DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment btl and fgfr4

DIOPT Version :9

Sequence 1:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_571505.1	Gene:	fgfr4 / 100000160	ZFINID:	ZDB-GENE-980526-488	Length:	922	Species:	Danio rerio

Alignment Length:	947	Identity:	314/947 - (33%)
Similarity:	463/947 - (48%)	Gaps:	164/947 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 LC-VEQDCQRS----NPTQLEVISRKHTVPMLKPGYPRNTSIALGDNVSIECLLEDSALEPKITW 275
            :| :|..|.||    .|...::...:|   :|.||||.|.::.:|.:|.:.|.|...| ..::.|
Zfish    11 ICFMELVCSRSITSGEPRAKDIRVSRH---ILTPGYPENATVLVGGHVKLVCKLHQPA-STRLQW 71

  Fly   276 LHKGNADNIDDLLQRL-REQSQLPVDVTRLITRMDEPQVLRLGNVLMEDGGWYICIAENQVGRTV 339
            ..|.:        .|| .:.|.:...:|.|:..:.:..:..|.|:.:||.|.|:|.|||..|:..
Zfish    72 FKKDS--------NRLGPDGSPVLTALTPLLENLSKVNIFPLVNISLEDAGEYVCKAENSAGQAT 128

  Fly   340 AASYVDLYS---------PS--------DTTTVRTTT---------------------------- 359
            .:::|::.|         ||        |...:|..|
Zfish   129 RSAWVEVLSEVSEEPTEEPSEHLLLELGDVLKLRCDTNRPGAVQWFKSGVRVQHNARIQIRAAVM 193

  Fly   360 ---------------------------TTTVASPIPTASTGEDNDDDVENPAAEASGGVGPPVFR 397
                                       |.|||..:     |..:|||.:|...:    :||....
Zfish   194 EIADVTYEDSGVYVCMLRGTKEALRNFTITVADAV-----GSGDDDDEDNGLDD----IGPETEN 249

  Fly   398 KEL-----------KRLQHSL----SGNTVNLACPVYGK--ANITWTKDKKPLNREL---GVYVQ 442
            .::           :|::..|    :||||...||..|.  ..|.|.|:.:....|.   |:.::
Zfish   250 DQVYISRAPYWTHTQRMEKKLYAVPAGNTVKFRCPATGSPLPTIRWLKNGREFRGEHRIGGIKLR 314

  Fly   443 -KNWTLRFVEATSEDSGLYNCKVCNAWGCIQFDFSVQINDRTRSAPIIV--VPQNQTVKVNGSLV 504
             ::|:|........|.|.|:|.|.|.:|.|...:.:.:.:|:...||:.  :|:|.|..|.|...
Zfish   315 HQHWSLVMESVVPSDRGNYSCVVENKYGSIAHTYLLDVLERSPHRPILQAGLPKNTTAIVGGDAQ 379

  Fly   505 MKCTVYSDLHPTVSWKRVVLKNASL---DGLKSVEIQNLNFTVTNDSVVLTLRNVTFDQEGWYTC 566
            ..|.||||..|.:.|.:.:..|.|.   ||:..|:|........::..||.|.|::.:..|.|:|
Zfish   380 FLCKVYSDAQPHIQWLKHIEMNGSRYGPDGIPYVKIVKTGSLNMSEVEVLYLTNISMEDAGEYSC 444

  Fly   567 LASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSAFITFMLRRLR-- 629
            ||.:.:|.|:.|.:|.|:|.....:...|:.|......:.|...:||.:   |.:..:|.|::
Zfish   445 LAGNSIGFSHQSAWLTVLSEEDVAKEVDLMEAKYTDIIIYASGFLALVM---AIVIVVLCRMQVH 506

  Fly   630 --REKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTGTGGTDPAQ 692
              ||....|.::.:    .|..:.|....|.:  |||.....::|:.:..::.|..       ..
Zfish   507 PSREPFDTLPVQKL----SKFPLRRQYSVESN--SSGKSSASLMRVARLSSSCSPM-------LA 558

  Fly   693 GFNEYEFPLDSNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDT 757
            |..|:|.|.|.:||.||:.|:||..||||.||:||.|||.|:.:..|.....|||||:|::.||.
Zfish   559 GVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEAYGINKENQDHMATVAVKMLKDDATDK 623

  Fly   758 DMASLVREMEVMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSD 822
            |:|.|:.|||:||::.||.|||||||.|:|.|||:|:||||..|:|:::|:..||....
Zfish   624 DLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRPPGMD------ 682

  Fly   823 GYLDDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLAR 887
             |..|...:..:.|..|:|...|:|:|||||||||:||||||||||||||::..|||||||||||
Zfish   683 -YTFDVTKVPEEQLTFKDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGLAR 746

  Fly   888 DIQDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELY 952
            .:...:||:|.||||:|:||||||:|.::.|..||||||:|||:|||.|.|..|||.| ..|||:
Zfish   747 GVHQIDYYKKTTNGRMPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGI-PVEELF 810

  Fly   953 SYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMP 1017
            ..|..|.||:||:.|:..:|:.||:|||.....||||.:|||..|.:|...|    |.|||||.|
Zfish   811 KLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEELDRVLVSIS----DEYLDLSTP 871

  Fly  1018 MLETPPSSGD-------EDDGSDTETFRETSPLRYQY 1047
            ..:..||..|       ::|...|.....|.|....|
Zfish   872 FEQYSPSCEDTSSSCSSDNDSVFTHDALSTEPCLLGY 908

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
btl	NP_001014583.1	IG_like	149..232	CDD:214653	6/20 (30%)
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652	24/89 (27%)
		Ig	258..340	CDD:143165	22/82 (27%)
		I-set	394..479	CDD:254352	24/105 (23%)
		IGc2	408..469	CDD:197706	20/66 (30%)
		IG_like	492..583	CDD:214653	31/93 (33%)
		Ig	507..583	CDD:299845	26/78 (33%)
		PKc_like	700..1000	CDD:304357	161/299 (54%)
		TyrKc	712..996	CDD:197581	154/283 (54%)
fgfr4	NP_571505.1	IG_like	44..135	CDD:214653	26/99 (26%)
		Ig	52..136	CDD:299845	24/92 (26%)
		IG_like	150..224	CDD:214653	4/73 (5%)
		IGc2	156..212	CDD:197706	3/55 (5%)
		Ig2_FGFR	268..352	CDD:143265	23/83 (28%)
		IG_like	273..352	CDD:214653	22/78 (28%)
		IG_like	367..461	CDD:214653	31/93 (33%)
		Ig3_FGFR-2	375..462	CDD:143266	27/86 (31%)
		PTKc_FGFR4	565..877	CDD:133230	170/323 (53%)
		Pkinase_Tyr	578..854	CDD:285015	154/283 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	321	1.000	Domainoid score	I1203
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1538
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D119660at33208
OrthoFinder	1	1.000	-	-		FOG0000923
OrthoInspector	1	1.000	-	-		mtm6455
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X537
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.730