DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and fgfr2

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	XP_012821350.1	Gene:	fgfr2 / 100124910	XenbaseID:	XB-GENE-1018296	Length:	834	Species:	Xenopus tropicalis

Alignment Length:	903	Identity:	320/903 - (35%)
Similarity:	451/903 - (49%)	Gaps:	136/903 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   173 GVNISWLHNDTQILGGRGRIKLKRWSLTVGQL-------QPEDAGSYHCELCVEQDCQRSNPTQL 230
            |:::.|.....   ||.|........:.:|.|       :|    |||  :..:...:...|...
Frog     2 GMSLVWRSGKA---GGGGHADRMLVLVLLGLLLVSRTIARP----SYH--MAEDTTSEPEEPPAK 57

  Fly   231 EVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITWLHKGNADNIDDLLQRLREQS 295
            ..||:....|:| ||.|          :.:.|.|.|.   |.:||    |.|.           :
Frog    58 YQISKADVFPVL-PGEP----------LDLRCPLADG---PPVTW----NKDG-----------A 93

  Fly   296 QLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYIC-IAENQVGRTVAASYVDLYSPSDTTTVRTTT 359
            :|.|:...||.|    ..|::......|.|.|.| :.:|                |....|..|
Frog    94 KLEVNNRTLIVR----NYLQIKETTPRDSGLYSCSVLKN----------------SHFFHVNVT- 137

  Fly   360 TTTVASPIPTASTGEDNDD-DVENPAAEASGGVGPPVF---RKELKRLQHSLSGNTVNLACPVYG 420
                    ..:|:|:|.|| |........:..:..|.:   .|..|:|....:.|||.|.||..|
Frog   138 --------EASSSGDDEDDNDGSEDFTNDNNNIRAPYWTNTEKMEKKLHAVPAANTVKLRCPAGG 194

  Fly   421 K--ANITWTKDKKPLNRE--LGVYVQKN--WTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQI 479
            .  ..:.|.|:.|...:|  :|.|..:|  |:|........|.|:|.|.|.|..|.|...:.:.:
Frog   195 NPTPRMRWLKNGKEFKQEHRIGGYKVRNQHWSLIMESVVPSDKGIYTCIVENEHGSINHTYHLDV 259

  Fly   480 NDRTRSAPIIV--VPQNQTVKVNGSLVMKCTVYSDLHPTVSWKRVVLKNAS---LDGLKSVEI-Q 538
            .:|:...||:.  :|.|.|..|.|.....|.||||..|.:.|.|.:.||.|   :|||..::: :
Frog   260 IERSSHRPILQAGLPANTTAMVGGDAEFVCKVYSDAQPHIRWVRYIEKNGSRFGVDGLPYIKVLK 324

  Fly   539 NLNFTVTNDSV-VLTLRNVTFDQEGWYTCLASSGLGRSNSSVYLRV----VSPLP--PLEIYALL 596
            .....||::.: ||.:|||:|:..|.|||:|.:.:|.|..|.:|.|    |||..  |:..|..:
Frog   325 AAGVNVTDEEIEVLYVRNVSFEDAGEYTCIAGNSIGISQHSAWLTVHPATVSPGEDNPVPYYMEI 389

  Fly   597 HAHPLGFTLAAITIVALFLLGSAFITFMLRRLRR--EKLLKLRIETVHQWTKKVIIYRPGGEEGS 659
            ..:..|          :|::....:..::.|:|:  :|........||:.||::.::|.......
Frog   390 GIYSAG----------IFIIFCMVVICVVCRMRQGAKKKKNFTGPPVHKLTKRIPLHRQVTVSAD 444

  Fly   660 GCSSGDLQMPVIRIEKQRTTVSTTGTGGTD--PAQGFNEYEFPLDSNWEIPRQQLSLGSILGEGA 722
            ..||.:...|::||       :|.....||  |....:|||.|.|..||..|.:|:||..||||.
Frog   445 SSSSMNSTTPLVRI-------TTRLLSSTDAMPLPNVSEYELPHDPLWEFSRDKLTLGKPLGEGC 502

  Fly   723 FGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCSQ 787
            ||:||||||.|:.:........|||||:|::.|:.|:|.||.|||:||:||||.|||||||.|:|
Frog   503 FGQVVMAEALGIDKDRPKESVTVAVKMLKDDATEKDLADLVSEMEMMKIIGKHKNIINLLGACTQ 567

  Fly   788 GGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQHLGEKELTKFAFQIARGM 852
            ||.|:||||||..|||:.:|:..||...:       |..|...:..:.:..|:|....:||||||
Frog   568 GGTLYVIVEYAAKGNLRQYLRARRPLEME-------YSFDVTRVPDEQMTFKDLVSCTYQIARGM 625

  Fly   853 EYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNTNGRLPIKWMAPESLQEKK 917
            |||||::|||||||||||||::..||||||||||||:.:.:||:|.||||||:||||||:|.::.
Frog   626 EYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDVNNIDYYKKTTNGRLPVKWMAPEALFDRV 690

  Fly   918 YDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKPAKCSLNIYVVMRQCWHFE 982
            |..||||||:|||:|||.|.|..|||.| ..|||:..|..|.||:||..|:..:|::||.|||..
Frog   691 YTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELFKLLKEGHRMDKPGNCTNELYMMMRDCWHAI 754

  Fly   983 SCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETPPS------SGDEDDGSDT 1034
            ...||||.:|||..|.||   :...|:.|||||.|:.:..||      |.....|.|:
Frog   755 PSHRPTFKQLVEDLDRIL---TLTTNEEYLDLSAPLEQYSPSFPDSSCSASSSSGDDS 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	12/65 (18%)
		IGc2	157..215	CDD:197706	11/48 (23%)
		IG	247..336	CDD:214652	20/89 (22%)
		Ig	258..340	CDD:143165	19/82 (23%)
		I-set	394..479	CDD:254352	28/93 (30%)
		IGc2	408..469	CDD:197706	22/66 (33%)
		IG_like	492..583	CDD:214653	36/95 (38%)
		Ig	507..583	CDD:299845	31/80 (39%)
		PKc_like	700..1000	CDD:304357	164/299 (55%)
		TyrKc	712..996	CDD:197581	158/283 (56%)
fgfr2	XP_012821350.1	Ig	64..136	CDD:299845	26/120 (22%)
		IG_like	68..137	CDD:214653	25/117 (21%)
		Ig2_FGFR	175..259	CDD:143265	26/83 (31%)
		IG	185..259	CDD:214652	23/73 (32%)
		IG_like	274..370	CDD:214653	36/95 (38%)
		Ig3_FGFR-2	282..371	CDD:143266	32/88 (36%)
		PTKc_FGFR2	467..779	CDD:270679	172/322 (53%)
		Pkinase_Tyr	492..768	CDD:285015	158/283 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	325	1.000	Domainoid score	I1193
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H22566
Inparanoid	1	1.050	462	1.000	Inparanoid score	I1519
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm9491
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060