||.||:|||||||||||||::..|||||||||||.:...:||:|.:|||||
Human   593 -----AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 652

  Fly   905 IKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSL 969
            :||||||:|.::.|..||||||:|:|||||.|.|..|||.| ..|||:|.|..|.||::|..|..
Human   653 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMDRPPHCPP 716

  Fly   970 NIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDED---DG 1031
            .:|.:||:|||.....||||.:|||:.|.:|...|    :.||||.:......||.||..   ..
Human   717 ELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS----EEYLDLRLTFGPYSPSGGDASSTCSS 777

  Fly  1032 SDTETFRETSPL 1043
            ||:....:..||
Human   778 SDSVFSHDPLPL 789

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btlNP_001014583.1 IG_like 149..232 CDD:214653 1/1 (100%)
IGc2 157..215 CDD:197706
IG 247..336 CDD:214652 20/92 (22%)
Ig 258..340 CDD:143165 17/85 (20%)
I-set 394..479 CDD:254352 30/94 (32%)
IGc2 408..469 CDD:197706 23/66 (35%)
IG_like 492..583 CDD:214653 33/93 (35%)
Ig 507..583 CDD:299845 29/78 (37%)
PKc_like 700..1000 CDD:304357 169/304 (56%)
TyrKc 712..996 CDD:197581 161/288 (56%)
FGFR4NP_001341913.1 IGc2 50..107 CDD:197706 18/83 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 119..148 4/28 (14%)
Ig 157..241 CDD:325142 27/83 (33%)
Ig3_FGFR-2 264..351 CDD:143266 29/86 (34%)
PKc_like 454..767 CDD:328722 175/329 (53%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 325 1.000 Domainoid score I1191
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 478 1.000 Inparanoid score I1485
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D119660at33208
OrthoFinder 1 1.000 - - FOG0000923
OrthoInspector 1 1.000 - - mtm8598
orthoMCL 1 0.900 - - OOG6_100013
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R6544
SonicParanoid 1 1.000 - - X537
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1211.760

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