DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and FGFR1

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_011542745.1	Gene:	FGFR1 / 2260	HGNCID:	3688	Length:	865	Species:	Homo sapiens

Alignment Length:	875	Identity:	309/875 - (35%)
Similarity:	434/875 - (49%)	Gaps:	142/875 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 RIKLK-RWSLTV------GQLQPED-----AGSYHC----------ELCVEQDCQRSNPTQLEVI 233
            |:.|| |..|||      |.|.|..     ..|:.|          .||.    .|.:||..|
Human     4 RVSLKRRIELTVEYPWRCGALSPTSNCRTGMWSWKCLLFWAVLVTATLCT----ARPSPTLPE-- 62

  Fly   234 SRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLP 298
               ...|...|....:..:..||.:.:.|.|.|..  ..|.||..|         .:|.|.::
Human    63 ---QAQPWGAPVEVESFLVHPGDLLQLRCRLRDDV--QSINWLRDG---------VQLAESNR-- 111

  Fly   299 VDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTV 363
                   ||:...:| .:.:.:..|.|.|.|:..:..|             ||||..    :..|
Human   112 -------TRITGEEV-EVQDSVPADSGLYACVTSSPSG-------------SDTTYF----SVNV 151

  Fly   364 ASPIPTASTGEDNDDDVENPAAE-------------ASGGVGPPVFRKELKRLQHSL-SGNTVNL 414
            :..:|::   ||:|||.::.:.|             |.....|....|:|    |:: :..||..
Human   152 SDALPSS---EDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKL----HAVPAAKTVKF 209

  Fly   415 ACPVYGKANIT--WTKDKKPL--NRELGVYVQK--NWTLRFVEATSEDSGLYNCKVCNAWGCIQF 473
            .||..|..|.|  |.|:.|..  :..:|.|..:  .|::........|.|.|.|.|.|.:|.|..
Human   210 KCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINH 274

  Fly   474 DFSVQINDRTRSAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASL---DGLK 533
            .:.:.:.:|:...||:.  :|.|:||.:..::...|.||||..|.:.|.:.:..|.|.   |.|.
Human   275 TYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLP 339

  Fly   534 SVEI---QNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYAL 595
            .|:|   ..:| |...:..||.||||:|:..|.|||||.:.:|.|:.|.:|.|:.         .
Human   340 YVQILKTAGVN-TTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLE---------A 394

  Fly   596 LHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIET----------VHQWTKKVII 650
            |...|...|......:.::..|:..|:.|:..:   .:.|::..|          ||:..|.:.:
Human   395 LEERPAVMTSPLYLEIIIYCTGAFLISCMVGSV---IVYKMKSGTKKSDFHSQMAVHKLAKSIPL 456

  Fly   651 YRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLG 715
            .|.  ...|..||..:...|:.:...|.:.|     ||....|.:|||.|.|..||:||.:|.||
Human   457 RRQ--VTVSADSSASMNSGVLLVRPSRLSSS-----GTPMLAGVSEYELPEDPRWELPRDRLVLG 514

  Fly   716 SILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIIN 780
            ..||||.||:||:|||.||.:......|.|||||:|.:.|:.|::.|:.|||:|||||||.||||
Human   515 KPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIIN 579

  Fly   781 LLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFA 845
            |||.|:|.|||:||||||..|||:::|:..||...:       |..:......:.|..|:|...|
Human   580 LLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLE-------YCYNPSHNPEEQLSSKDLVSCA 637

  Fly   846 FQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAP 910
            :|:|||||||||::|||||||||||||::..|||||||||||||...:||:|.||||||:|||||
Human   638 YQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAP 702

  Fly   911 ESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVM 975
            |:|.::.|..||||||:|||||||.|.|..|||.: ..|||:..|..|.||:||:.|:..:|::|
Human   703 EALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMM 766

  Fly   976 RQCWHFESCARPTFAELVESFDGILQQASS 1005
            |.|||.....||||.:|||..|.|:...|:
Human   767 RDCWHAVPSQRPTFKQLVEDLDRIVALTSN 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	17/62 (27%)
		IGc2	157..215	CDD:197706	12/45 (27%)
		IG	247..336	CDD:214652	18/88 (20%)
		Ig	258..340	CDD:143165	17/81 (21%)
		I-set	394..479	CDD:254352	24/91 (26%)
		IGc2	408..469	CDD:197706	19/66 (29%)
		IG_like	492..583	CDD:214653	36/96 (38%)
		Ig	507..583	CDD:299845	32/81 (40%)
		PKc_like	700..1000	CDD:304357	166/299 (56%)
		TyrKc	712..996	CDD:197581	159/283 (56%)
FGFR1	XP_011542745.1	Ig1_FGFR	73..151	CDD:143174	23/115 (20%)
		IG_like	77..151	CDD:214653	23/111 (21%)
		I-set	193..280	CDD:254352	24/90 (27%)
		Ig2_FGFR	196..280	CDD:143265	24/87 (28%)
		IG_like	295..391	CDD:214653	36/96 (38%)
		Ig3_FGFR	303..392	CDD:143175	32/89 (36%)
		PTKc_FGFR1	497..797	CDD:270678	169/308 (55%)
		Pkinase_Tyr	511..787	CDD:285015	159/283 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1191
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	478	1.000	Inparanoid score	I1485
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8598
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.760