DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Flt1

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_034358.2	Gene:	Flt1 / 14254	MGIID:	95558	Length:	1333	Species:	Mus musculus

Alignment Length:	1185	Identity:	326/1185 - (27%)
Similarity:	471/1185 - (39%)	Gaps:	325/1185 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LGCD---YGH--------HR---CYIDVTVENSPRQRHLLSDMDITLQC-------VRPMAKWFY 64
            |.|:   .||        ||   ..:||.: ..|....||....:.|.|       .|....|.|
Mouse   206 LNCEATVNGHLYQTNYLTHRQTNTILDVQI-RPPSPVRLLHGQTLVLNCTATTELNTRVQMSWNY 269

  Fly    65 EDKFQLRATL-----------------LRLERAQSGNSGNYGC---LDSQNRWYNISLVVGHKEP 109
            ..|...||::                 |::...:|.:.|.|.|   ..|..:.:|.|:.|..|
Mouse   270 PGKATKRASIRQRIDRSHSHNNVFHSVLKINNVESRDKGLYTCRVKSGSSFQSFNTSVHVYEK-- 332

  Fly   110 VGNDIASFVKLEDAPALPESDLFFQPLNES----RSLKLLQ-----PLPKTVQRTAGGLFQLNCS 165
                  .|:.::...         ||:.|:    ||.:|..     |.|:.|
Mouse   333 ------GFISVKHRK---------QPVQETTAGRRSYRLSMKVKAFPSPEIV------------- 369

  Fly   166 PMDPDAKGVNISWLHNDTQILGGRGRIKLKRWSLTVGQLQPEDAGSYHCELCVEQDCQRSNPTQL 230
                        ||.:.:.......|..:..:||.:..:..||||.|...|.::|.....|.|..
Mouse   370 ------------WLKDGSPATLKSARYLVHGYSLIIKDVTTEDAGDYTILLGIKQSRLFKNLTAT 422

  Fly   231 EVISRK-----HTVPML--KPGYPRNTSIALGDNVSIECLLEDSALEPKITWL-----HKGNADN 283
            .:::.|     .:|..|  .|.||      ||....:.|.:. ....|.||||     |..:.:.
Mouse   423 LIVNVKPQIYEKSVSSLPSPPLYP------LGSRQVLTCTVY-GIPRPTITWLWHPCHHNHSKER 480

  Fly   284 IDDLLQR-----LREQSQLPVDVTRLITRMD--EPQVLRLGNVLMEDG---GWYICIAENQVGRT 338
            .|...:.     |...|.|...:..:..||.  |.....:..:::.|.   |.|.|.|.|::|
Mouse   481 YDFCTENEESFILDPSSNLGNRIESISQRMTVIEGTNKTVSTLVVADSQTPGIYSCRAFNKIG-- 543

  Fly   339 VAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRL 403
                                   ||...|....|      ||.|.            |...|:::
Mouse   544 -----------------------TVERNIKFYVT------DVPNG------------FHVSLEKM 567

  Fly   404 QHSLSGNTVNLACPV--YGKANITWTKDKKPLNRELGVYVQK---------NWTLRFV--EATSE 455
              ...|..:.|:|.|  :...:|||...:...||.:...:.|         :.||..|  ..:.|
Mouse   568 --PAEGEDLKLSCVVNKFLYRDITWILLRTVNNRTMHHSISKQKMATTQDYSITLNLVIKNVSLE 630

  Fly   456 DSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIVVPQNQT---VKVNGSLVMKCTVYSDLHPTV 517
            |||.|.|:..|.:.........::..|...||.::  ||.:   |.::||..:.|.......|.:
Mouse   631 DSGTYACRARNIYTGEDILRKTEVLVRDSEAPHLL--QNLSDYEVSISGSTTLDCQARGVPAPQI 693

  Fly   518 SWKRVVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLR 582
            :|.:   .|..:.....:.:...|.|       |.:..||.:.||.|.|.|::..|...|:.||.
Mouse   694 TWFK---NNHKIQQEPGIILGPGNST-------LFIERVTEEDEGVYRCRATNQKGAVESAAYLT 748

