DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment btl and Kdr

DIOPT Version :9

Sequence 1:NP_001014583.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_034742.2 Gene:Kdr / 16542 MGIID:96683 Length:1345 Species:Mus musculus


Alignment Length:1280 Identity:315/1280 - (24%)
Similarity:473/1280 - (36%) Gaps:435/1280 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LGCDYGHHRC-YIDVTV-----------------------------ENSPRQ-----RHLLSDMD 50
            :|.|.|.::| |.||.:                             ||..:.     |..:|:::
Mouse    96 VGNDTGAYKCSYRDVDIASTVYVYVRDYRSPFIASVSDQHGIVYITENKNKTVVIPCRGSISNLN 160

  Fly    51 ITLQCVRPMAKWFYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNISLVVGHKEPVGNDIA 115
            ::| |.|...|.|..|                   ||....||:               :|..:.
Mouse   161 VSL-CARYPEKRFVPD-------------------GNRISWDSE---------------IGFTLP 190

  Fly   116 SFV-----------KLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDP 169
            |::           |:.|...  :|.::...:...|...::...|..::.:||....|||:....
Mouse   191 SYMISYAGMVFCEAKINDETY--QSIMYIVVVVGYRIYDVILSPPHEIELSAGEKLVLNCTARTE 253

  Fly   170 DAKGVNISW------------LHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDC 222
            ...|::.:|            ::.|.:...|. ..|:...:||:..:...|.|.|.|.....:..
Mouse   254 LNVGLDFTWHSPPSKSHHKKIVNRDVKPFPGT-VAKMFLSTLTIESVTKSDQGEYTCVASSGRMI 317

  Fly   223 QRSNPTQLEVISRKHTVPMLKPGYPRNTSI--ALGDNVSIEC-LLEDSALEPKITWLHKGNADNI 284
            :|:     ....|.||.|.:..|....:.:  .:|..|.|.. .|...|  |.|.|...|.    
Mouse   318 KRN-----RTFVRVHTKPFIAFGSGMKSLVEATVGSQVRIPVKYLSYPA--PDIKWYRNGR---- 371

  Fly   285 DDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVD---- 345
                         |::....:...||   |.:..|...|.|.|..|..|.:.....:..|.    
Mouse   372 -------------PIESNYTMIVGDE---LTIMEVTERDAGNYTVILTNPISMEKQSHMVSLVVN 420

  Fly   346 ---------LYSPSDT---TTVRTTTTTTVASPIPTASTGEDNDDDVENP------------AAE 386
                     |.||.|:   .|::|.|.|..|:|                |            |..
Mouse   421 VPPQIGEKALISPMDSYQYGTMQTLTCTVYANP----------------PLHHIQWYWQLEEACS 469

  Fly   387 ASGGVGPPVFRKELKRLQHSLSGNTVNLA-----------------------------CPVYGKA 422
            ...|...|...||.:.::....||.:.:.                             |....||
Mouse   470 YRPGQTSPYACKEWRHVEDFQGGNKIEVTKNQYALIEGKNKTVSTLVIQAANVSALYKCEAINKA 534

  Fly   423 -------------------------------------------NITWTK------------DKKP 432
                                                       |:||.|            ...|
Mouse   535 GRGERVISFHVIRGPEITVQPAAQPTEQESVSLLCTADRNTFENLTWYKLGSQATSVHMGESLTP 599

  Fly   433 LNRELGVYVQKNWTL-----------RFVEATSEDSGLYNCKVCNAWG-------CIQFDFSVQI 479
            :.:.|....:.|.|:           .|..|:.:|.|.|   ||:|..       |:    ..|:
Mouse   600 VCKNLDALWKLNGTMFSNSTNDILIVAFQNASLQDQGDY---VCSAQDKKTKKRHCL----VKQL 657

  Fly   480 NDRTRSAPIIVVP-QNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDGLKSVEIQNLNFT 543
            ....|.||:|... :|||..:..::.:.|....:..|.::|    .|:              |.|
Mouse   658 IILERMAPMITGNLENQTTTIGETIEVTCPASGNPTPHITW----FKD--------------NET 704

  Fly   544 VTNDSVV--------LTLRNVTFDQEGWYTCLASSGLG--RSNSSVYLRVVSPLPPLEIYALLHA 598
            :..||.:        ||:|.|..:..|.|||.|.:.||  |:.:...:........||:      
Mouse   705 LVEDSGIVLRDGNRNLTIRRVRKEDGGLYTCQACNVLGCARAETLFIIEGAQEKTNLEV------ 763

  Fly   599 HPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSS 663
                          :.|:|:|.|....                  |...||:.|    .....:.
Mouse   764 --------------IILVGTAVIAMFF------------------WLLLVIVLR----TVKRANE 792

