DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Pdgfra

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001076785.1	Gene:	Pdgfra / 18595	MGIID:	97530	Length:	1089	Species:	Mus musculus

Alignment Length:	1083	Identity:	283/1083 - (26%)
Similarity:	439/1083 - (40%)	Gaps:	308/1083 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 TLQCV--------RPMAKWFYED--KFQLRA---------TLLRLERAQSGNSGNYGCLDSQNRW 97
            :|:||        .||::   ||  ..::|:         |:|.:..|.:.::|.|.|      :
Mouse    46 SLRCVGESEVSWQHPMSE---EDDPNVEIRSEENNSGLFVTVLEVVNASAAHTGWYTC------Y 101

  Fly    98 YNISLVVGHKEPVGNDIASFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQL 162
            || .......|..|..|..:|        |:.|:.|.||..:.||.:::.....:         :
Mouse   102 YN-HTQTDESEIEGRHIYIYV--------PDPDMAFVPLGMTDSLVIVEEDDSAI---------I 148

  Fly   163 NCSPMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNP 227
            .|...||:.:..    |||:       ||:....:....|.......|.|.||..|:.  :....
Mouse   149 PCRTTDPETQVT----LHNN-------GRLVPASYDSRQGFNGTFSVGPYICEATVKG--RTFKT 200

  Fly   228 TQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADN--IDDLLQR 290
            ::..|.:.|.|..:......|.|....|:.:.:.|.:.::.: ..:.|.:.|...|  |..|
Mouse   201 SEFNVYALKATSELNLEMDARQTVYKAGETIVVTCAVFNNEV-VDLQWTYPGEVRNKGITML--- 261

  Fly   291 LREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTV 355
              |:.:||  ..:|:..:..|:      ..::|.|.|.|.|...                 |..|
Mouse   262 --EEIKLP--SIKLVYTLTVPK------ATVKDSGEYECAARQA-----------------TKEV 299

  Fly   356 RTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVF-RKELKRLQHSLSGNTVNLACPVY 419
            :.....|:       |..|....::|            |.| :.|...| |.:....|.:  ..|
Mouse   300 KEMKRVTI-------SVHEKGFVEIE------------PTFGQLEAVNL-HEVREFVVEV--QAY 342

  Fly   420 GKANITWTKDKKPLNR---ELGVYVQKNWTLRF------VEATSEDSGLYNCKVCNAWGCIQFDF 475
            ....|:|.||...|..   |:...|||:...|:      :.|..||||.|...|.|......:.|
Mouse   343 PTPRISWLKDNLTLIENLTEITTDVQKSQETRYQSKLKLIRAKEEDSGHYTIIVQNEDDVKSYTF 407

  Fly   476 SVQINDRTRSAPIIVVPQNQTVKVN------GSLVMKCTVYSDLHPTVSW---KRVVLKNASLDG 531
            .:.          .:||.:....|:      |...::||......|.:.|   |.:  |..:.|.
Mouse   408 ELS----------TLVPASILDLVDDHHGSGGGQTVRCTAEGTPLPEIDWMICKHI--KKCNNDT 460

  Fly   532 LKSVEIQNLNFTVTNDSVVLTLR-------NVTF---DQEGWYTCLASSGLGRSNSSVY---LRV 583
            ..:|...|::..:|.    |..|       .|:|   ::.....|||     ::|.||.   |::
Mouse   461 SWTVLASNVSNIITE----LPRRGRSTVEGRVSFAKVEETIAVRCLA-----KNNLSVVARELKL 516

  Fly   584 VSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKV 648
            |:|....|:           |:||..:|.|.::..:.|..                        |
Mouse   517 VAPTLRSEL-----------TVAAAVLVLLVIVIVSLIVL------------------------V 546

  Fly   649 IIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGG-----TDPAQGFNEYEFPLDSNWEIP 708
            :|::              |.|  |.|.:...:.:....|     .||.|      .|.||.||.|
Mouse   547 VIWK--------------QKP--RYEIRWRVIESISPDGHEYIYVDPMQ------LPYDSRWEFP 589

  Fly   709 RQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIG 773
            |..|.||.|||.||||:||...|.||.||..:.:  |||||:|.....::..:|:.|:::|..:|
Mouse   590 RDGLVLGRILGSGAFGKVVEGTAYGLSRSQPVMK--VAVKMLKPTARSSEKQALMSELKIMTHLG 652

  Fly   774 KHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNR-------PGAPQRRSDSDG-------- 823
            .|:||:||||.|::.||:::|.||..:|:|.::|.:||       |..|::..|..|
Mouse   653 PHLNIVNLLGACTKSGPIYIITEYCFYGDLVNYLHKNRDSFMSQHPEKPKKDLDIFGLNPADEST 717

  Fly   824 -------------YLDDKPLISTQH---LGEKELTK----------------------------- 843
                         |:|.|...:||:   |..||::|
Mouse   718 RSYVILSFENNGDYMDMKQADTTQYVPMLERKEVSKYSDIQRSLYDRPASYKKKSMLDSEVKNLL 782

  Fly   844 ---------------FAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDI-QDT 892
                           |.:|:|||||:|||:.|:||||||||||::.|.::||.|||||||| .|:
Mouse   783 SDDDSEGLTLLDLLSFTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDS 847

  Fly   893 EYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLIT 957
            .|..|.:. .||:|||||||:.:..|.:.|||||||:|||||.:.|..|||.::.....|:.:.:
Mouse   848 NYVSKGST-FLPVKWMAPESIFDNLYTTLSDVWSYGILLWEIFSLGGTPYPGMMVDSTFYNKIKS 911

  Fly   958 GQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGIL 1000
            |.||.||...:..:|.:|.|||:.|...||:|..|.|..:.:|
Mouse   912 GYRMAKPDHATSEVYEIMVQCWNSEPEKRPSFYHLSEIVENLL 954

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	14/82 (17%)
		IGc2	157..215	CDD:197706	11/57 (19%)
		IG	247..336	CDD:214652	19/90 (21%)
		Ig	258..340	CDD:143165	16/83 (19%)
		I-set	394..479	CDD:254352	26/94 (28%)
		IGc2	408..469	CDD:197706	20/69 (29%)
		IG_like	492..583	CDD:214653	24/112 (21%)
		Ig	507..583	CDD:299845	21/91 (23%)
		PKc_like	700..1000	CDD:304357	143/375 (38%)
		TyrKc	712..996	CDD:197581	136/359 (38%)
Pdgfra	NP_001076785.1	Ig_3	28..100	CDD:372822	13/56 (23%)
		Ig_PDGFR-alphabeta	228..311	CDD:143269	21/120 (18%)
		Ig4_PDGFR	313..413	CDD:143267	27/124 (22%)
		Ig_TrkABC_d4	416..497	CDD:143173	16/86 (19%)
		PTKc_PDGFR_alpha	555..956	CDD:173653	149/409 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1018..1089
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5217
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.760