DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and igcm-4

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_508377.1	Gene:	igcm-4 / 180518	WormBaseID:	WBGene00022418	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	438	Identity:	91/438 - (20%)
Similarity:	157/438 - (35%)	Gaps:	107/438 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 DCQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNID 285
            :..|..|.::..:..|..:|:.:..:.....|     ::.|   :||.:   |.|  ..|.:.:|
Worm    27 EAARGMPPRMRNVETKFRIPLGQKQFRLVCPI-----IATE---KDSTM---IQW--SKNGEQLD 78

  Fly   286 -DLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSP 349
             |...:|.:.|                :.|::.:|..||.|.|.|.|.|..|.......|.::..
Worm    79 WDSQYKLSKDS----------------KELKMKSVKFEDSGRYQCQATNGFGHKTIEFIVHVHDQ 127

  Fly   350 SD-TTTVR--TTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSLSGNT 411
            .| ..:|:  ...:.|.|||    |...|.:.:..:|....:||                    .
Worm   128 HDKENSVKDYLVLSNTTASP----SWLIDMNSEWRSPIKINTGG--------------------K 168

  Fly   412 VNLACPVYGK--ANITWTKDKKPLNRELGVYVQKNWTLRFVEATSEDSGLYNCKVCNAWGCIQFD 474
            :.|.||..|.  ..|.|.:::..::.:...:|.   |:......|..||:|.|.|.|..|.:.|.
Worm   169 LELRCPAQGNPLPEIRWYQNEMEISEKTHKHVS---TITVEPVESSHSGVYRCVVENPLGSLSFA 230

  Fly   475 FSVQIND-------------RTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKN 526
            |.|.:.|             .|...|:|..|.|.:|....:...:|.|.|:.:..:.|.:.|...
Worm   231 FDVSVGDFFDPTTTEATEYQETAMEPVIDQPYNISVYAGHTAQFQCKVKSNENTIIKWLKEVSDP 295

  Fly   527 ASL----DGLKSVEIQNLNFTVTN-------------DSVV---LTLRNVTFDQEGWYTCLASSG 571
            .|:    .....:.:..:|..|.:             |::.   ||:..|.:...|.|.|:.:|.
Worm   296 LSIRRKDPNSTVIHVNGMNLLVLDHIQTESSLPQEDMDNIYTNRLTIHKVDYHHAGKYICVVTSA 360

  Fly   572 LGR-SNSSVYLRVVSPLPPLEIYALLHAHPL---GFTLAAITIVALFL 615
            .|: ...|..|:|:|        |.....|.   ||.:....:|.||:
Worm   361 QGQIVYKSAELKVLS--------AYDFTFPFKSDGFLVLLAVVVTLFI 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	2/10 (20%)
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	20/89 (22%)
		Ig	258..340	CDD:143165	20/82 (24%)
		I-set	394..479	CDD:254352	19/86 (22%)
		IGc2	408..469	CDD:197706	15/62 (24%)
		IG_like	492..583	CDD:214653	22/111 (20%)
		Ig	507..583	CDD:299845	19/96 (20%)
		PKc_like	700..1000	CDD:304357
		TyrKc	712..996	CDD:197581
igcm-4	NP_508377.1	IGc2	52..114	CDD:197706	20/90 (22%)
		I-set	159..235	CDD:254352	22/98 (22%)
		IGc2	166..225	CDD:197706	17/81 (21%)
		IG_like	261..373	CDD:214653	22/111 (20%)
		Ig	269..374	CDD:299845	19/104 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810