DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Fgfr4

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_006517162.3	Gene:	Fgfr4 / 14186	MGIID:	95525	Length:	829	Species:	Mus musculus

Alignment Length:	860	Identity:	306/860 - (35%)
Similarity:	427/860 - (49%)	Gaps:	135/860 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   222 CQRSNPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKG----NAD 282
            |:.|.|....::.::..|          .::|||..|.:.|    ...|....|..:|    :|.
Mouse    54 CRASEPCLAPILEQQEQV----------LTVALGQPVRLCC----GRTERGRHWYKEGSRLASAG 104

  Fly   283 NIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLY 347
            .:.....||...|.||                       ||.|.|:|:|...:
Mouse   105 RVRGWRGRLEIASFLP-----------------------EDAGRYLCLARGSM------------ 134

  Fly   348 SPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGP---PVF----RKELKRLQH 405
                 |.|...|..     :..:.|...||:|.:..::.:||.|.|   |.:    |.| |:|..
Mouse   135 -----TVVHNLTLL-----MDDSLTSISNDEDPKTLSSSSSGHVYPQQAPYWTHPQRME-KKLHA 188

  Fly   406 SLSGNTVNLACPVYGK--ANITWTKDKKPL---NRELGVYVQ-KNWTLRFVEATSEDSGLYNCKV 464
            ..:||||...||..|.  ..|.|.||.:..   ||..|:.:: ::|:|........|.|.|.|.|
Mouse   189 VPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLV 253

  Fly   465 CNAWGCIQFDFSVQINDRTRSAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSW-KRVVLKN 526
            .|:.|.|::.:.:.:.:|:...||:.  :|.|.|..|...:.:.|.||||..|.:.| |.||:..
Mouse   254 ENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHVVING 318

  Fly   527 ASL--DGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPP 589
            :|.  ||...|::.......:::..||.||||:.:..|.|||||.:.:|.|..|.:|.|:    |
Mouse   319 SSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVL----P 379

  Fly   590 LEIYALLHAHPLGFTLAAITIVALFLLGS--AFITFMLRRLRREKLLKLRIETVHQWTKKVIIYR 652
            .|......|.|    .|..|.:.|::.||  ..:..:|..:...::::     .|...:.|.|.:
Mouse   380 EEDLTWTTATP----EARYTDIILYVSGSLVLLVLLLLAGVYHRQVIR-----GHYSRQPVTIQK 435

  Fly   653 ----PGGEEGS--GCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQ 711
                |...:.|  ..|||...:.::|..:       ..:.|.....|....:.|||..||.||.:
Mouse   436 LSRFPLARQFSLESRSSGKSSLSLVRGVR-------LSSSGPPLLTGLVNLDLPLDPLWEFPRDR 493

  Fly   712 LSLGSILGEGAFGRVVMAEAEGL-PRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKH 775
            |.||..||||.||:||.|||.|: |..|....| |||||:|:..:|.|:|.||.||||||:||:|
Mouse   494 LVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTST-VAVKMLKDNASDKDLADLVSEMEVMKLIGRH 557

  Fly   776 INIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSD----SDGYLDDKPLISTQHL 836
            .|||||||.|:|.|||:||||.|..|||::||:..||..|....|    |:|.|....|:|.
Mouse   558 KNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSC--- 619

  Fly   837 GEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNG 901
                    |:|:||||:||.||:|||||||||||||::..|||||||||||.:...:||:|.:||
Mouse   620 --------AYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNG 676

  Fly   902 RLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAK 966
            |||:||||||:|.::.|..||||||:|:|||||.|.|..|||.| ..|||:|.|..|.|||:|..
Mouse   677 RLPVKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGI-PVEELFSLLREGHRMERPPN 740

  Fly   967 CSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPSSGDED-- 1029
            |...:|.:||:|||.....||||.:|||:.|.:|...|    :.||||.:......||:||..
Mouse   741 CPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVS----EEYLDLRLTFGPFSPSNGDASST 801

  Fly  1030 -DGSDTETFRETSPL 1043
             ..||:....:..||
Mouse   802 CSSSDSVFSHDPLPL 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	3/9 (33%)
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	20/92 (22%)
		Ig	258..340	CDD:143165	17/85 (20%)
		I-set	394..479	CDD:254352	29/94 (31%)
		IGc2	408..469	CDD:197706	22/66 (33%)
		IG_like	492..583	CDD:214653	34/93 (37%)
		Ig	507..583	CDD:299845	30/78 (38%)
		PKc_like	700..1000	CDD:304357	169/304 (56%)
		TyrKc	712..996	CDD:197581	161/288 (56%)
Fgfr4	XP_006517162.3	IGc2	77..134	CDD:197706	18/83 (22%)
		Ig	184..268	CDD:386229	26/83 (31%)
		Ig3_FGFR-2	291..378	CDD:143266	30/86 (35%)
		PTKc_FGFR4	481..794	CDD:133230	175/329 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1221
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8830
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760