DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Pdgfrb

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001139740.1	Gene:	Pdgfrb / 18596	MGIID:	97531	Length:	1099	Species:	Mus musculus

Alignment Length:	1175	Identity:	297/1175 - (25%)
Similarity:	447/1175 - (38%)	Gaps:	388/1175 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 ATLLRLERAQSGNSGNYGCLDSQNRWYNISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQPL 136
            :::|.|.....|::|.|.|:      ||.||  |.:......|..||        |:..:.|.|:
Mouse    81 SSVLTLTNVTGGDTGEYFCV------YNNSL--GPELSERKRIYIFV--------PDPTMGFLPM 129

  Fly   137 NESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPD------AKGVNISWLH--NDTQILGGRGRIK 193
            :.......:..:.:|.         :.|...||.      .|.|:|. ||  .|.| .|..|..:
Mouse   130 DSEDLFIFVTDVTETT---------IPCRVTDPQLEVTLHEKKVDIP-LHVPYDHQ-RGFTGTFE 183

  Fly   194 LKRW--SLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGD 256
            .|.:  ..|:|. :..|:.:|:.             ..|:|.|...:|..::      |.:..|:
Mouse   184 DKTYICKTTIGD-REVDSDTYYV-------------YSLQVSSINVSVNAVQ------TVVRQGE 228

  Fly   257 NVSIECLLEDSALEPKITWLHKGN-ADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVL 320
            :::|.|::             .|| ..|......|:: ..:|...||..:..:..    |:|::|
Mouse   229 SITIRCIV-------------MGNDVVNFQWTYPRMK-SGRLVEPVTDYLFGVPS----RIGSIL 275

  Fly   321 ------MEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGED---N 376
                  :.|.|.|.|        .|:.|..|                          .|::   |
Mouse   276 HIPTAELSDSGTYTC--------NVSVSVND--------------------------HGDEKAIN 306

  Fly   377 DDDVEN---PAAEASGGVGPPVFRKELKRLQHSLSGNTVNLACPVYGKANITWTKDKKPLNRELG 438
            ...:||   ...|..|.|       |:..|..|   .|:.:....|...::.|.||    ||.||
Mouse   307 ISVIENGYVRLLETLGDV-------EIAELHRS---RTLRVVFEAYPMPSVLWLKD----NRTLG 357

  Fly   439 -------VYVQKNWT-------LRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPII 489
                   |...:|.:       |..|.....::|.|..:..:....:|..|.:|:|     .|:.
Mouse   358 DSGAGELVLSTRNMSETRYVSELILVRVKVSEAGYYTMRAFHEDDEVQLSFKLQVN-----VPVR 417

  Fly   490 VVPQNQTVKVNGSLVMKCTVYSDLHPTVSW-------KRVVLKNASLD-GLKSVEIQNLNFTVT- 545
            |:..:::...||...::|.......|.|:|       .|...|.:... |..|.|...|...||
Mouse   418 VLELSESHPANGEQTIRCRGRGMPQPNVTWSTCRDLKSRCPRKLSPTPLGNSSKEESQLETNVTF 482

  Fly   546 -----NDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTL 605
                 ...||.|||....||.....|:..:.:|..:..|   .|.|            |.|.|.:
Mouse   483 WEEDQEYEVVSTLRLRHVDQPLSVRCMLQNSMGGDSQEV---TVVP------------HSLPFKV 532

  Fly   606 AAIT-IVALFLLG--SAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQ 667
            ..|: |:||.:|.  |..|..||                  |.||.
Mouse   533 VVISAILALVVLTVISLIILIML------------------WQKKP------------------- 560

  Fly   668 MPVIRIEKQRTTVSTTGTGG-----TDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVV 727
                |.|.:...:.:..:.|     .||.|      .|.||.||:||.||.||..||.||||:||
Mouse   561 ----RYEIRWKVIESVSSDGHEYIYVDPVQ------LPYDSTWELPRDQLVLGRTLGSGAFGQVV 615

  Fly   728 MAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLW 792
            .|.|.||..|.  |...|||||:|.....::..:|:.|:::|..:|.|:|::||||.|::|||::
Mouse   616 EATAHGLSHSQ--ATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTKGGPIY 678

  Fly   793 VIVEYAPHGNLKDFLKQNRPGAPQRRS-----------------------------DSD-GYLD- 826
            :|.||..:|:|.|:|.:|:....||.|                             :|| ||:|
Mouse   679 IITEYCRYGDLVDYLHRNKHTFLQRHSNKHCPPSAELYSNALPVGFSLPSHLNLTGESDGGYMDM 743

  Fly   827 --------------------------------------------------DKPLISTQHLGEKEL 841
                                                              |.|::|     ..:|
Mouse   744 SKDESIDYVPMLDMKGDIKYADIESPSYMAPYDNYVPSAPERTYRATLINDSPVLS-----YTDL 803

  Fly   842 TKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDI-QDTEYYRKNTNGRLPI 905
            ..|::|:|.||::|||:.|:||||||||||:.:|.::||.|||||||| :|:.|..|.:. .||:
Mouse   804 VGFSYQVANGMDFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGST-FLPL 867

  Fly   906 KWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLN 970
            |||||||:....|.:.|||||:|:|||||.|.|..|||.:...::.|:.:..|.||.:||..|..
Mouse   868 KWMAPESIFNSLYTTLSDVWSFGILLWEIFTLGGTPYPELPMNDQFYNAIKRGYRMAQPAHASDE 932

  Fly   971 IYVVMRQCWHFESCARPTFAELV--------ESFDGILQQASS---------------------- 1005
            ||.:|::||..:...||.|::||        |.:....||...
Mouse   933 IYEIMQKCWEEKFETRPPFSQLVLLLERLLGEGYKKKYQQVDEEFLRSDHPAILRSQARFPGIHS 997

  Fly  1006 ---------------NPNDAYLDLSMPMLETPPSSGDE--DDGSD---TETFRET---------S 1041
                           .||::..|..:|:.:..|...||  .:||.   :.|..|.         |
Mouse   998 LRSPLDTSSVLYTAVQPNESDNDYIIPLPDPKPDVADEGLPEGSPSLASSTLNEVNTSSTISCDS 1062

  Fly  1042 PLRYQ 1046
            ||..|
Mouse  1063 PLELQ 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	19/92 (21%)
		IGc2	157..215	CDD:197706	17/67 (25%)
		IG	247..336	CDD:214652	18/95 (19%)
		Ig	258..340	CDD:143165	16/88 (18%)
		I-set	394..479	CDD:254352	20/98 (20%)
		IGc2	408..469	CDD:197706	15/74 (20%)
		IG_like	492..583	CDD:214653	24/104 (23%)
		Ig	507..583	CDD:299845	22/89 (25%)
		PKc_like	700..1000	CDD:304357	142/389 (37%)
		TyrKc	712..996	CDD:197581	134/373 (36%)
Pdgfrb	NP_001139740.1	ig	36..113	CDD:278476	11/39 (28%)
		IG_like	221..309	CDD:214653	23/145 (16%)
		Ig	227..311	CDD:299845	22/135 (16%)
		Ig	313..414	CDD:299845	25/119 (21%)
		IG	334..412	CDD:214652	17/81 (21%)
		PKc_like	562..953	CDD:304357	144/404 (36%)
		Pkinase_Tyr	600..953	CDD:285015	131/360 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1017..1099		13/51 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810