DRSC/TRiP Functional Genomics Resources

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Protein Alignment btl and Ntrk2

DIOPT Version :10

Sequence 1:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_001020245.1 Gene:Ntrk2 / 18212 MGIID:97384 Length:821 Species:Mus musculus


Alignment Length:893 Identity:230/893 - (25%)
Similarity:357/893 - (39%) Gaps:211/893 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   227 PTQLEVISRKHTVPMLKPG---YPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLL 288
            ||..:..|.:.......||   :||               ||.::::|          :||.::|
Mouse    33 PTSCKCSSARIWCTEPSPGIVAFPR---------------LEPNSVDP----------ENITEIL 72

  Fly   289 QRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGW----YICIAENQVGRTVAASYVDLYSP 349
              :..|.:|     .:|...|....:.|.|:.:.|.|.    |....:|...|.:..:...|.|.
Mouse    73 --IANQKRL-----EIINEDDVEAYVGLRNLTIVDSGLKFVAYKAFLKNSNLRHINFTRNKLTSL 130

  Fly   350 SD--------TTTVRTTTTTTVASPIPTASTGED-------------NDDDVENPAAEAS-GGVG 392
            |.        :..:.|....|.:..|....|.::             |:.....|.|... ...|
Mouse   131 SRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNMPLANLQIPNCG 195

  Fly   393 PPVFRKELKRLQHSLSGNTVNLACPVYGKANITWTKDKKP-LNRELGVYVQKNW--------TLR 448
            .|..|.....|... .|.:|.|:|.|.|        |..| |..::|..|.|:.        :||
Mouse   196 LPSARLAAPNLTVE-EGKSVTLSCSVGG--------DPLPTLYWDVGNLVSKHMNETSHTQGSLR 251

  Fly   449 FVEATSEDSG-LYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSD 512
            ....:|:||| ..:|...|..|    :....:|.....||.|...::.|...:..:..  ||..:
Mouse   252 ITNISSDDSGKQISCVAENLVG----EDQDSVNLTVHFAPTITFLESPTSDHHWCIPF--TVRGN 310

  Fly   513 LHPTVSWKRVVLKNASLDGLKSV--EIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRS 575
            ..|.:.|   ....|.|:..|.:  :|...|.|..:.  .|.|.|.|....|.||.:|.:..|:.
Mouse   311 PKPALQW---FYNGAILNESKYICTKIHVTNHTEYHG--CLQLDNPTHMNNGDYTLMAKNEYGKD 370

  Fly   576 NSSV-----------------YLRVV-----------------SPLPP-----------LEIYA- 594
            ...:                 |..|:                 :.:|.           |.:|| 
Mouse   371 ERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQSNREHLSVYAV 435

  Fly   595 LLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGS 659
            ::.|..:||.|    :|.|.||          :|.|.....::                 |....
Mouse   436 VVIASVVGFCL----LVMLLLL----------KLARHSKFGMK-----------------GPASV 469

  Fly   660 GCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSN-----------------WEI 707
            ..:..|...|:..|.....|.|:: .||.| |......:.|:..|                 ..|
Mouse   470 ISNDDDSASPLHHISNGSNTPSSS-EGGPD-AVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHI 532

  Fly   708 PRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMI 772
            .|..:.|...|||||||:|.:||...|  .|:..:.:||||.:|:. :|.......||.|::..:
Mouse   533 KRHNIVLKRELGEGAFGKVFLAECYNL--CPEQDKILVAVKTLKDA-SDNARKDFHREAELLTNL 594

  Fly   773 GKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLG 837
             :|.:|:...|.|.:|.||.::.||..||:|..||:.:.|.|...   ::|   :.|...||   
Mouse   595 -QHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLM---AEG---NPPTELTQ--- 649

  Fly   838 EKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGR 902
             .::...|.|||.||.||||:..:|||||.||.||.:..::||.|||::||:..|:|||...:..
Mouse   650 -SQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTM 713

  Fly   903 LPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKC 967
            |||:||.|||:..:|:.::|||||.||:||||.|||.||: :.||..|:...:..|:.:::|..|
Mouse   714 LPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPW-YQLSNNEVIECITQGRVLQRPRTC 777

  Fly   968 SLNIYVVMRQCWHFESCARPTFAELVESFDGILQQ-ASSNPNDAYLDL 1014
            ...:|.:|..||..|    |...:.::|...:||. |.::|  .|||:
Mouse   778 PQEVYELMLGCWQRE----PHTRKNIKSIHTLLQNLAKASP--VYLDI 819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btlNP_729956.1 Ig 143..215 CDD:472250
Ig strand B 160..164 CDD:409570
Ig strand C 175..179 CDD:409570
Ig strand E 197..201 CDD:409570
Ig strand F 211..215 CDD:409570
Ig_3 247..333 CDD:464046 17/89 (19%)
Ig 398..479 CDD:472250 22/90 (24%)
Ig strand B 412..416 CDD:409393 2/3 (67%)
Ig strand C 423..427 CDD:409393 0/3 (0%)
Ig strand E 445..449 CDD:409393 1/11 (9%)
Ig strand F 459..464 CDD:409393 1/4 (25%)
Ig strand G 472..475 CDD:409393 0/2 (0%)
IG_like 492..583 CDD:214653 21/109 (19%)
Ig strand B 503..507 CDD:409444 0/3 (0%)
Ig strand C 516..520 CDD:409444 0/3 (0%)
Ig strand E 549..553 CDD:409444 1/3 (33%)
Ig strand F 563..568 CDD:409444 2/4 (50%)
Ig strand G 576..579 CDD:409444 0/2 (0%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 114/316 (36%)
Ntrk2NP_001020245.1 LRR_8 92..150 CDD:404697 11/57 (19%)
LRR 1 92..113 5/20 (25%)
LRR 2 116..137 4/20 (20%)
LRRCT_2 151..195 CDD:465313 6/43 (14%)
Ig 205..283 CDD:472250 23/90 (26%)
Ig strand B 214..218 CDD:409353 2/3 (67%)
Ig strand C 227..230 CDD:409353 1/2 (50%)
Ig strand E 245..252 CDD:409353 1/6 (17%)
Ig strand F 262..268 CDD:409353 1/5 (20%)
Ig strand G 276..279 CDD:409353 0/2 (0%)
IgI_TrkB_d5 286..379 CDD:409441 23/99 (23%)
Ig strand A 286..294 CDD:409441 3/7 (43%)
Ig strand A' 295..298 CDD:409441 1/2 (50%)
Ig strand B 301..309 CDD:409441 2/9 (22%)
Ig strand C 312..319 CDD:409441 2/9 (22%)
Ig strand C' 322..325 CDD:409441 1/2 (50%)
Ig strand D 330..335 CDD:409441 0/4 (0%)
Ig strand E 341..349 CDD:409441 1/9 (11%)
Ig strand F 357..365 CDD:409441 4/7 (57%)
Ig strand G 368..376 CDD:409441 1/7 (14%)
Interaction with MAPK8IP3/JIP3. /evidence=ECO:0000250|UniProtKB:Q63604 454..465 2/27 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 474..497 6/23 (26%)
PTKc_TrkB 531..818 CDD:270675 117/307 (38%)
Blue background indicates that the domain is not in the aligned region.

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