DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and Fgfr1

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_034336.2	Gene:	Fgfr1 / 14182	MGIID:	95522	Length:	822	Species:	Mus musculus

Alignment Length:	827	Identity:	304/827 - (36%)
Similarity:	424/827 - (51%)	Gaps:	111/827 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 GDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQSQLPVDVTRLITRMDEPQVLRLGNV 319
            ||.:.:.|.|.|..  ..|.||..|         .:|.|.::         ||:...:| .:.:.
Mouse    48 GDLLQLRCRLRDDV--QSINWLRDG---------VQLVESNR---------TRITGEEV-EVRDS 91

  Fly   320 LMEDGGWYICIAENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDNDDDVENPA 384
            :..|.|.|.|:..:..|             ||||..    :..|:..:|::   ||:|||.::.:
Mouse    92 IPADSGLYACVTSSPSG-------------SDTTYF----SVNVSDALPSS---EDDDDDDDSSS 136

  Fly   385 AEASGGVGPPVFR----------KELKRLQHSLSGNTVNLACPVYGKANIT--WTKDKKPL--NR 435
            .|.......|..|          |..|:|....:..||...||..|..|.|  |.|:.|..  :.
Mouse   137 EEKETDNTKPNRRPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDH 201

  Fly   436 ELGVYVQK--NWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIV--VPQNQT 496
            .:|.|..:  .|::........|.|.|.|.|.|.:|.|...:.:.:.:|:...||:.  :|.|:|
Mouse   202 RIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKT 266

  Fly   497 VKVNGSLVMKCTVYSDLHPTVSWKRVVLKNASL---DGLKSVEI---QNLNFTVTNDSVVLTLRN 555
            |.:..::...|.||||..|.:.|.:.:..|.|.   |.|..|:|   ..:| |...:..||.|||
Mouse   267 VALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVN-TTDKEMEVLHLRN 330

  Fly   556 VTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAF 620
            |:|:..|.|||||.:.:|.|:.|.:|.|:.         .|...|...|......:.::..|:..
Mouse   331 VSFEDAGEYTCLAGNSIGLSHHSAWLTVLE---------ALEERPAVMTSPLYLEIIIYCTGAFL 386

  Fly   621 ITFMLRRLRREKLLKLRIET----------VHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEK 675
            |:.||..:   .:.|::..|          ||:..|.:.:.|.  ...|..||..:...|:.:..
Mouse   387 ISCMLGSV---IIYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQ--VTVSADSSASMNSGVLLVRP 446

  Fly   676 QRTTVSTTGTGGTDPAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQL 740
            .|.:.|     ||....|.:|||.|.|..||:||.:|.||..||||.||:||:|||.||.:....
Mouse   447 SRLSSS-----GTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPN 506

  Fly   741 AETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKD 805
            ..|.|||||:|.:.|:.|::.|:.|||:|||||||.|||||||.|:|.|||:||||||..|||::
Mouse   507 RVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLRE 571

  Fly   806 FLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNV 870
            :|:..||...:       |..:......:.|..|:|...|:|:|||||||||::|||||||||||
Mouse   572 YLQARRPPGLE-------YCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNV 629

  Fly   871 LVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIM 935
            ||::..|||||||||||||...:||:|.||||||:||||||:|.::.|..||||||:|||||||.
Mouse   630 LVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIF 694

  Fly   936 TYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGIL 1000
            |.|..|||.: ..|||:..|..|.||:||:.|:..:|::||.|||.....||||.:|||..|.|:
Mouse   695 TLGGSPYPGV-PVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV 758

  Fly  1001 QQASSNPNDAYLDLSMPMLETPPSSGDE-----DDGSDTETFRETSP 1042
            ...|   |..|||||:|:.:..||..|.     ..|.|:....|..|
Mouse   759 ALTS---NQEYLDLSIPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLP 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	18/80 (23%)
		Ig	258..340	CDD:143165	17/81 (21%)
		I-set	394..479	CDD:254352	26/100 (26%)
		IGc2	408..469	CDD:197706	19/66 (29%)
		IG_like	492..583	CDD:214653	36/96 (38%)
		Ig	507..583	CDD:299845	32/81 (40%)
		PKc_like	700..1000	CDD:304357	166/299 (56%)
		TyrKc	712..996	CDD:197581	159/283 (56%)
Fgfr1	NP_034336.2	Ig1_FGFR	40..118	CDD:143174	23/107 (21%)
		IG_like	41..118	CDD:214653	23/107 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..162		10/44 (23%)
		I-set	160..247	CDD:254352	24/86 (28%)
		Heparin-binding	160..177		5/16 (31%)
		Ig2_FGFR	163..247	CDD:143265	23/83 (28%)
		IG_like	262..358	CDD:214653	36/96 (38%)
		Ig3_FGFR	270..359	CDD:143175	32/89 (36%)
		PTKc_FGFR1	464..765	CDD:270678	170/311 (55%)
		Pkinase_Tyr	478..754	CDD:285015	159/283 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	782..822		5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1221
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	477	1.000	Inparanoid score	I1461
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm8830
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6544
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.760