DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Flt4

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_032055.1	Gene:	Flt4 / 14257	MGIID:	95561	Length:	1363	Species:	Mus musculus

Alignment Length:	1171	Identity:	293/1171 - (25%)
Similarity:	450/1171 - (38%)	Gaps:	374/1171 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 SDLFFQPL--NESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDAKGVNISWLHNDTQILGGRGR 191
            |:||...:  ||...::|..  .|:::...|....|||:.......||...|.:...|  ..|.:
Mouse   217 SNLFVVHITGNELYDIQLYP--KKSMELLVGEKLVLNCTVWAEFDSGVTFDWDYPGKQ--AERAK 277

  Fly   192 IKLKRWS----------LTVGQLQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKHTV------- 239
            ...:|.|          ||:..:...|.|.|.||  .....||...:...::..|..:
Mouse   278 WVPERRSQQTHTELSSILTIHNVSQNDLGPYVCE--ANNGIQRFRESTEVIVHEKPFISVEWLKG 340

  Fly   240 --------------PMLKPGYPR---------------------------------------NTS 251
                          |:....||.                                       |::
Mouse   341 PVLEATAGDELVKLPVKLAAYPPPEFQWYKDRKAVTGRHNPHALVLKEVTEASAGVYTLALWNSA 405

  Fly   252 IALGDNVSIECLL-------EDSALEPKITWLHKG-----NADNIDDLL---------------- 288
            ..|..|:|:|.::       |..|..|.|...|..     .|..:...|
Mouse   406 AGLRQNISLELVVNVPPHIHEKEASSPSIYSRHSRQTLTCTAYGVPQPLSVQWHWRPWTPCKTFA 470

  Fly   289 QR-LREQSQL-------------------PVDVTRLITRMDEPQVLRLGNVLMED---GGWYICI 330
            || ||.:.|.                   |::.....|...|.:...:..::::|   ...|.|:
Mouse   471 QRSLRRRQQRDGMPQCRDWKEVTTQDAVNPIESLDSWTEFVEGKNKTVSKLVIQDANVSAMYKCV 535

  Fly   331 AENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPV 395
            ..|:||:.....|  .|            .||:  |...:...|.::|.:|..:...|.......
Mouse   536 VVNKVGQDERLIY--FY------------VTTI--PDGFSIESEPSEDPLEGQSVRLSCRADNYT 584

  Fly   396 ------FRKELKRLQHSLSGNTVNLAC--------PVYGKANITWTKDKKPLNRELGVYVQKNWT 446
                  :|..|..| |...||.:.|.|        |:  :||:   ::.:|..|...:      :
Mouse   585 YEHLRWYRLNLSTL-HDAQGNPLLLDCKNVHLFATPL--EANL---EEAEPGARHATL------S 637

  Fly   447 LRFVEATSEDSGLYNCKVCNAWG----CIQFDFSVQINDRTRSAPIIVVPQNQT---VKVNGSLV 504
            |.......||.|.|.|:|.:...    |.:...|||..:..|      :.||.|   |.|:.||.
Mouse   638 LNIPRVAPEDEGDYVCEVQDRRSQDKHCHKKYLSVQALEAPR------LTQNLTDLLVNVSDSLE 696

  Fly   505 MKCTVYSDLHPTVSW---KRVVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTC 566
            |:|.|.....|::.|   :|::.|.:.:|             :.:.:..|:::.|..:..|.|.|
Mouse   697 MRCPVAGAHVPSIVWYKDERLLEKESGID-------------LADSNQRLSIQRVREEDAGRYLC 748

  Fly   567 LASSGLGRSNSSVYLRV--VSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLR 629
            ...:..|..|||..:.|  ......:||..|:          ...::|:|.
Mouse   749 SVCNAKGCVNSSASVAVEGSEDKGSMEIVILI----------GTGVIAVFF-------------- 789

  Fly   630 REKLLKLRIETVHQWTKKVIIY----RPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDP 690
                          |...::|:    ||        :..|::...:.|.             .||
Mouse   790 --------------WVLLLLIFCNMKRP--------AHADIKTGYLSII-------------MDP 819

  Fly   691 AQGFNEYEFPLD----------SNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIV 745
            .      |.||:          |.||.||::|.||.:||.||||:||.|.|.|:.:... .:| |
Mouse   820 G------EVPLEEQCEYLSYDASQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSS-CDT-V 876

  Fly   746 AVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQ-GGPLWVIVEYAPHGNLKDFLK- 808
            ||||:||..|.::..:|:.|::::..||.|:|::||||.|:: .|||.||||:..:|||.:||:
Mouse   877 AVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLRV 941

  Fly   809 -----------------------------QNRPGAPQRRSDS-----DGYLDDKPLISTQH---- 835
                                         :.|||:..|...:     .|.....||:....
Mouse   942 KRDTFNPYAEKSPEQRRRFRAMVEGAKADRRRPGSSDRALFTRFLMGKGSARRAPLVQEAEDLWL 1006

  Fly   836 --LGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDI-QDTEYYRK 897
              |..::|..::||:|||||:||||:||||||||||:|:|:..::||.|||||||| :|.:|.||
Mouse  1007 SPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVRK 1071

  Fly   898 NTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRME 962
            . :.|||:|||||||:.:|.|.:||||||:|||||||.:.|..|||.:...||....|..|.||.
Mouse  1072 G-SARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMR 1135

  Fly   963 KPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQ---------------QASSNPNDAYL 1012
            .|...:..|..:|:.||..:..|||.|::|||....:||               .:.|:..|.::
Mouse  1136 APELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEERMALHSSQSSEEDGFM 1200

  Fly  1013 DLSMPML--------ETPPS---------------------SGDEDDGSD-TETFRE--TSPLRY 1045
            ..|...|        ::|||                     .|.:..||. .:||.|  .:|..|
Mouse  1201 QASTTALHITEADADDSPPSMHCHSLAARYYNCVSFPGRLARGTKTPGSSRMKTFEELPMTPTTY 1265

  Fly  1046 Q 1046
            :
Mouse  1266 K 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	21/92 (23%)
		IGc2	157..215	CDD:197706	16/67 (24%)
		IG	247..336	CDD:214652	25/178 (14%)
		Ig	258..340	CDD:143165	23/132 (17%)
		I-set	394..479	CDD:254352	23/102 (23%)
		IGc2	408..469	CDD:197706	16/68 (24%)
		IG_like	492..583	CDD:214653	24/96 (25%)
		Ig	507..583	CDD:299845	16/78 (21%)
		PKc_like	700..1000	CDD:304357	146/352 (41%)
		TyrKc	712..996	CDD:197581	139/326 (43%)
Flt4	NP_032055.1	IG_like	238..327	CDD:214653	21/92 (23%)
		Ig1_VEGFR	245..329	CDD:143270	20/87 (23%)
		IG_like	341..415	CDD:214653	7/73 (10%)
		Ig	352..418	CDD:299845	8/65 (12%)
		Ig	569..662	CDD:299845	22/104 (21%)
		IG	570..663	CDD:214652	22/104 (21%)
		I-set	678..765	CDD:254352	25/105 (24%)
		IGc2	693..755	CDD:197706	15/74 (20%)
		PKc_like	837..1175	CDD:304357	144/340 (42%)
		Pkinase_Tyr	845..1169	CDD:285015	139/326 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810