DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Ret

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_033076.2	Gene:	Ret / 19713	MGIID:	97902	Length:	1115	Species:	Mus musculus

Alignment Length:	995	Identity:	262/995 - (26%)
Similarity:	396/995 - (39%)	Gaps:	295/995 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 SLVVGHKEPVGNDIASFVKLEDAPALPES--------------DLFFQP---LNESRSLKLLQPL 148
            |.||..|...|..:|: :::.||..:|.|              |.:.|.   :..|....|:|..
Mouse   281 SAVVEFKRKEGTVVAT-LQVFDADVVPASGELVRRYTNTLLSGDSWAQQTFRVEHSPIETLVQVN 344

  Fly   149 PKTVQRTAGGL-FQLNCSPMDPDAKGVNISWLHNDTQILG-GRGRIKLKRWSLTVGQLQPEDAGS 211
            ..:|:.|.... ..||.|....:::.:.::.|.||:...| |.|.|.:..::::|..:......:
Mouse   345 NNSVRATMHNYKLILNRSLSISESRVLQLAVLVNDSDFQGPGAGGILVLHFNVSVLPVTLNLPRA 409

  Fly   212 YHC-------------ELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECL 263
            |..             ::||| :||..:...::.        .|:|.             ||.|.
Mouse   410 YSFPVNKRARRYAQIGKVCVE-NCQEFSGVSIQY--------KLQPS-------------SINCT 452

  Fly   264 LEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYI 328
            .......|:.|                   ...|.|:.|..:.|   |:..:|         .|.
Mouse   453 ALGVVTSPEDT-------------------SGTLFVNDTEALRR---PECTKL---------QYT 486

  Fly   329 CIA-ENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVG 392
            .:| :.|..|...||.|       .|...|:.|..|..|...|.       :...|..|..||:|
Mouse   487 VVATDRQTRRQTQASLV-------VTVEGTSITEEVGCPKSCAV-------NKRRPECEECGGLG 537

  Fly   393 PPVFRKELKRLQHSLSGNTVNLA--------CPVYGKANITWTKDKKPLNRELGVYVQKNWTLRF 449
            .|..|.|.:  |....|.|.|.:        || .|..:...::|
Mouse   538 SPTGRCEWR--QGDGKGITRNFSTCSPSTRTCP-DGHCDAVESRD-------------------- 579

  Fly   450 VEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLH 514
                        ..:| ...|::.|.   :....|.       :.|.:|....:   |..:.|
Mouse   580 ------------ANIC-PQDCLRADI---VGGHERG-------ERQGIKAGYGI---CNCFPD-- 616

  Fly   515 PTVSWKRVVLKNASLDGLKSVEIQNLNFTVTNDS----------VVLTLRNVTFDQEGWYTCLAS 569
                                   :...|....||          .::|
Mouse   617 -----------------------EKKCFCEPEDSQGPLCDALCRTIIT----------------- 641

  Fly   570 SGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLL 634
                   ::::..::|.|  |.|:.:.|.|..|....         :.||.:||    .|..:..
Mouse   642 -------AALFSLIISIL--LSIFCVCHHHKHGHKPP---------IASAEMTF----CRPAQGF 684

  Fly   635 KLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEF 699
            .             |.|...|.......|.:.|:||                        :.::.
Mouse   685 P-------------ISYSSSGTRRPSLDSTENQVPV------------------------DSFKI 712

  Fly   700 PLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVR 764
            |.|..||.||:.|.||..||||.||:||.|.|..|  ..:...|.|||||:||..:.:::..|:.
Mouse   713 PEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFRL--KGRAGYTTVAVKMLKENASQSELRDLLS 775

  Fly   765 EMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNR-------PGAPQRRSDSD 822
            |..::|.: .|.::|.|.|.|||.|||.:|||||.:|:|:.||:.:|       .|...|.|.|.
Mouse   776 EFNLLKQV-NHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSGGGSRNSSSL 839

  Fly   823 GYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLAR 887
            .:.|::.|.    :|  :|..||:||:|||:|||..:.:||||||||:||::|..|||:||||:|
Mouse   840 DHPDERVLT----MG--DLISFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSR 898

  Fly   888 DIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELY 952
            |:.:.:.|.|.:.||:|:||||.|||.:..|.:||||||:|||||||:|.|..|||.| ..|.|:
Mouse   899 DVYEEDSYVKKSKGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGI-PPERLF 962

  Fly   953 SYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMP 1017
            :.|.||.|||:|..||..:|.:|.|||..|...||.||::.:..:.::.::..     ||||:
Mouse   963 NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKSRD-----YLDLA-- 1020

  Fly  1018 MLETPPSSGDEDDG-SDTET 1036
             ..||..|...||| |:.||
Mouse  1021 -ASTPSDSLLYDDGLSEEET 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	19/97 (20%)
		IGc2	157..215	CDD:197706	12/72 (17%)
		IG	247..336	CDD:214652	14/89 (16%)
		Ig	258..340	CDD:143165	15/82 (18%)
		I-set	394..479	CDD:254352	14/92 (15%)
		IGc2	408..469	CDD:197706	8/68 (12%)
		IG_like	492..583	CDD:214653	8/100 (8%)
		Ig	507..583	CDD:299845	6/85 (7%)
		PKc_like	700..1000	CDD:304357	142/306 (46%)
		TyrKc	712..996	CDD:197581	136/290 (47%)
Ret	NP_033076.2	Cadherin	173..262	CDD:278457
		PTKc_RET	724..1013	CDD:173631	136/298 (46%)
		Pkinase_Tyr	725..1006	CDD:285015	136/290 (47%)
		Inhibitors binding. /evidence=ECO:0000250	806..808		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810