DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Fgfr3

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_001156689.1	Gene:	Fgfr3 / 14184	MGIID:	95524	Length:	802	Species:	Mus musculus

Alignment Length:	852	Identity:	309/852 - (36%)
Similarity:	428/852 - (50%)	Gaps:	118/852 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   227 PTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRL 291
            |.| .|:.|...||..:|......:...||.|.:.|.....|......|...|
Mouse    25 PEQ-RVVRRAAEVPGPEPSQQEQVAFGSGDTVELSCHPPGGAPTGPTVWAKDG------------ 76

  Fly   292 REQSQLPVDVTRLITR---MDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTT 353
                      |.|:..   :..||.|::.|...||.|.|.|  ::::.|.|...:
Mouse    77 ----------TGLVASHRILVGPQRLQVLNASHEDAGVYSC--QHRLTRRVLCHF---------- 119

  Fly   354 TVRTTTTTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFRKELKRLQHSL----SGNTVNL 414
            :||.|..       |::...||.:|..|:        .|.|.:.:. :|:...|    :.|||..
Mouse   120 SVRVTDA-------PSSGDDEDGEDVAED--------TGAPYWTRP-ERMDKKLLAVPAANTVRF 168

  Fly   415 ACPVYGK--ANITWTKDKKPLNREL---GVYVQ-KNWTLRFVEATSEDSGLYNCKVCNAWGCIQF 473
            .||..|.  .:|:|.|:.|....|.   |:.:: :.|:|........|.|.|.|.|.|.:|.|:.
Mouse   169 RCPAAGNPTPSISWLKNGKEFRGEHRIGGIKLRHQQWSLVMESVVPSDRGNYTCVVENKFGSIRQ 233

  Fly   474 DFSVQINDRTRSAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDG----- 531
            .:::.:.:|:...||:.  :|.|||..:...:...|.||||..|.:.|.:.|..|.|..|
Mouse   234 TYTLDVLERSPHRPILQAGLPANQTAILGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGTP 298

  Fly   532 ----LKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEI 592
                |||...:|:.....     |.|.||:....|.|.|.|::.:|.:..:.:|||..|....|
Mouse   299 YVTVLKSWISENVEADAR-----LRLANVSERDGGEYLCRATNFIGVAEKAFWLRVHGPQAAEE- 357

  Fly   593 YALLHAHPLGFTLAAI----TIVALFLLGSAFITFMLRRLRREKLLKLRIETVHQWTKKVIIYRP 653
             .|:.....|...|.:    .:..||:|..|.:  :|.|||......|...|||:.::..:..:.
Mouse   358 -ELMETDEAGSVYAGVLSYGVVFFLFILVVAAV--ILCRLRSPPKKGLGSPTVHKVSRFPLKRQV 419

  Fly   654 GGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPA-QGFNEYEFPLDSNWEIPRQQLSLGSI 717
            ..|..|..:|   ..|::||.:.        :.|..|. ...:|.|.|.|..||:.|.:|:||..
Mouse   420 SLESNSSMNS---NTPLVRIARL--------SSGEGPVLANVSELELPADPKWELSRTRLTLGKP 473

  Fly   718 LGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLL 782
            ||||.||:||||||.|:.:........|||||:|::.||.|::.||.|||:|||||||.||||||
Mouse   474 LGEGCFGQVVMAEAIGIDKDRTAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLL 538

  Fly   783 GCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQ 847
            |.|:|||||:|:||||..|||::||:..||....       |..|...:..:.|..|:|...|:|
Mouse   539 GACTQGGPLYVLVEYAAKGNLREFLRARRPPGMD-------YSFDACRLPEEQLTCKDLVSCAYQ 596

  Fly   848 IARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPES 912
            :|||||||||::|||||||||||||::..||||||||||||:.:.:||:|.||||||:||||||:
Mouse   597 VARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEA 661

  Fly   913 LQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQ 977
            |.::.|..||||||:|||||||.|.|..|||.| ..|||:..|..|.||:|||.|:.::|::||:
Mouse   662 LFDRVYTHQSDVWSFGVLLWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPASCTHDLYMIMRE 725

  Fly   978 CWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPM-------LETPPSSGDEDDGSDTE 1035
            |||.....||||.:|||..|.||...|:   |.|||||:|.       .:||.||...||...|.
Mouse   726 CWHAVPSQRPTFKQLVEDLDRILTVTST---DEYLDLSVPFEQYSPGGQDTPSSSSSGDDSVFTH 787

  Fly  1036 TFRETSP 1042
            ......|
Mouse   788 DLLPPGP 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	2/4 (50%)
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	18/91 (20%)
		Ig	258..340	CDD:143165	17/84 (20%)
		I-set	394..479	CDD:254352	25/94 (27%)
		IGc2	408..469	CDD:197706	20/66 (30%)
		IG_like	492..583	CDD:214653	29/99 (29%)
		Ig	507..583	CDD:299845	25/84 (30%)
		PKc_like	700..1000	CDD:304357	169/299 (57%)
		TyrKc	712..996	CDD:197581	163/283 (58%)
Fgfr3	NP_001156689.1	IGc2	51..110	CDD:197706	18/82 (22%)
		IG	52..108	CDD:214652	18/79 (23%)
		Ig2_FGFR	155..239	CDD:143265	23/83 (28%)
		IG_like	254..349	CDD:214653	29/99 (29%)
		Ig3_FGFR	262..350	CDD:143175	26/92 (28%)
		PTKc_FGFR3	455..788	CDD:173652	186/343 (54%)
		Pkinase_Tyr	468..744	CDD:285015	163/283 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1221
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8830
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.890