  Fly   664 GDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLD----------SNWEIPRQQLSLGSIL 718
            |:|:...:.|.             .||.      |.|||          |.||.||.:|.||..|
Mouse   793 GELKTGYLSIV-------------MDPD------ELPLDERCERLPYDASKWEFPRDRLKLGKPL 838

  Fly   719 GEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLG 783
            |.||||:|:.|:|.|:.::...  ..|||||:||..|.::..:|:.|::::..||.|:|::||||
Mouse   839 GRGAFGQVIEADAFGIDKTATC--KTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLG 901

  Fly   784 CCSQ-GGPLWVIVEYAPHGNLKDFLKQNR--------PGAP---------------QRRSD---- 820
            .|:: ||||.||||:...|||..:|:..|        .||.               :||.|    
Mouse   902 ACTKPGGPLMVIVEFCKFGNLSTYLRGKRNEFVPYKSKGARFRQGKDYVGELSVDLKRRLDSITS 966

  Fly   821 -----SDGYLDDKPLIST-QHLGEKELTK----------FAFQIARGMEYLASRRCIHRDLAARN 869
                 |.|::::|.|... :....:||.|          ::||:|:|||:||||:||||||||||
Mouse   967 SQSSASSGFVEEKSLSDVEEEEASEELYKDFLTLEHLICYSFQVAKGMEFLASRKCIHRDLAARN 1031

  Fly   870 VLVSDGYVMKIADFGLARDI-QDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWE 933
            :|:|:..|:||.|||||||| :|.:|.||. :.|||:||||||::.::.|..||||||:||||||
Mouse  1032 ILLSEKNVVKICDFGLARDIYKDPDYVRKG-DARLPLKWMAPETIFDRVYTIQSDVWSFGVLLWE 1095

  Fly   934 IMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDG 998
            |.:.|..|||.:...||....|..|.||..|...:..:|..|..|||.:...||:|:||||....
Mouse  1096 IFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTMLDCWHEDPNQRPSFSELVEHLGN 1160

  Fly   999 ILQQASSNPNDAYLDLSMPMLETPPSSGDEDDGSDTETFRETSPL 1043
            :||..:......|:.|  ||.||  .|.:||.|...    .|||:
Mouse  1161 LLQANAQQDGKDYIVL--PMSET--LSMEEDSGLSL----PTSPV 1197

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btlNP_001014583.1 IG_like 149..232 CDD:214653 18/94 (19%)
IGc2 157..215 CDD:197706 14/69 (20%)
IG 247..336 CDD:214652 19/91 (21%)
Ig 258..340 CDD:143165 18/82 (22%)
I-set 394..479 CDD:254352 25/186 (13%)
IGc2 408..469 CDD:197706 21/155 (14%)
IG_like 492..583 CDD:214653 23/101 (23%)
Ig 507..583 CDD:299845 20/85 (24%)
PKc_like 700..1000 CDD:304357 148/354 (42%)
TyrKc 712..996 CDD:197581 140/328 (43%)
KdrNP_034742.2 Ig_3 31..105 CDD:404760 3/8 (38%)
Ig 226..327 CDD:416386 19/106 (18%)
Ig strand A 226..230 CDD:409353 0/3 (0%)
Ig strand A' 236..240 CDD:409353 0/3 (0%)
Ig strand B 242..251 CDD:409353 3/8 (38%)
Ig strand C 258..263 CDD:409353 0/4 (0%)
Ig strand C' 266..268 CDD:409353 0/1 (0%)
Ig strand D 272..280 CDD:409353 1/7 (14%)
Ig strand E 288..296 CDD:409353 2/7 (29%)
Ig strand F 306..312 CDD:409353 2/5 (40%)
Ig strand G 317..323 CDD:409353 1/10 (10%)
Ig 331..419 CDD:416386 21/109 (19%)
Ig strand A 331..334 CDD:409353 0/2 (0%)
Ig strand A' 341..345 CDD:409353 0/3 (0%)
Ig strand B 347..358 CDD:409353 3/10 (30%)
Ig strand C 362..368 CDD:409353 3/5 (60%)
Ig strand C' 370..373 CDD:409353 1/19 (5%)
Ig strand D 378..381 CDD:409353 0/2 (0%)
Ig strand E 383..388 CDD:409353 3/7 (43%)
Ig strand F 396..404 CDD:409353 3/7 (43%)
Ig strand G 410..419 CDD:409353 1/8 (13%)
Ig_3 549..643 CDD:404760 15/96 (16%)
I-set 665..742 CDD:400151 22/94 (23%)
Ig strand B 682..686 CDD:409353 0/3 (0%)
Ig strand C 695..699 CDD:409353 1/7 (14%)
Ig strand E 718..722 CDD:409353 1/3 (33%)
Ig strand F 732..737 CDD:409353 3/4 (75%)
VEGFR-2_TMD 757..791 CDD:375470 10/75 (13%)
PTKc_VEGFR2 824..1165 CDD:270681 146/343 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1272..1316
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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