DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Fgfr2

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_034337.2	Gene:	Fgfr2 / 14183	MGIID:	95523	Length:	840	Species:	Mus musculus

Alignment Length:	899	Identity:	322/899 - (35%)
Similarity:	457/899 - (50%)	Gaps:	122/899 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   176 ISWLHNDTQILGGRGRIKLKRWSLTVGQ---LQPEDAGSYHCELCVEQDCQRSNPTQLEVISRKH 237
            :||......:|.....:.|.|.|.::.:   |:||:.                 ||:.::
Mouse    21 VSWGRFICLVLVTMATLSLARPSFSLVEDTTLEPEEP-----------------PTKYQI----- 63

  Fly   238 TVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITW----LHKGNADNIDDLLQRLREQSQLP 298
                   ..|....:|.|:::.::|:|:|:|:   |:|    :|.|                  |
Mouse    64 -------SQPEAYVVAPGESLELQCMLKDAAV---ISWTKDGVHLG------------------P 100

  Fly   299 VDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTV 363
            .:.|.||     .:.|::......|.|.|.|.|    .|||         .|:|.......|..:
Mouse   101 NNRTVLI-----GEYLQIKGATPRDSGLYACTA----ARTV---------DSETWYFMVNVTDAI 147

  Fly   364 ASPIPTASTGEDNDDDVENPAAEASGGVGPPVF---RKELKRLQHSLSGNTVNLACPVYGKANIT 425
            :|     ...||:.|..|:..:|.......|.:   .|..|||....:.|||...||..|....|
Mouse   148 SS-----GDDEDDTDSSEDVVSENRSNQRAPYWTNTEKMEKRLHAVPAANTVKFRCPAGGNPTPT 207

  Fly   426 --WTKDKKPLNRE--LGVYVQKN--WTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTR 484
              |.|:.|...:|  :|.|..:|  |:|........|.|.|.|.|.|.:|.|...:.:.:.:|:.
Mouse   208 MRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGNYTCLVENEYGSINHTYHLDVVERSP 272

  Fly   485 SAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASLDG------LKSVEIQNLN 541
            ..||:.  :|.|.:..|.|.:...|.||||..|.:.|.:.|.||.|..|      ||.::...:|
Mouse   273 HRPILQAGLPANASTVVGGDVEFVCKVYSDAQPHIQWIKHVEKNGSKYGPDGLPYLKVLKAAGVN 337

  Fly   542 FTVTNDSVVLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLA 606
             |...:..||.:|||||:..|.|||||.:.:|.|..|.:|.|: |.|..|  ..:.|.| .:...
Mouse   338 -TTDKEIEVLYIRNVTFEDAGEYTCLAGNSIGISFHSAWLTVL-PAPVRE--KEITASP-DYLEI 397

  Fly   607 AITIVALFLLGSAFITFMLRRLR--REKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMP 669
            ||..:.:||:....:|.:..|::  .:|........||:.||::.:.|.........||.:...|
Mouse   398 AIYCIGVFLIACMVVTVIFCRMKTTTKKPDFSSQPAVHKLTKRIPLRRQVTVSAESSSSMNSNTP 462

  Fly   670 VIRIEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGL 734
            ::||     |...:.|..|....|.:|||.|.|..||.||.:|:||..||||.||:||||||.|:
Mouse   463 LVRI-----TTRLSSTADTPMLAGVSEYELPEDPKWEFPRDKLTLGKPLGEGCFGQVVMAEAVGI 522

  Fly   735 PRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAP 799
            .:........|||||:|::.|:.|::.||.|||:|||||||.|||||||.|:|.|||:||||||.
Mouse   523 DKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYAS 587

  Fly   800 HGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRD 864
            .|||:::|:..||...:       |..|...:..:.:..|:|....:|:|||||||||::|||||
Mouse   588 KGNLREYLRARRPPGME-------YSYDINRVPEEQMTFKDLVSCTYQLARGMEYLASQKCIHRD 645

  Fly   865 LAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGV 929
            ||||||||::..|||||||||||||.:.:||:|.||||||:||||||:|.::.|..||||||:||
Mouse   646 LAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGV 710

  Fly   930 LLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVE 994
            |:|||.|.|..|||.| ..|||:..|..|.||:||..|:..:|::||.|||.....||||.:|||
Mouse   711 LMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPTNCTNELYMMMRDCWHAVPSQRPTFKQLVE 774

  Fly   995 SFDGILQQASSNPNDAYLDLSMPMLETPPSSGD--EDDGSDTETFRETSPLRYQ 1046
            ..|.||   :...|:.||||:.|:.:..||..|  ....|..::.....|:.|:
Mouse   775 DLDRIL---TLTTNEEYLDLTQPLEQYSPSYPDTRSSCSSGDDSVFSPDPMPYE 825

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	11/58 (19%)
		IGc2	157..215	CDD:197706	9/41 (22%)
		IG	247..336	CDD:214652	21/92 (23%)
		Ig	258..340	CDD:143165	20/85 (24%)
		I-set	394..479	CDD:254352	29/93 (31%)
		IGc2	408..469	CDD:197706	22/66 (33%)
		IG_like	492..583	CDD:214653	37/96 (39%)
		Ig	507..583	CDD:299845	33/81 (41%)
		PKc_like	700..1000	CDD:304357	165/299 (55%)
		TyrKc	712..996	CDD:197581	158/283 (56%)
Fgfr2	NP_034337.2	Ig	66..143	CDD:325142	26/115 (23%)
		Ig2_FGFR	183..267	CDD:143265	27/83 (33%)
		Ig3_FGFR-2	290..379	CDD:143266	34/89 (38%)
		PTKc_FGFR2	475..787	CDD:270679	173/322 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1221
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H22566
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8830
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760