DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment btl and FGFR3

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_006713931.1	Gene:	FGFR3 / 2261	HGNCID:	3690	Length:	811	Species:	Homo sapiens

Alignment Length:	842	Identity:	307/842 - (36%)
Similarity:	434/842 - (51%)	Gaps:	116/842 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 TQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLR 292
            |:..|:.|...||..:||.........||.|.:.|............|:..|..
Human    27 TEQRVVGRAAEVPGPEPGQQEQLVFGSGDAVELSCPPPGGGPMGPTVWVKDGTG----------- 80

  Fly   293 EQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRT 357
                 .|...|::.   .||.|::.|...||.|.|.|  ..::.:.|...:          :||.
Human    81 -----LVPSERVLV---GPQRLQVLNASHEDSGAYSC--RQRLTQRVLCHF----------SVRV 125

  Fly   358 TTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSL----SGNTVNLACPV 418
            |..       |::...||.:|:.|:...:    .|.|.:.:. :|:...|    :.|||...||.
Human   126 TDA-------PSSGDDEDGEDEAEDTGVD----TGAPYWTRP-ERMDKKLLAVPAANTVRFRCPA 178

  Fly   419 YGK--ANITWTKDKKPLNREL---GVYVQ-KNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSV 477
            .|.  .:|:|.|:.:....|.   |:.:: :.|:|........|.|.|.|.|.|.:|.|:..:::
Human   179 AGNPTPSISWLKNGREFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQTYTL 243

  Fly   478 QINDRTRSAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASL---DGLKSVEI 537
            .:.:|:...||:.  :|.|||..:...:...|.||||..|.:.|.:.|..|.|.   ||...|.:
Human   244 DVLERSPHRPILQAGLPANQTAVLGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTPYVTV 308

  Fly   538 QN--LNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLE--------- 591
            ..  ::.:|..| |.|.|.||:....|.|.|.|::.:|.:..:.:|.|..|....|
Human   309 LKSWISESVEAD-VRLRLANVSERDGGEYLCRATNFIGVAEKAFWLSVHGPRAAEEELVEADEAG 372

  Fly   592 -IYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWT-----KKVII 650
             :||.:.::.:||        .||:|..|.:|  |.|||......|...|||:.:     ::|.:
Human   373 SVYAGILSYGVGF--------FLFILVVAAVT--LCRLRSPPKKGLGSPTVHKISRFPLKRQVTV 427

  Fly   651 YRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLG 715
               ..|..:..||   ..|::||.:     .::|.|.|  ....:|.|.|.|..||:.|.:|:||
Human   428 ---SLESNASMSS---NTPLVRIAR-----LSSGEGPT--LANVSELELPADPKWELSRARLTLG 479

  Fly   716 SILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIIN 780
            ..||||.||:||||||.|:.:........|||||:|::.||.|::.||.|||:|||||||.||||
Human   480 KPLGEGCFGQVVMAEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIIN 544

  Fly   781 LLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFA 845
            |||.|:|||||:|:||||..|||::||:..||.......|:     .||  ..:.|..|:|...|
Human   545 LLGACTQGGPLYVLVEYAAKGNLREFLRARRPPGLDYSFDT-----CKP--PEEQLTFKDLVSCA 602

  Fly   846 FQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAP 910
            :|:|||||||||::|||||||||||||::..||||||||||||:.:.:||:|.||||||:|||||
Human   603 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAP 667

  Fly   911 ESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVM 975
            |:|.::.|..||||||:|||||||.|.|..|||.| ..|||:..|..|.||:|||.|:.::|::|
Human   668 EALFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPANCTHDLYMIM 731

  Fly   976 RQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPM-------LETPPSSGDEDD 1030
            |:|||.....||||.:|||..|.:|...|:  :..|||||.|.       .:||.||...||
Human   732 RECWHAAPSQRPTFKQLVEDLDRVLTVTST--DQEYLDLSAPFEQYSPGGQDTPSSSSSGDD 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	1/3 (33%)
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	17/88 (19%)
		Ig	258..340	CDD:143165	15/81 (19%)
		I-set	394..479	CDD:254352	24/94 (26%)
		IGc2	408..469	CDD:197706	19/66 (29%)
		IG_like	492..583	CDD:214653	30/95 (32%)
		Ig	507..583	CDD:299845	26/80 (33%)
		PKc_like	700..1000	CDD:304357	170/299 (57%)
		TyrKc	712..996	CDD:197581	164/283 (58%)
FGFR3	XP_006713931.1	IGc2	53..110	CDD:197706	17/77 (22%)
		IG	54..125	CDD:214652	19/101 (19%)
		Ig2_FGFR	161..245	CDD:143265	22/83 (27%)
		IG_like	171..245	CDD:214653	20/73 (27%)
		IG_like	260..355	CDD:214653	30/95 (32%)
		Ig3_FGFR	268..356	CDD:143175	26/88 (30%)
		PKc_like	463..797	CDD:304357	184/339 (54%)
		Pkinase_Tyr	476..752	CDD:285015	164/283 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1191
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1485
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8598
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760