DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and ver-3

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_509836.1	Gene:	ver-3 / 181289	WormBaseID:	WBGene00006896	Length:	1227	Species:	Caenorhabditis elegans

Alignment Length:	1149	Identity:	259/1149 - (22%)
Similarity:	427/1149 - (37%)	Gaps:	338/1149 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 MDITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRW----YNISLVV----- 104
            :|:..:|       .|:.:....||.:..|:..|.:.|.:...:...:|    ||.||..
Worm   198 VDVNFEC-------RYKKEENQTATYIITEKEASSDDGYHFSWEKGFQWPHVGYNFSLTCNLNYN 255

  Fly   105 GHKEPVGNDIASFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDP 169
            |.|                        .|.......|::..|                 || .||
Worm   256 GSK------------------------IFHGYTNKLSIECPQ-----------------CS-HDP 278

  Fly   170 DAKGVNISWLHNDTQILGGRGRIKLKRWSLTV--GQLQPEDAGSYHCELCVEQDCQRSNPT---- 228
            .      |.:|.|      |.||...:.|.||  ..|:.||:|.|.|  ..|.:.:.:..|
Worm   279 G------SHVHVD------RHRIIGNKISTTVRIQHLELEDSGKYTC--IWEHENKETKYTDYHL 329

  Fly   229 -------QLEVISRKHTVPMLKPG-----------YP-------------RNTSIALGDNVSIEC 262
                   |::||....|:..:|..           ||             .|:||..|.  ..|.
Worm   330 YVAPKKAQIKVIETSPTIMRIKENRATSLTAKFAIYPFEKESYTAKWSRIYNSSIHEGP--QSET 392

  Fly   263 LLEDSALEPKITWLHKGN-ADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGW 326
            ::.|...:...|....|. ::|:|  ::.....:.:.......|:.||..||::          |
Worm   393 IINDDFRKIAATSFGDGAFSENLD--IKAFAVSTNMSGTYVLSISHMDTVQVVQ----------W 445

  Fly   327 YICIA--ENQVGRTVA------ASYVDLYSPSDTTTVRTTTTTTVASPIPTA-------STGEDN 376
            .:.|.  |..|..||.      .|..:.|.|.....:.     .::..||.|       :...:.
Worm   446 EVAIENDEPDVQITVREPSSFFISNQEYYKPDTNLHIE-----CISISIPPADVVFEYKTKNSEQ 505

  Fly   377 DDDVENPAAEASGG-------------------------------------VGP-----PVFRKE 399
            ..::|.....:.||                                     :|.     |...|.
Worm   506 FQEIEPNKLVSVGGTFDRGLIYNVTFTEGMDLKCSSIRKGNRAITVNKLIKIGEGFEVRPHHEKS 570

  Fly   400 LKRLQHSLS-----GNTVNLACPVYGKANITWT-----KDKK-------PLNRELGV-YVQKNWT 446
            .|..:...|     |:.|.|.| |:...:..|:     ::.|       |...|..: ...|:..
Worm   571 SKATESEPSKIIYEGDNVKLTC-VFPLDSDDWSVSWRFENSKSSDISSIPTTTETEIKQYSKHLI 634

  Fly   447 LRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTR-------SAPIIVVPQNQTVKVNGSLV 504
            |...:.|:..:|.|.|.|.|.......:.|:.:...::       |..:::|..:|..::|
Worm   635 LNLRDVTTSFTGTYTCVVKNEDSEKLLETSIDVKAISKPSITGGNSNAVVIVDYDQYFEIN---- 695

  Fly   505 MKCTVYSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLAS 569
              |.:.....|...|.:        ||       |.......|..:|.:.....:.:|.:.|||:
Worm   696 --CNMTGTPPPVYQWFK--------DG-------NPYTHGDVDGSILRVSRARGEDDGEFHCLAT 743

  Fly   570 SGLGRSNSSVYLRV-VSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLR---RLRR 630
            :..|...:|:.::| .:|...|..|..|      ..|..|:|:|:|||     |..||   ||.:
Worm   744 NRAGDKLNSIEVQVNNAPKGSLFFYWFL------ALLLLISIIAVFLL-----TCKLRASNRLTK 797

  Fly   631 EKLLKLR--IETV--HQWTKKVIIYRPGGEEGSGCSSGDL-----QMPVIRIEKQRTTVSTTGTG 686
            :|.:.|.  .||:  ||                   :|.|     .:||    ::||
Worm   798 QKDIALNTLYETMIKHQ-------------------AGPLPEEMKDLPV----EERT-------- 831

  Fly   687 GTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGL--PRSPQLAET--IVAV 747
                      |..|.::::||....|.:.:.:|.|.|| ||.....|:  |:|...::|  .|||
Worm   832 ----------YYLPYNNDYEIDPVNLEILNPIGSGHFG-VVKKGLLGMAYPKSKIESKTRLPVAV 885

  Fly   748 KMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQG---GPLWVIVEYAPHGNLKDFLKQ 809
            |.............:..|::||..|.|:.|::.|:|..::.   |.|:::.|:...|||::||:.
Worm   886 KSSTNPFNVELQKMMAEELKVMCAIPKNPNVLALIGAVTKNMRQGQLYIVTEFIDGGNLREFLQA 950

  Fly   810 NR-PGAPQRRSDSDGYLDDKPLIST----------QHLGE--------------KELTKFAFQIA 849
            :| ....:...|....:||..|:..          :.|||              .:|.....|||
Worm   951 HRNTFINELVEDEHVPVDDSYLVPNSVKKKIYKFDEKLGEGTRLLVEDPDALCTSDLLSIGLQIA 1015

  Fly   850 RGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYR--KNTNGRLPIKWMAPES 912
            :||.:||...|:|||||.||||::...:::||||||::...:..|||  |:.:..||::||..|.
Worm  1016 KGMAWLADVPCVHRDLACRNVLITKTKIVRIADFGLSKKHTNKTYYRTKKSKDTPLPVRWMPLEC 1080

  Fly   913 LQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQ 977
            ::|.|:..:|||||:|:.|:||.|.|..|||: .....:..::..|.|.::|..|...||.:|:.
Worm  1081 IEEFKFTQKSDVWSFGICLYEIFTLGGTPYPN-CDTFNVIEFIRNGNRNKQPEYCHDEIYELMKV 1144

  Fly   978 CWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLET 1021
            ||.|....||||.:.:..|:..::.:||.    :|:....||.|
Worm  1145 CWQFNPKDRPTFNDCITFFENHMRDSSSQ----FLERVENMLHT 1184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	22/95 (23%)
		IGc2	157..215	CDD:197706	18/59 (31%)
		IG	247..336	CDD:214652	19/104 (18%)
		Ig	258..340	CDD:143165	16/84 (19%)
		I-set	394..479	CDD:254352	22/102 (22%)
		IGc2	408..469	CDD:197706	18/78 (23%)
		IG_like	492..583	CDD:214653	16/90 (18%)
		Ig	507..583	CDD:299845	14/75 (19%)
		PKc_like	700..1000	CDD:304357	106/333 (32%)
		TyrKc	712..996	CDD:197581	102/317 (32%)
ver-3	NP_509836.1	IG	242..>313	CDD:214652	27/124 (22%)
		IG_like	578..667	CDD:214653	19/89 (21%)
		Ig_3	578..654	CDD:290638	17/76 (22%)
		I-set	673..757	CDD:254352	18/104 (17%)
		IGc2	692..747	CDD:197706	13/75 (17%)
		STYKc	847..1163	CDD:214568	102/317 (32%)
		PTKc	851..1164	CDD:270623	101/314 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910