DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment btl and Ret

DIOPT Version :10

Sequence 1:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_033076.2 Gene:Ret / 19713 MGIID:97902 Length:1115 Species:Mus musculus


Alignment Length:995 Identity:262/995 - (26%)
Similarity:396/995 - (39%) Gaps:295/995 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 SLVVGHKEPVGNDIASFVKLEDAPALPES--------------DLFFQP---LNESRSLKLLQPL 148
            |.||..|...|..:|: :::.||..:|.|              |.:.|.   :..|....|:|..
Mouse   281 SAVVEFKRKEGTVVAT-LQVFDADVVPASGELVRRYTNTLLSGDSWAQQTFRVEHSPIETLVQVN 344

  Fly   149 PKTVQRTAGGL-FQLNCSPMDPDAKGVNISWLHNDTQILG-GRGRIKLKRWSLTVGQLQPEDAGS 211
            ..:|:.|.... ..||.|....:::.:.::.|.||:...| |.|.|.:..::::|..:......:
Mouse   345 NNSVRATMHNYKLILNRSLSISESRVLQLAVLVNDSDFQGPGAGGILVLHFNVSVLPVTLNLPRA 409

  Fly   212 YHC-------------ELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECL 263
            |..             ::||| :||..:...::.        .|:|.             ||.|.
Mouse   410 YSFPVNKRARRYAQIGKVCVE-NCQEFSGVSIQY--------KLQPS-------------SINCT 452

  Fly   264 LEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYI 328
            .......|:.|                   ...|.|:.|..:.|   |:..:|         .|.
Mouse   453 ALGVVTSPEDT-------------------SGTLFVNDTEALRR---PECTKL---------QYT 486

  Fly   329 CIA-ENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVG 392
            .:| :.|..|...||.|       .|...|:.|..|..|...|.       :...|..|..||:|
Mouse   487 VVATDRQTRRQTQASLV-------VTVEGTSITEEVGCPKSCAV-------NKRRPECEECGGLG 537

  Fly   393 PPVFRKELKRLQHSLSGNTVNLA--------CPVYGKANITWTKDKKPLNRELGVYVQKNWTLRF 449
            .|..|.|.:  |....|.|.|.:        || .|..:...::|                    
Mouse   538 SPTGRCEWR--QGDGKGITRNFSTCSPSTRTCP-DGHCDAVESRD-------------------- 579

  Fly   450 VEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLH 514
                        ..:| ...|::.|.   :....|.       :.|.:|....:   |..:.|  
Mouse   580 ------------ANIC-PQDCLRADI---VGGHERG-------ERQGIKAGYGI---CNCFPD-- 616

  Fly   515 PTVSWKRVVLKNASLDGLKSVEIQNLNFTVTNDS----------VVLTLRNVTFDQEGWYTCLAS 569
                                   :...|....||          .::|                 
Mouse   617 -----------------------EKKCFCEPEDSQGPLCDALCRTIIT----------------- 641

  Fly   570 SGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLL 634
                   ::::..::|.|  |.|:.:.|.|..|....         :.||.:||    .|..:..
Mouse   642 -------AALFSLIISIL--LSIFCVCHHHKHGHKPP---------IASAEMTF----CRPAQGF 684

  Fly   635 KLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEF 699
            .             |.|...|.......|.:.|:||                        :.::.
Mouse   685 P-------------ISYSSSGTRRPSLDSTENQVPV------------------------DSFKI 712

  Fly   700 PLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVR 764
            |.|..||.||:.|.||..||||.||:||.|.|..|  ..:...|.|||||:||..:.:::..|:.
Mouse   713 PEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRL--KGRAGYTTVAVKMLKENASQSELRDLLS 775

  Fly   765 EMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNR-------PGAPQRRSDSD 822
            |..::|.: .|.::|.|.|.|||.|||.:|||||.:|:|:.||:.:|       .|...|.|.|.
Mouse   776 EFNLLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSGGGSRNSSSL 839

  Fly   823 GYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLAR 887
            .:.|::.|.    :|  :|..||:||:|||:|||..:.:||||||||:||::|..|||:||||:|
Mouse   840 DHPDERVLT----MG--DLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR 898

  Fly   888 DIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELY 952
            |:.:.:.|.|.:.||:|:||||.|||.:..|.:||||||:|||||||:|.|..|||.| ..|.|:
Mouse   899 DVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLF 962

  Fly   953 SYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMP 1017
            :.|.||.|||:|..||..:|.:|.|||..|...||.||::.:..:.::.::..     ||||:  
Mouse   963 NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRD-----YLDLA-- 1020

  Fly  1018 MLETPPSSGDEDDG-SDTET 1036
             ..||..|...||| |:.||
Mouse  1021 -ASTPSDSLLYDDGLSEEET 1039

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btlNP_729956.1 Ig 143..215 CDD:472250 16/86 (19%)
Ig strand B 160..164 CDD:409570 1/3 (33%)
Ig strand C 175..179 CDD:409570 0/3 (0%)
Ig strand E 197..201 CDD:409570 0/3 (0%)
Ig strand F 211..215 CDD:409570 1/16 (6%)
Ig_3 247..333 CDD:464046 13/86 (15%)
Ig 398..479 CDD:472250 12/88 (14%)
Ig strand B 412..416 CDD:409393 1/11 (9%)
Ig strand C 423..427 CDD:409393 0/3 (0%)
Ig strand E 445..449 CDD:409393 0/3 (0%)
Ig strand F 459..464 CDD:409393 0/4 (0%)
Ig strand G 472..475 CDD:409393 0/2 (0%)
IG_like 492..583 CDD:214653 8/100 (8%)
Ig strand B 503..507 CDD:409444 0/3 (0%)
Ig strand C 516..520 CDD:409444 0/3 (0%)
Ig strand E 549..553 CDD:409444 0/3 (0%)
Ig strand F 563..568 CDD:409444 0/4 (0%)
Ig strand G 576..579 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 142/306 (46%)
RetNP_033076.2 RET_CLD1 29..154 CDD:465485
Cadherin-like region 1 (CLD1). /evidence=ECO:0000250|UniProtKB:P07949 29..153
Cadherin 173..262 CDD:394985
Cadherin-like region 3 (CLD3). /evidence=ECO:0000250|UniProtKB:P07949 266..380 22/99 (22%)
RET_CLD3 266..380 CDD:465516 22/99 (22%)
Cadherin-like region 4 (CLD4). /evidence=ECO:0000250|UniProtKB:P07949 407..508 27/160 (17%)
RET_CLD4 409..508 CDD:465517 27/158 (17%)
PTKc_RET 724..1013 CDD:173631 136/298 (46%)
Blue background indicates that the domain is not in the aligned region.

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