  Fly   583 V--VSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWT 645
            |  .|....||:..|        |...:.....:||    :|..:|:|:|
Mouse   749 VQGTSDKSNLELITL--------TCTCVAATLFWLL----LTLFIRKLKR--------------- 786

  Fly   646 KKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLD-------- 702
                            ||.:::...:.|.             .||.      |.|||
Mouse   787 ----------------SSSEVKTDYLSII-------------MDPD------EVPLDEQCERLPY 816

  Fly   703 --SNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVRE 765
              |.||..|::|.||..||.||||:||.|.|.|:.:||..  ..|||||:||..|.::..:|:.|
Mouse   817 DASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTC--RTVAVKMLKEGATASEYKALMTE 879

  Fly   766 MEVMKMIGKHINIINLLGCCS-QGGPLWVIVEYAPHGNLKDFLKQNR------------------ 811
            ::::..||.|:|::||||.|: |||||.|||||..:|||.::||..|
Mouse   880 LKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFCLNKDAALHMELKKE 944

  Fly   812 ---PGA---------------------PQRRSDSDGYLD-DKPLISTQHLGEKELTKFAFQIARG 851
               ||.                     |:.||.||...| |...||.|.|..::|..::||:|||
Mouse   945 SLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTMEDLISYSFQVARG 1009

  Fly   852 MEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEK 916
            ||:|:||:||||||||||:|:|:..|:||.||||||||.....|.:..:.|||:|||||||:.:|
Mouse  1010 MEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLPLKWMAPESIFDK 1074

  Fly   917 KYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHF 981
            .|.::|||||||||||||.:.|..|||.:...|:..|.|..|.||..|...:..||.:|..|||.
Mouse  1075 VYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATPEIYQIMLDCWHK 1139

  Fly   982 ESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPM-------LETPPSSGD--EDDGSDTETF 1037
            :...||.||||||....:||.........|:.|:..:       ..||..|.|  :|..:|....
Mouse  1140 DPKERPRFAELVEKLGDLLQANVQQDGKDYIPLNAILTRNSGFTYSTPTFSEDLFKDGFADPHFH 1204

  Fly  1038 RETS-PLRYQYTYKF 1051
            ..:| .:||...:||
Mouse  1205 SGSSDDVRYVNAFKF 1219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	16/82 (20%)
		IGc2	157..215	CDD:197706	10/57 (18%)
		IG	247..336	CDD:214652	23/103 (22%)
		Ig	258..340	CDD:143165	21/96 (22%)
		I-set	394..479	CDD:254352	22/97 (23%)
		IGc2	408..469	CDD:197706	20/73 (27%)
		IG_like	492..583	CDD:214653	23/93 (25%)
		Ig	507..583	CDD:299845	18/75 (24%)
		PKc_like	700..1000	CDD:304357	156/353 (44%)
		TyrKc	712..996	CDD:197581	149/327 (46%)
Flt1	NP_034358.2	IG_like	40..129	CDD:214653
		Ig	46..127	CDD:299845
		IG_like	144..220	CDD:214653	4/13 (31%)
		IG_like	238..329	CDD:214653	19/90 (21%)
		Ig	246..328	CDD:299845	16/81 (20%)
		Ig	354..425	CDD:299845	18/95 (19%)
		IG_like	440..553	CDD:214653	29/144 (20%)
		Ig	452..550	CDD:143165	23/123 (19%)
		IG	570..641	CDD:214652	19/70 (27%)
		IGc2	570..641	CDD:197706	19/70 (27%)
		I-set	662..749	CDD:254352	24/98 (24%)
		IGc2	677..739	CDD:197706	16/71 (23%)
		PKc_like	820..1157	CDD:304357	152/338 (45%)
		Pkinase_Tyr	828..1154	CDD:285015	149/327 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..983		7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810