DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment btl and CSF1R

DIOPT Version :9

Sequence 1:NP_001014583.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster
Sequence 2:NP_001275634.1 Gene:CSF1R / 1436 HGNCID:2433 Length:972 Species:Homo sapiens


Alignment Length:1131 Identity:288/1131 - (25%)
Similarity:436/1131 - (38%) Gaps:327/1131 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    51 ITLQCV---------RPMAKW-FYEDKFQLRATLLRLERAQSGNSGNYGCLDSQNRWYNISLVVG 105
            :||:||         .|...| .|.|.   .:::|....|...|:|.|.|.:.            
Human    38 VTLRCVGNGSVEWDGPPSPHWTLYSDG---SSSILSTNNATFQNTGTYRCTEP------------ 87

  Fly   106 HKEPVGNDIASFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQ-----LNCS 165
             .:|:|...|..:.::| ||.|.:.|..:.:                      :|:     |.|.
Human    88 -GDPLGGSAAIHLYVKD-PARPWNVLAQEVV----------------------VFEDQDALLPCL 128

  Fly   166 PMDPDAKGVNISWLHNDTQILGGRGRIKLKR-------W-SLTVGQLQPEDAGSYHCELCVEQDC 222
            ..||        .|.....::..|||..::.       | ..|:.:.:...:..|.|...:    
Human   129 LTDP--------VLEAGVSLVRVRGRPLMRHTNYSFSPWHGFTIHRAKFIQSQDYQCSALM---- 181

  Fly   223 QRSNPTQLEVISRKHTVPMLKPGYPRNTSIAL------GDNVSIECLLEDSALEPKITWLHKGNA 281
               ...::..||.:..|..:.||.|..|.:..      |:...|.|    ||....:        
Human   182 ---GGRKVMSISIRLKVQKVIPGPPALTLVPAELVRIRGEAAQIVC----SASSVDV-------- 231

  Fly   282 DNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVG--------RT 338
             |.|..||....:..:|........|..:...|.|..|..:..|.|.|:|.|..|        |.
Human   232 -NFDVFLQHNNTKLAIPQQSDFHNNRYQKVLTLNLDQVDFQHAGNYSCVASNVQGKHSTSMFFRV 295

  Fly   339 VAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRL 403
            |.::|::|.|                                                  |...:
Human   296 VESAYLNLSS--------------------------------------------------EQNLI 310

  Fly   404 QHSLSGNTVNLACPVY---GKANITWT-----KDKKP----LNRELGVYVQKNWTLRFVEATSED 456
            |....|..:||...|.   |.....||     .|.:|    .|.......:..:||........:
Human   311 QEVTVGEGLNLKVMVEAYPGLQGFNWTYLGPFSDHQPEPKLANATTKDTYRHTFTLSLPRLKPSE 375

  Fly   457 SGLYNCKVCN--AWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKVNGSLVMKCTVYSDLHPTVSW 519
            :|.|:....|  .|..:.|:.::      |..|.:.|   ....:|||..:.|.......|.|:|
Human   376 AGRYSFLARNPGGWRALTFELTL------RYPPEVSV---IWTFINGSGTLLCAASGYPQPNVTW 431

  Fly   520 KRVVLKNASLDGLKSVEI----------QNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGR 574
            .:........|..:.:::          |.....||..| :||:..:..:|.  |.|.|.:.:| 
Human   432 LQCSGHTDRCDEAQVLQVWDDPYPEVLSQEPFHKVTVQS-LLTVETLEHNQT--YECRAHNSVG- 492

  Fly   575 SNSSVYLRVVSPLPPLEIYALLHAHP---LGFT---LAAITIVALFLLGSAFITFMLRRLRREKL 633
            |.|..:         :.|.|..|.||   ..||   :|.::|:||.||   .:..:|.:.:::..
Human   493 SGSWAF---------IPISAGAHTHPPDEFLFTPVVVACMSIMALLLL---LLLLLLYKYKQKPK 545

  Fly   634 LKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYE 698
            .::|.:.:..:            ||:..:.                        .||.|      
Human   546 YQVRWKIIESY------------EGNSYTF------------------------IDPTQ------ 568

  Fly   699 FPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKE-EHTDTDMASL 762
            .|.:..||.||..|..|..||.||||:||.|.|.||.:...:.:  |||||:|. .|.| :..:|
Human   569 LPYNEKWEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKEDAVLK--VAVKMLKSTAHAD-EKEAL 630

  Fly   763 VREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQN---------RPGAPQR- 817
            :.|:::|..:|:|.||:||||.|:.|||:.||.||..:|:|.:||::.         .||.... 
Human   631 MSELKIMSHLGQHENIVNLLGACTHGGPVLVITEYCCYGDLLNFLRRKAEAMLGPSLSPGQDPEG 695

  Fly   818 --------------RSDS-------DGYLDDKPL-------ISTQHLGE--------KELTKFAF 846
                          |.||       |.|::.:|:       .|.|.|.:        ::|..|:.
Human   696 GVDYKNIHLEKKYVRRDSGFSSQGVDTYVEMRPVSTSSNDSFSEQDLDKEDGRPLELRDLLHFSS 760

  Fly   847 QIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPE 911
            |:|:||.:|||:.|||||:||||||:::|:|.||.||||||||.:...|....|.|||:||||||
Human   761 QVAQGMAFLASKNCIHRDVAARNVLLTNGHVAKIGDFGLARDIMNDSNYIVKGNARLPVKWMAPE 825

  Fly   912 SLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMR 976
            |:.:..|..||||||||:|||||.:.|..|||.||...:.|..:..|.:|.:||....|||.:|:
Human   826 SIFDCVYTVQSDVWSYGILLWEIFSLGLNPYPGILVNSKFYKLVKDGYQMAQPAFAPKNIYSIMQ 890

  Fly   977 QCWHFESCARPTFAELVESFDGILQQASSNPNDA-YLDLSMPMLETPPSSGDEDDGSDTETFRET 1040
            .||..|...||||.::. ||  :.:||..:..:. |.:|       |.||.....||.:....|.
Human   891 ACWALEPTHRPTFQQIC-SF--LQEQAQEDRRERDYTNL-------PSSSRSGGSGSSSSELEEE 945

  Fly  1041 S---------------PLRYQYTYKF 1051
            |               ||.....|:|
Human   946 SSSEHLTCCEQGDIAQPLLQPNNYQF 971

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btlNP_001014583.1 IG_like 149..232 CDD:214653 13/95 (14%)
IGc2 157..215 CDD:197706 12/70 (17%)
IG 247..336 CDD:214652 21/94 (22%)
Ig 258..340 CDD:143165 20/89 (22%)
I-set 394..479 CDD:254352 19/98 (19%)
IGc2 408..469 CDD:197706 15/74 (20%)
IG_like 492..583 CDD:214653 21/100 (21%)
Ig 507..583 CDD:299845 18/85 (21%)
PKc_like 700..1000 CDD:304357 143/346 (41%)
TyrKc 712..996 CDD:197581 136/330 (41%)
CSF1RNP_001275634.1 IG_like 28..85 CDD:214653 13/49 (27%)
ig 207..293 CDD:365836 20/98 (20%)
Ig4_SCFR_like 299..400 CDD:319281 22/156 (14%)
Ig 416..495 CDD:319273 17/82 (21%)
Regulatory juxtamembrane domain 542..574 7/73 (10%)
PTKc_CSF-1R 543..914 CDD:133237 149/418 (36%)
Activation loop 796..818 11/21 (52%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 918..950 9/38 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0200
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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